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Lipid Nanoparticles: An Effective Tool to Improve the Bioavailability of Nutraceuticals

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2023)

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Article Pharmacology & Pharmacy

SV-AUC as a stability-indicating method for the characterization of mRNA-LNPs

Anian Thaller et al.

Summary: The study found that sedimentation velocity analytical ultracentrifugation (SV-AUC) can be used as a highly valuable quantitative stability-indicating method to detect structural changes of mRNA-LNP vaccines upon stress factors. SV-AUC can observe changes in particle density that cannot be detected by dynamic light scattering (DLS) analysis.

EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS (2023)

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Article Pharmacology & Pharmacy

Enhanced anticancer activity of encapsulated geraniol into biocompatible lipid nanoparticles against A549 human lung cancer cells

Boris Rodenak-Kladniew et al.

Summary: Geraniol (GOH), a monoterpene alcohol found in essential oils, was encapsulated into nanostructured lipid carriers (NLC) to improve its anticancer activity. The NLC/GOH exhibited high stability and low dispersity, and showed increased release of GOH at acidic pH. The NLC/GOH were safe, absorbed serum proteins, and preferentially interacted with human serum albumin. A time-dependent cellular uptake of NLC/GOH was observed in A549 cells, leading to increased cytotoxicity, mitochondrial membrane depolarization, and cell death. NLC/GOH showed highly cytotoxic concentrations against A549 cells but was non-toxic to normal lung fibroblasts. Additionally, GOH nanoencapsulation into NLC potentiated the inhibition of A549 cell migration.

JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY (2023)

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Article Nanoscience & Nanotechnology

Incorporation of glycyrrhizic acid and polyene phosphatidylcholine in lipid nanoparticles ameliorates acute liver injury via delivering p65 siRNA

Qiming Yin et al.

Summary: In this study, a new strategy of incorporating glycyrrhizic acid (GA) and polyene phosphatidylcholine (PPC) into lipid nanoparticles (GA/PPC-modified LNPs) was developed, which showed enhanced cellular uptake, improved gene-silencing efficiency, reduced cytotoxicity, and increased siRNA stability. GA/PPC-modified LNPs targeting NF-kappa B attenuated acute liver injury and facilitated intracellular delivery of antisense oligonucleotides (ASOs) and mRNA inhibiting viral infection. These findings suggest that GA/PPC-modified LNPs could serve as a promising nucleic acid delivery system.

NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE (2023)

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Article Pharmacology & Pharmacy

Development and Optimisation of Inhalable EGCG Nano-Liposomes as a Potential Treatment for Pulmonary Arterial Hypertension by Implementation of the Design of Experiments Approach

Fatma Haddad et al.

Summary: Epigallocatechin gallate (EGCG), the main ingredient in green tea, shows potential as a treatment for pulmonary arterial hypertension (PAH). However, EGCG has limitations such as stability issues and low bioavailability. This study aimed to develop an inhalable nano-liposome formulation of EGCG to overcome these drawbacks. The optimized formulation exhibited desirable aerodynamic properties and inhibited TGF-beta signaling, indicating its potential as a treatment for PAH.

PHARMACEUTICS (2023)

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Article Pharmacology & Pharmacy

Honokiol-Loaded Nanoemulsion for Glioblastoma Treatment: Statistical Optimization, Physicochemical Characterization, and an In Vitro Toxicity Assay

Aleksandra Gostynska et al.

Summary: In this study, honokiol-loaded nanoemulsion for glioblastoma therapy was developed, optimized, and characterized. The nanoemulsion showed good stability and satisfactory toxicity effect against glioblastoma cell lines.

PHARMACEUTICS (2023)

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Article Biophysics

Development, characterization and in vitro cytotoxicity of kaempferol-loaded nanostructured lipid carriers in glioblastoma multiforme cells

Luisa Ribeiro Nicoleti et al.

Summary: Glioblastoma multiforme is a common and aggressive brain cancer, and current treatments face challenges. Kaempferol, a flavonoid, shows anti-tumor activity but has limited bioavailability. The use of nanostructured lipid carriers (NLC) can improve the delivery of lipophilic drugs, enhancing their therapeutic efficacy.

COLLOIDS AND SURFACES B-BIOINTERFACES (2023)

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Article Biophysics

Nanoemulsion containing Yellow Monascus pigment : Fabrication, characterization, storage stability, and lipase hydrolytic activity in vitro digestion

Kexin Li et al.

Summary: In this study, a novel corn oil-based nanoemulsion encapsulated with Yellow Monascus Pigment crude extract (CO-YMPN) was successfully prepared. The optimized fabrication conditions were a emulsifier ratio of 5:3 (Tween 60 to Tween 80) and a Yellow Monascus Pigment crude extract (YMPCE) concentration of 20.00% wt%. CO-YMPN showed excellent DPPH radical scavenging capability and improved lipase hydrolysis capacity. It also exhibited excellent storage stability and water solubility in the final water system.

COLLOIDS AND SURFACES B-BIOINTERFACES (2023)

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Article Biophysics

Caffeic acid loaded into engineered lipid nanoparticles for Alzheimer's disease therapy

Stephanie Andrade et al.

