MiRNAs in Lung Adenocarcinoma: Role, Diagnosis, Prognosis, and Therapy

Lung cancer has emerged as a significant public health challenge and remains the leading cause of cancer-related mortality worldwide. Among various types of lung malignancies, lung adenocarcinoma (LUAD) stands as the most prevalent form. MicroRNAs (miRNAs) play a crucial role in gene regulation, and their involvement in cancer has been extensively explored. While several reviews have been published on miRNAs and lung cancer, there remains a gap in the review regarding miRNAs specifically in LUAD. In this review, we not only highlight the potential diagnostic, prognostic, and therapeutic implications of miRNAs in LUAD, but also present an inclusive overview of the extensive research conducted on miRNAs in this particular context.

Automated summary

Lung cancer, particularly lung adenocarcinoma (LUAD), is a major public health challenge and the leading cause of cancer-related deaths worldwide. MicroRNAs (miRNAs) have crucial roles in gene regulation and their involvement in cancer is extensively studied. However, there is a gap in the literature regarding the specific role of miRNAs in LUAD. This review provides an inclusive overview of the research conducted on miRNAs in the context of LUAD, highlighting their potential diagnostic, prognostic, and therapeutic implications.