相关参考文献
注意：仅列出部分参考文献，下载原文获取全部文献信息。
Review
Biochemistry & Molecular Biology
Sylvain Loric et al.
Summary: Breast cancer is the most frequent cancer worldwide, with higher incidence in females. Despite declining mortality rates, there are significant differences in outcomes between early and metastatic breast cancer. Treatment choice relies on precise characterization, but recurrence and metastasis may still occur. Tumor cells and their microenvironment, particularly extracellular vesicles like exosomes, play a crucial role in tumor escape. This review focuses on the role of extracellular vesicles in breast cancer tissues and their potential use for diagnosis, follow-up, prognosis, and as targets for therapy or drug delivery.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Martha Paluschinski et al.
Summary: Liver diseases require reliable biomarkers for early detection, prognosis, and therapeutic monitoring. Extracellular vesicles (EVs) have emerged as promising candidates for liver disease biomarkers due to their unique cargo composition, stability, and accessibility in various biological fluids. This study presents an optimized workflow for identifying EVs-based biomarkers in liver disease, including EVs isolation, characterization, cargo analysis, and biomarker validation. It was found that specific microRNAs and cytokines differed in EVs isolated from patients with different liver diseases. Implementation of this workflow can enhance liver disease diagnosis, prognosis, and personalized treatment strategies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Bojana Milutinovic et al.
Summary: The neurotoxic side effects of chemotherapy, such as deficits in attention, memory, and executive functioning, currently lack FDA-approved therapies. This study demonstrated that intranasal treatment with small extracellular vesicles derived from mesenchymal stem cells (MSCs) reversed the cognitive impairments and brain damage induced by cisplatin in mice. The intranasally administered sEVs entered the brain within 30 minutes and restored the abnormalities in mitochondrial morphology, loss of white matter, and synaptic integrity in the hippocampus. Transcriptomic analysis revealed potential pathways involved in the recovery process. The findings suggest that intranasal sEV treatment could be a novel therapeutic approach for chemobrain.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Severin Gylstorff et al.
Summary: This study investigates the immune profiles and origins of extracellular vesicles (EVs) in patients with inoperable hepatocellular carcinoma (HCC) before and after radioembolization (RE)/selective internal radiotherapy (SIRT) treatment. The presence of certain immune markers in EVs positively correlated with therapy response and survival. Conversely, other markers showed a negative correlation with survival. Plasma EVs from HCC patients exhibited immunological, cancer, and coagulation markers, including potential biomarkers for SIRT therapy monitoring.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Phillip Munson et al.
Summary: This review summarizes the role of exosomes in the development of malignant mesothelioma (MM), and discusses their potential in detection and treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Rebekka Van Hoof et al.
Summary: Extracellular vesicles (EVs) containing short genomic DNA can serve as templates for molecular diagnostics, and their isolation can be enhanced by using size exclusion chromatography (SEC). The EGFR T790M mutation can be detected in the lumen of sEVs using digital PCR. SEC-based sEV separation can increase the mutant allele frequencies in spiked human plasma samples, potentially due to co-purification of circulating tumor DNA.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Rune Matthiesen et al.
Summary: This study characterized and evaluated the proteome of plasma extracellular vesicles in DLBCL patients, and found that these proteins are closely associated with the status of DLBCL and may serve as prognostic markers for patient survival.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