Summary: Alzheimer's disease (AD) is an incurable neurological illness and the leading cause of dementia, characterized by amyloid beta (Aβ) fibril deposits. Caffeic acid (CA) has potential value for AD therapy due to its antiamyloidogenic, anti-inflammatory, and antioxidant properties. Liposomes loading CA were produced and Tf was conjugated to the liposomes' surface to direct the nanoparticles (NPs) to the blood-brain barrier. The optimized Tf-modified NPs exhibited suitable physical properties and encapsulation efficiency, and showed sustained release of CA for 8 days. The drug delivery system (DDS) can prevent Aβ aggregation and fibril formation, and disaggregate mature fibrils, indicating its potential for preventing and treating AD.

COLLOIDS AND SURFACES B-BIOINTERFACES (2023)

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Article Engineering, Biomedical

Targeted delivery and anticancer effects of Chrysin-loaded chitosan-folic acid coated solid lipid nanoparticles in pancreatic malignant cells

Amin Farhadi et al.

Summary: The aim of this study was to enhance the treatment effectiveness by loading Chrysin (CHY) on solid lipid nanoparticles (SLNs) and decorating them with folate-bound chitosan. The synthesized CHY-SCF-NPs showed increased size, change in surface charge, and demonstrated potent anti-cancer properties, making them a promising candidate for pancreatic cancer treatment.

JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION (2023)

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Review Biochemistry & Molecular Biology

Chia Oil and Mucilage Nanoemulsion: Potential Strategy to Protect a Functional Ingredient

Sibele Santos Fernandes et al.

Summary: Nanoencapsulation enhances the stability and controlled release of bioactive compounds, and nanoemulsion technique can effectively protect chia oil from degradation. Chia mucilage is an excellent material for encapsulation due to its emulsification properties and retention capacities. Most studies on chia oil focus on microencapsulation, but chia oil nanoemulsion with chia mucilage represents a promising approach to maintain the functionality and oxidative stability of the oil.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2023)

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Article Nanoscience & Nanotechnology

Construction of Curcumin and Paclitaxel Co-Loaded Lipid Nano Platform and Evaluation of Its Anti-Hepatoma Activity in vitro and Pharmacokinetics in vivo

Yuxun Wei et al.

Summary: The study aimed to develop a co-loading platform encapsulating curcumin and paclitaxel, and to investigate their synergistic effects on liver cancer cells. The CU-PTX-LNP formulations showed excellent properties, including sustained release, stability, and high entrapment efficiency. In vitro and in vivo experiments demonstrated significant anti-tumor benefits and enhanced pharmacokinetic behavior of CU-PTX-LNP.

INTERNATIONAL JOURNAL OF NANOMEDICINE (2023)

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Article Pharmacology & Pharmacy

Chondroitin/Lactoferrin-dual functionalized pterostilbene-solid lipid nanoparticles as targeted breast cancer therapy

Sara Aly et al.

Summary: Breast cancer, the leading cause of cancer-associated mortality in women, requires novel therapeutic approaches. Pterostilbene (PTS), a phytochemical agent, shows promise against breast cancer but has limitations. In this study, PTS-loaded solid lipid nanoparticles (PTS-SLNs) were developed with active-targeting using lactoferrin (Lf) and chondroitinsulfate (CS). CS/Lf/PTS-SLNs exhibited desirable properties and demonstrated superior cytotoxicity, anti-migratory effect, and cellular uptake compared to PTS-solution in vitro. In an orthotopic cancer model, CS/Lf/PTS-SLNs showed improved anti-tumor efficacy and molecular-level effects. These findings highlight CS/Lf/PTS-SLNs as a promising nanoplatform for targeted-breast cancer therapy.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2023)

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Article Polymer Science

Preparation of melatonin novel-mucoadhesive nanoemulsion used in the treatment of depression

Niyaz Ahmad et al.

Summary: The study aims to develop a novel Melatonin-loaded nanoemulsion for improved solubility, and evaluate its efficacy and brain bioavailability in comparison to other forms of Melatonin. The optimized nanoformulation showed significant improvement in the treatment of depression, indicating the potential of this nanoemulsion.

POLYMER BULLETIN (2023)

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Article Pharmacology & Pharmacy

Assessment of anti-psoriatic activity of bakuchiol-loaded solid lipid nanoparticles-based gel: design, characterization, and mechanistic insight via NF-kB signaling pathway

Shivani Attri et al.

Summary: The aim of this study was to evaluate the anti-psoriatic potential of bakuchiol loaded solid lipid nanoparticles (SLNs) by modulating inflammatory and oxidative pathways. Bak-loaded SLNs were prepared and characterized. The release studies confirmed sustained release of Bak-SLNs-based gel. In a UV-B-induced psoriatic rat model, Bak showed significant anti-psoriatic effect via regulating inflammatory markers and levels of antioxidant enzymes. RT-qPCR analysis confirmed the downregulation of inflammatory markers by Bak. The study indicates that Bak-loaded SLNs-based gel can be a novel therapeutic approach for psoriasis.

NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY (2023)

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Article Biotechnology & Applied Microbiology

Umbelliferone loaded PEGylated liposomes: preparation, characterization and its mitigatory effects on Dalton's ascites lymphoma development

Prathapan Abeesh et al.

Summary: The study developed a liposomal delivery system to enhance the therapeutic efficacy of Umbelliferone (UB) against tumors. The nanoliposomes showed a particle size of 116 +/- 3.2 nm with a negative surface charge and encapsulation efficiency of 78%. In vitro and in vivo experiments demonstrated that the nanoliposomes significantly improved cellular uptake, apoptosis induction, and overall survivability compared to free UB.

3 BIOTECH (2023)

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Article Pharmacology & Pharmacy

Nanostructured Lipid Carriers Aimed to the Ocular Delivery of Mangiferin: In Vitro Evidence

Debora Santonocito et al.

Summary: The aim of this study was to investigate the capability of MGN-NLC as a potential drug delivery system for ocular administration. The in vitro and ex vivo results showed that MGN-NLC exhibited no cytotoxic effects, maintained the antioxidant role of MGN, and could permeate and accumulate in ocular tissues. These findings suggest a potential application of MGN-NLC in the treatment of oxidative stress-related ocular diseases.

PHARMACEUTICS (2023)

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Article Chemistry, Applied

Potential of curcumin and niacin-loaded targeted chitosan coated liposomes to activate autophagy in hepatocellular carcinoma cells: An in vitro evaluation in HePG2 cell line

Nemany A.N. Hanafy et al.

International Journal of Biological Macromolecules (2023)

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Article Biochemistry & Molecular Biology

Encapsulation of sesamol and retinol using alginate and chitosan-coated W/O/W multiple emulsions containing Tween 80 and Span 80

Shahryar Yousefi et al.

Summary: The production conditions of multiple W/O/W nanoemulsions containing sesamol and retinol were optimized using response surface methodology (RSM). Span 80, Tween 80, and water in oil ratio (W/O) were considered as independent variables, while encapsulation efficiency (EE%) and particle size were taken as dependent variables. An optimum sample with high EE% and small particle size was produced by adjusting the percentages of Span 80, Tween 80, and W/O. The release of sesamol and retinol was measured in simulated gastric fluid (SGF) and simulated intestinal fluid (SIF), showing different release rates.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2023)

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Article Pharmacology & Pharmacy

Development of thymol nanoemulsions with potential application in oral infections

Rodrigo Henrique Saatkamp et al.

Summary: Nanoemulsions loaded with thymol were prepared and tested for their efficacy in treating oral infections. The thymol-loaded nanoemulsions showed improved stability and enhanced distribution in the oral cavity. In addition, all tested nanoemulsions exhibited significant free-radical scavenging activity.

JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY (2023)

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Article Chemistry, Medicinal

Enhancing Oral Bioavailability and Brain Biodistribution of Perillyl Alcohol Using Nanostructured Lipid Carriers

Samila Horst Peczek et al.

Summary: This study developed nanostructured lipid carriers (NLCs) loaded with perillyl alcohol (POH) to improve its distribution in the brain. The results showed significantly enhanced oral bioavailability of POH when encapsulated in the NLCs, with increased concentration in brain tissue. This provides a potential therapeutic strategy for brain tumor treatment.

PHARMACEUTICALS (2023)

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Article Chemistry, Applied

Highly stable nanostructured lipid carriers containing candelilla wax for D-limonene encapsulation: Preparation, characterization and antifungal activity

Xin Wang et al.

Summary: The objective of this work was to develop nanostructured lipid carriers (NLCs) with preservation effect using pea protein isolate (PPI) nanoparticles as emulsifiers, candelilla wax (CW) as organo-gelator, and D-limonene (DL) as an antifungal agent. The optimal formulation parameters of NLCs were determined based on particle size, poly-dispersity index, and zeta potential, and further characterization of NLCs was performed. The addition of CW in NLCs resulted in improved dispersion, storage stability, and inhibition of DL release.

FOOD HYDROCOLLOIDS (2023)

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Article Ophthalmology

Compritol solid lipid nanoparticle formulations enhance the protective effect of betulinic acid derivatives in human Muller cells against oxidative injury

Zhengqi Cheng et al.

Summary: Muller cell dysfunction can lead to irreversible retinal diseases, with oxidative injury being a major cause. Encapsulating betulinic acid derivatives in solid lipid nanoparticles significantly enhances their cytoprotective effects in human Muller cells, improving efficacy and stability for potential treatment and prevention of retinal diseases.

EXPERIMENTAL EYE RESEARCH (2022)

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Article Pharmacology & Pharmacy

Alpha-Lipoic Acid and Cyanocobalamin Co-Loaded Nanoemulsions: Development, Characterization, and Evaluation of Stability

Ozlem Coban et al.

Summary: The study successfully developed an HPLC method for simultaneous determination of ALA and Vit B-12, with a correlation coefficient value of 0.9999 for both analytes. Nanoemulsions containing ALA and Vit B-12 prepared using castor oil and magnetic stirring showed better colloidal properties and stability, higher encapsulation efficiency, and release percentage. This study demonstrated that these nanoemulsions are stable at different temperatures and pH values.

JOURNAL OF PHARMACEUTICAL INNOVATION (2022)

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Article Pharmacology & Pharmacy

Bacteria-targeting liposomes for enhanced delivery of cinnamaldehyde and infection management

Nina Sang et al.

Summary: A multifunctional bacteria-targeting liposome was developed in this study, which demonstrated enhanced delivery of antibiotics and LPS neutralization. This approach shows promise in providing innovative insights for the treatment of persistent and severe bacterial infections.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2022)

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Article Pharmacology & Pharmacy

Eugenol encapsulation into conventional liposomes and chitosan-coated liposomes: A comparative study

Carine Sebaaly et al.

Summary: The aim of this study is to investigate the effect of chitosan coating layer and molecular weight on the characteristics of liposomes encapsulating eugenol. The results showed that the presence of chitosan coating layer increased the particle size of liposomes, and increasing chitosan molecular weight led to an increase in cholesterol incorporation. The incorporation rates of phospholipids and eugenol decreased in chitosomes. Chitosomes enhanced the antioxidant activity of eugenol and maintained its encapsulation after long-term storage.

JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY (2022)

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Article Pharmacology & Pharmacy

Formulation, optimization and evaluation of vitamin E TPGS emulsified dorzolamide solid lipid nanoparticles

Mohammed Shadab Shahab et al.

Summary: In this study, dorzolamide (DRZ) encapsulated solid lipid nanoparticles (SLNs) for ocular administration were successfully developed. The optimized SLNs demonstrated excellent release characteristics and enhanced transcorneal permeation in simulated tear fluids. Furthermore, the optimized SLNs were found to be safe and non-irritating for ocular delivery.

JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY (2022)

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Article Food Science & Technology

Liposomal encapsulation of omega-3 fatty acid and α-lipoic acid conjugate for cow milk fortification

Pintu Choudhary et al.

Summary: The study successfully encapsulated chia oil and LA in liposomes to enhance their stability and showed high encapsulation efficiency. Characterization of the LA inclusion complex and nanoliposome formulation was conducted, resulting in a novel method for co-delivery of omega-3 fatty acid and LA in fortified milk.

JOURNAL OF FOOD PROCESSING AND PRESERVATION (2022)

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Article Biochemistry & Molecular Biology

Solid Lipid Nanoparticles Administering Antioxidant Grape Seed-Derived Polyphenol Compounds: A Potential Application in Aquaculture

Adriana Trapani et al.

Summary: This study investigates the use of solid lipid nanoparticles (SLN) to deliver a mixture of antioxidant compounds to fish cells in aquaculture. The findings show that an SLN formulation containing Gelucire(R) 50/13 and Precirol(R) ATO5 can improve the viability and antioxidant properties of fish cells. This research may have significant implications in the field of aquaculture.

MOLECULES (2022)

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Article Chemistry, Multidisciplinary

Preparation of eugenol nanoemulsions for antibacterial activities

Xuan Fu et al.

Summary: In this study, eugenol nanoemulsion with high stability and good biological activity was successfully prepared using a high-speed shearing technique. The optimized nanoemulsion exhibited strong inhibition against Escherichia coli and Staphylococcus aureus, while having minimal impact on liver and lung cells, indicating good biocompatibility.

RSC ADVANCES (2022)

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Article Materials Science, Biomaterials

Folate-modified triptolide liposomes target activated macrophages for safe rheumatoid arthritis therapy

Rui-Bo Guo et al.

Summary: The folate-modified triptolide liposomes designed in this study showed specific targeting effects in treating RA and demonstrated low cytotoxicity and significant anti-inflammatory properties in vitro. In vivo experiments also indicated good cartilage protection and anti-inflammatory effects with lower toxicity compared to free triptolide, providing a promising new approach for RA treatment.

BIOMATERIALS SCIENCE (2022)

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Article Pharmacology & Pharmacy

Ultrasound Guided Intra-Articular Injection of Triptolide-loaded Solid Lipid Nanoparticle for Treatment of Antigen-Induced Arthritis in Rabbits

Shilin Li et al.

Summary: This study evaluated the efficacy of ultrasound-guided intra-articular injection of triptolide-loaded solid lipid nanoparticle (TP-SLN) for the treatment of antigen-induced arthritis in rabbits. The results showed that TP-SLN was more effective than triptolide and comparable to betamethasone in treating arthritis. Additionally, there was a significant correlation between ultrasonic scores and pathological scores, indicating that ultrasound can be a useful assessment tool for early arthritis.

FRONTIERS IN PHARMACOLOGY (2022)

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Article Biochemical Research Methods

Methods for preparation of nanostructured lipid carriers

Eman Gomaa et al.

Summary: Construction of nanocarriers, such as NLCs, has great potential in drug delivery systems. NLCs, as a new generation of solid lipid nanoparticles, have higher drug loading efficiency compared to SLNs and offer advantages in terms of preparation and scalability.

METHODS (2022)

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Article Chemistry, Medicinal

Fabrication and Evaluation of Quercetin Nanoemulsion: A Delivery System with Improved Bioavailability and Therapeutic Efficacy in Diabetes Mellitus

Manohar Mahadev et al.

Summary: The ultrasonically assisted quercetin nanoemulsion showed improved bioavailability and therapeutic effectiveness against diabetes in rats. The optimized nanoemulsion exhibited stability at various temperatures for 45 days and protective effects on the structures of pancreatic beta-cells and hepatocytes.

PHARMACEUTICALS (2022)

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Article Chemistry, Physical

Nanoemulsions with Amaranth and Sea Buckthorn Oils

Ya O. Ivanova et al.

Summary: Nanoemulsions (NEs) containing natural components, such as amaranth and sea buckthorn oils, have been studied for their stability. NEs stabilized with a mixture of Tween 80 and Span 80 showed instability to flocculation and creaming, while NEs stabilized with a mixture of Tween 60 and Span 60 were significantly more stable. The produced NEs of amaranth and sea buckthorn oils are stable to flocculation and creaming for a long time.

COLLOID JOURNAL (2022)

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Review Environmental Sciences

A critical look at challenges and future scopes of bioactive compounds and their incorporations in the food, energy, and pharmaceutical sector

Sanidhya Pai et al.

Summary: Bioactive compounds are secondary metabolites extracted from plants, fungi, microbes, or animals. Their applications range from food and pharmaceutical industries to cosmetics and bioremediation. Green solvents and non-conventional extraction methods are replacing traditional ones, promoting sustainable circular economy. Further development in microfluidics, optimization models, nanoencapsulation, and metabolic engineering is expected.

ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH (2022)

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Article Chemistry, Applied

Polyelectrolytes-stabilized liposomes for efficient encapsulation of Lactobacillus rhamnosus and improvement of its survivability under adverse conditions

Seyed Fakhreddin Hosseini et al.

Summary: In this study, nanoliposomes coated with chitosan-gelatin polyelectrolytes were successfully synthesized and characterized to improve the survivability of Lactobacillus rhamnosus probiotics, showing increased stability in simulated gastrointestinal fluids. This system may have potential applications as a carrier of probiotic cells in functional food development.

FOOD CHEMISTRY (2022)

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Article Food Science & Technology

Nanoemulsions: Techniques for the preparation and the recent advances in their food applications

K. Sneha et al.

Summary: Nanoemulsions, with droplet sizes ranging from 20 to 500 nm, have various applications in the food industry for improving quality and extending shelf life.

INNOVATIVE FOOD SCIENCE & EMERGING TECHNOLOGIES (2022)

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Review Biotechnology & Applied Microbiology

Phytochemical-loaded liposomes for anticancer therapy: an updated review

Vivek P. Chavda et al.

Summary: This review discusses the application of liposomal phyto-chemotherapy in cancer treatment, which aims to improve therapeutic effectiveness and reduce side effects through the use of liposomal nanovesicles for drug delivery and targeted therapy.

NANOMEDICINE (2022)

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Article Cell Biology

Application and Efficacy of Melatonin Elastic Liposomes in Photoaging Mice

Xueqin Hou et al.

Summary: This study demonstrated the effectiveness of elastic liposomes as a transdermal drug delivery system for melatonin. The optimized elastic liposomes showed small size, high encapsulation efficiency, and drug loading. In vitro permeation evaluation revealed that elastic liposomes had a higher penetration rate compared to conventional liposomes. The experiment results showed that topical application of melatonin-loaded elastic liposomes improved skin elasticity, hydration level, and preserved dermal collagen and elastic fibers.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2022)

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Article Pharmacology & Pharmacy

A Comparative Study on Inhibition of Breast Cancer Cells and Tumors in Mice by Carotenoid Extract and Nanoemulsion Prepared from Sweet Potato (Ipomoea batatas L.) Peel

Hsin-Yen Hsu et al.

Summary: The study aimed to determine the carotenoid composition in sweet potato peel and prepare carotenoid nanoemulsion to study its inhibitory effect on breast cancer cells and tumors in mice. Results showed that carotenoid nanoemulsion was more effective than carotenoid extract in inhibiting the growth of breast cancer cells and tumors. Additionally, both carotenoid extract and nanoemulsion could reduce the levels of growth factors in serum, with the nanoemulsion being more effective.

PHARMACEUTICS (2022)

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Article Materials Science, Multidisciplinary

A study on the role of eugenol encapsulated liposomes in facilitating neuron-microglia mediated wound recovery

Neeraja Revi et al.

Summary: This study investigates the inflammatory response of microglia induced by neuronal injury and its modulation by the anti-inflammatory formulation Eugenol encapsulated liposomes. The results show that treatment with Eugenol encapsulated liposomes decreases the production of pro-inflammatory microglia and promotes wound closure.

MATERIALIA (2022)

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Article Materials Science, Biomaterials

In Vitro Evaluation of Antitumor and Immunomodulatory Potential of Curcumin Nano-emulsion on Breast Cancer

Sara A. Youssry et al.

Summary: This study evaluated the modulatory effects of curcumin nano-emulsion (CR-NE) on immune markers in breast cancer. The results showed that CR-NE treatment significantly increased ASC levels while decreasing cytokine levels, proliferation rate, and Bc16 levels. CR-NE treatment was also associated with a decline in sCD163 levels. Therefore, CR-NE may be an effective drug delivery system to enhance the modulatory effects of curcumin on immune markers in breast cancer.

BIONANOSCIENCE (2022)

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Article Pharmacology & Pharmacy

Formulation of the novel structure curcumin derivative-loaded solid lipid nanoparticles: synthesis, optimization, characterization and anti-tumor activity screening in vitro

Ke Li et al.

Summary: This study investigated the effect of structural modification of Curcumin combined with the solid lipid nanoparticles drug delivery system on anti-tumor activity in vitro. The results showed that the modified Curcumin derivative CU1 had higher stability and anti-tumor activity compared to Curcumin, and CU1-SLN further enhanced the inhibition of tumor cells and reduced toxicity to normal cells.

DRUG DELIVERY (2022)

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Article Biochemistry & Molecular Biology

Nano-Liposomes Double Loaded with Curcumin and Tetrandrine: Preparation, Characterization, Hepatotoxicity and Anti-Tumor Effects

Jia-Wen Song et al.

Summary: This study encapsulated curcumin and tetrandrine in nano-liposomes and added a stabilizer to improve their physicochemical properties and anti-tumor effects. The nano-liposomes showed high stability, solubility, and strong inhibitory effect on various cancer cells, with no significant toxicity observed in zebrafish.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

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Article Nanoscience & Nanotechnology

A Cosmeceutical Topical Water-in-Oil Nanoemulsion of Natural Bioactives: Design of Experiment, in vitro Characterization, and in vivo Skin Performance Against UVB Irradiation-Induced Skin Damages

Carol Yousry et al.

Summary: This study aimed to develop and optimize a water-in-oil nanoemulsion loaded with collagen and/or vitamin C for skin protection against UV radiation. The optimized nanoemulsion showed good permeability and wound healing properties on skin cells and effectively protected the skin from UV damage in both in vitro and in vivo experiments. The mixture of collagen and vitamin C in the nanoemulsion had a more pronounced effect.

INTERNATIONAL JOURNAL OF NANOMEDICINE (2022)

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Article Biochemistry & Molecular Biology

Myricetin loaded in solid lipid nanoparticles induces apoptosis in the HT-29 colorectal cancer cells via mitochondrial dysfunction

Hadis Alidadi et al.

Summary: The study demonstrates that MCN-SLNs can effectively induce colon cancer cell death by increasing ROS formation and activating the apoptosis process.

MOLECULAR BIOLOGY REPORTS (2022)

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Article Food Science & Technology

Development of Lipid Nanoparticles Containing Omega-3-Rich Extract of Microalga Nannochlorpsis gaditana

Cristina Blanco-Llamero et al.

Summary: Microalgae are a new source of bioactive compounds with health-promoting properties, and can be considered as a valuable alternative to fish and krill oils. In this study, the extract of the microalga Nannochloropsis gaditana was obtained and analyzed. The optimal lipid nanoparticle formulation was developed using a factorial design approach. The developed formulations were found to be stable and had an encapsulation efficiency over 60%.

FOODS (2022)

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Article Pharmacology & Pharmacy

Liposomal beta-Sitosterol Suppresses Metastasis of CT26/luc Colon Carcinoma via Inhibition of MMP-9 and Evoke of Immune System

Chao-Yu Shen et al.

Summary: The liposomal encapsulated beta-sitosterol (LS) has been found to have a better inhibition effect on tumor metastasis with lower cytotoxicity compared to beta-sitosterol (SITO). Mice treated with LS showed significantly fewer metastases to the lungs and other tissues/organs, and higher levels of IL-12, IL-18, and IFN-gamma. The underlying mechanism may involve the inhibition of MMP-9 and the elicitation of an antitumoral Th1 immune response.

PHARMACEUTICS (2022)

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Article Biology

Recapsoma®: A Novel Mixture Based on Bergamot, Ipomoea Batatas, Policosanol Extracts and Liposomal Berberine for the Treatment of Hypercholesterolemia

Chiara Amante et al.

Summary: Cardiovascular disease is a major cause of mortality worldwide. Regular consumption of phenols is associated with a reduced risk of cardiovascular disease. Recapsoma (R), a mixture of natural substances, has shown anti-dyslipidaemic effects and can potentially be used as an alternative treatment for hypercholesterolemia.

LIFE-BASEL (2022)

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Article Food Science & Technology

Physicochemical properties, sensory acceptability, and antioxidant activity of chocolate bar fortified by solid lipid nanoparticles of gallic acid

Edy Subroto et al.

Summary: This study aimed to fortify chocolate bars with gallic acid encapsulated in solid lipid nanoparticles (SLN). The results showed that increasing the concentration of SLN-gallic acid improved the total phenolic content and antioxidant activity of the chocolate bars but adversely affected their color, texture, and organoleptic properties. The best treatment was found to be the addition of 5% SLN-gallic acid, which resulted in a desirable crystal morphology and was favored by the panelists.

INTERNATIONAL JOURNAL OF FOOD PROPERTIES (2022)

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Article Pharmacology & Pharmacy

Transferrin-functionalized liposomes loaded with vitamin VB12 for Alzheimer?s disease therapy

Stephanie Andrade et al.

Summary: This study developed a VB12-loaded liposome nanosystem capable of dual-targeting VB12 to the blood-brain barrier (BBB) and neuronal cells, delaying the formation of Aβ fibrils and disrupting mature fibrils. This research has significant potential for the prevention and treatment of AD.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2022)

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Article Pharmacology & Pharmacy

New Approach for Preparing Solid Lipid Nanoparticles with Volatile Oil-Loaded Quercetin Using the Phase-Inversion Temperature Method

Yotsanan Weerapol et al.

Summary: This study investigated the preparation of Quercetin-loaded solid lipid nanoparticles (SLNs) using a new approach with rosemary oil (RMO). Trilaurin (TLR) was found to be the most suitable solid lipid, producing small-sized and stable SLNs. By incorporating RMO with TLR at a 1:3 ratio, SLNs with high entrapment efficiency and sustained release of QCT were achieved. The use of RMO also enabled smaller sized SLNs. This novel method shows great potential for delivering poorly water-soluble compounds.

PHARMACEUTICS (2022)

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Article Chemistry, Medicinal

Preparation, in vitro and in vivo evaluation of pinocembrin-loaded TPGS modified liposomes with enhanced bioavailability and antihyperglycemic activity

Xinyi Shen et al.

Summary: This study successfully prepared polyethylene glycol succinate-vitamin E modified pinocembrin-loaded liposomes and evaluated their pharmacokinetics and antihyperglycemic activity. The PCBT-liposomes showed promising potential as a nano drug carrier and demonstrated improved water solubility, bioavailability, and antihyperglycemic activity of PCB.

DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY (2022)

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Article Food Science & Technology

Liposomes loading grape seed extract: A nanotechnological solution to reduce wine-making waste and obtain health-promoting products

Giane Engel Montagner et al.

Summary: Liposomes incorporating grape marc seed extract have been developed as a promising solution to reuse waste from the wine industry and produce nanotechnological products with high value for human health. These liposomes are stable, non-toxic to human cells, and exhibit antioxidant potential.

FUTURE FOODS (2022)

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Article Biotechnology & Applied Microbiology

Coumarin-Encapsulated Solid Lipid Nanoparticles as an Effective Therapy against Methicillin-Resistant Staphylococcus aureus

Mohammed H. Alqarni et al.

Summary: Bacterial infections caused by antibiotic-resistant pathogens are a significant public health problem. Develop innovative strategies to effectively eliminate antibiotic-resistant microorganisms are urgently needed. Coumarin has shown significant effectiveness against MRSA and can be used as an alternative treatment. Nanoparticle-based targeted therapies can effectively treat MRSA infections.

BIOENGINEERING-BASEL (2022)

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Review Engineering, Biomedical

Lipid Nanoparticles for Drug Delivery

Letao Xu et al.

Summary: This article provides an overview of lipid nanoparticles, including their different types, preparation methods, and applications in drug delivery. It also summarizes the challenges and potential future studies for lipid nanoparticles to achieve wider clinical and pharmaceutical applications.

ADVANCED NANOBIOMED RESEARCH (2022)

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Article Biology

DRUG RELEASE, STABILITY AND EFFICIENCY OF VITAMIN E LOADED IN LIPOSOMES FOR BOVINE SPERM PROTECTION IN CRYOPRESERVATION MEDIUM

Lamia Taouzinet et al.

Summary: This study successfully encapsulated alpha tocopherol into liposomes and demonstrated its stability and drug release effect in sperm cryopreservation. The use of vitamin E liposome preparations significantly improved sperm motility compared to other treatments, indicating potential applications.

CRYOLETTERS (2022)

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Article Integrative & Complementary Medicine

Formulation of Neem oil-loaded solid lipid nanoparticles and evaluation of its anti-Toxoplasma activity

Sara Nemati et al.

Summary: The study synthesized Neem oil-loaded solid lipid nanoparticles (NeO-SLNs) and evaluated their anti-Toxoplasma activity, demonstrating that NeO-SLNs can effectively kill Toxoplasma tachyzoites with acceptable cell toxicity. The encapsulation of Neem oil in SLNs also allows for prolonged release of the extract, indicating potential for targeting cyst stages in future research.

BMC COMPLEMENTARY MEDICINE AND THERAPIES (2022)

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Article Chemistry, Multidisciplinary

Liposome-based nanocapsules for the controlled release of dietary curcumin: PDDA and silica nanoparticle-coated DMPC liposomes enhance the fluorescence efficiency and anticancer activity of curcumin

Alaa K. Othman et al.

Summary: This study focuses on the enhancement of drug delivery properties by surface modification of liposomes. The encapsulation efficiency and anti-cancer activity of curcumin were improved by adding layers to the liposomes' surface, which resulted in a decrease in drug release. The fluorescence of curcumin was also enhanced significantly in the modified liposomes.

RSC ADVANCES (2022)

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Article Entomology

Insecticidal activity of solid lipid nanoparticle loaded by Ziziphora clinopodioides Lam. against Tribolium castaneum (Herbst, 1797) (Coleoptera: Tenebrionidae)

Fahimeh Hosseinpour Jajarm et al.

Summary: Solid lipid nanoparticles loaded with Ziziphora clinopodioides were synthesized and showed higher toxicity against Tribolium castaneum compared to pure oil. The formulation remained effective for up to 14 days, while the pure oil lost its toxicity after 8 days.

INTERNATIONAL JOURNAL OF PEST MANAGEMENT (2021)

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Article Instruments & Instrumentation

Anacardic acid encapsulated solid lipid nanoparticles forStaphylococcus aureusbiofilm therapy: chitosan and DNase coating improves antimicrobial activity

Md Meraj Anjum et al.

Summary: Biofilm mediated bacterial infections are key in infectious disease progression due to antimicrobial resistance evolution. Traditional antibiotics are inadequate due to increased resistance. Anacardic acid loaded solid lipid nanoparticles offer a promising alternative with enhanced efficacy against biofilm-mediated antimicrobial resistance.

DRUG DELIVERY AND TRANSLATIONAL RESEARCH (2021)

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Article Chemistry, Medicinal

Scolicidal and Apoptotic Activities of 5-hydroxy-1, 4-naphthoquinone as a Potent Agent against Echinococcus granulosus Protoscoleces

Masoud Moghadaszadeh et al.

Summary: This study evaluated the efficacy and apoptotic activity of liposomal system containing juglone against protoscoleces. Results showed that juglone nanoliposomes induced scolicidal effect at all tested concentrations, with the highest concentrations achieving 100% mortality within 60-120 minutes. Furthermore, higher caspase-3 mRNA expression was observed in PSCs treated with juglone nanoliposomes compared to control groups, suggesting a potent apoptotic effect.

PHARMACEUTICALS (2021)

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Review Pharmacology & Pharmacy

Ethanol injection technique for liposomes formulation: An insight into development, influencing factors, challenges and applications

Ahmed Gouda et al.

Summary: This review article provides an in-depth understanding of the ethanol injection method and its modifications for producing small unilamellar liposomes. It discusses various parameters influencing the outcome, such as injection velocity and stirring rate, as well as the limitations and pharmaceutical applications of the method.

JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY (2021)

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Article Radiology, Nuclear Medicine & Medical Imaging

γ-Tocotrienol-Loaded Liposomes for Radioprotection from Hematopoietic Side Effects Caused by Radiotherapeutic Drugs

Sang-gyu Lee et al.

Summary: A novel radioprotector drug, GT3-Nano, shows promising efficacy in mitigating bone marrow radiation damage during targeted radionuclide therapy in mice. GT3-Nano demonstrates significant radioprotection effects and facilitates rapid recovery of hematopoietic components in mice.

JOURNAL OF NUCLEAR MEDICINE (2021)

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Article Medicine, Research & Experimental

Enhanced antitumor efficacy of lapachol-loaded nanoemulsion in breast cancer tumor model

Sued Eustaquio Mendes Miranda et al.

Summary: Lapachol-loaded nanoemulsion (NE-LAP) was prepared and showed high antitumor activity. NE-LAP exhibited stable physicochemical characteristics, with encapsulation efficiency greater than 85%, and demonstrated higher cytotoxicity activity in vitro. Tc-99m-labeled NE-LAP showed prolonged blood circulation and tumor affinity in a tumor model.

BIOMEDICINE & PHARMACOTHERAPY (2021)

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Article Biophysics

Nutraceutical delivery through nano-emulsions: General aspects, recent applications and patented inventions

Ozgur Tarhan et al.

Summary: Nanostructured emulsions show significant potential in encapsulating, transporting, and delivering nutraceuticals in food and pharmaceutical applications. They provide enhanced stability and functionality for essential fatty acids, antioxidants, vitamins, and other bioactive compounds, improving bioavailability and protecting them from degradation. Various high- and low-energy methods are used to produce well-structured nanoemulsions, which are studied for nutraceutical delivery applications and cytotoxicity assessment. Numerous patented systems have been developed in the past three decades, demonstrating the ongoing innovation in food-grade nanoemulsions.

COLLOIDS AND SURFACES B-BIOINTERFACES (2021)

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Article Biochemistry & Molecular Biology

Investigation of the relaxing effect of a camphor nanoemulsion on rat isolated trachea

Maira M. Freitas et al.

Summary: The study evaluates the relaxing effect of nanoemulsified camphor (NEC) and its mechanism of action in isolated rat trachea. Results demonstrate that NEC promotes relaxation of isolated rat trachea when induced by carbachol (CCh) and potassium chloride (KCl) contraction. NEC may be involved with 8-adrenergic receptors, ATP-sensitive K+ channels, Ca2+-opened K+ channels, prostanoids, and TRPv receptor channels.

CHEMICO-BIOLOGICAL INTERACTIONS (2021)

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Article Pharmacology & Pharmacy

Improving protection effects of eucalyptol via carboxymethyl chitosan-coated lipid nanoparticles on hyperglycaemia-induced vascular endothelial injury in rats

Jianqing Peng et al.

Summary: In this study, carboxymethyl chitosan-coated lipid nanoparticles for eucalyptol were developed to enhance its protective effects on hyperglycaemia-induced vascular endothelial injury, and the mechanism of eucalyptol was confirmed. Pharmacokinetics data demonstrated that the nanocarrier promoted the oral absorption of eucalyptol.

JOURNAL OF DRUG TARGETING (2021)

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Article Biochemistry & Molecular Biology

Chitosan-coated liposome-containing carbamazepine and coenzyme Q10: design, optimization and evaluation

Ali Asram Sagiroglu

Summary: The study successfully developed chitosan-coated liposomal formulations encapsulating CBZ and CoQ10 with high encapsulation efficiency, particle size, and drug release characteristics, offering a promising approach for the treatment of epilepsy.

JOURNAL OF LIPOSOME RESEARCH (2021)

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Article Nanoscience & Nanotechnology

Capsaicin-loaded solid lipid nanoparticles: design, biodistribution, in silico modeling and in vitro cytotoxicity evaluation

Selvaraj Kunjiappan et al.

Summary: Lower doses of capsaicin have the potential to be effective as an anticancer drug, but factors like pungency, irritant effect, poor water solubility, and off-target effects limit its therapeutic use. The study demonstrated that capsaicin loaded SLNs could be stable in circulation for up to 3 days, providing controlled release and enhanced anticancer activity, particularly in human hepatocellular carcinoma.

NANOTECHNOLOGY (2021)

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Article Immunology

Paeoniflorin-loaded pH-sensitive liposomes alleviate synovial inflammation by altering macrophage polarity via STAT signaling

Dongyi Wang et al.

Summary: The study demonstrated that Pae-LS can effectively suppress synovial inflammation of CIA rats by regulating macrophage polarization via STAT signaling, showing potential for Rheumatoid Arthritis treatment as liposome delivery carrier systems.

INTERNATIONAL IMMUNOPHARMACOLOGY (2021)

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Article Pharmacology & Pharmacy

A Novel Drug Delivery System: the Encapsulation of Naringenin in Metal-Organic Frameworks into Liposomes

Zhangjie Wang et al.

Summary: Poorly water-soluble naringenin was loaded into porous MOFs to form NAR@ZIF-8 inclusion complex, which was then encapsulated into liposomes to create a novel drug delivery system. The liposomes system showed spherical shape, uniform particle size distribution, and complete structure. NAR@ZIF-8 liposomes exhibited more sustained drug release and higher inhibition efficiency on cancer cells compared to free NAR and NAR@ZIF-8.

AAPS PHARMSCITECH (2021)

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Review Pharmacology & Pharmacy

Overcoming barriers by local drug delivery with liposomes

S. G. Antimisiaris et al.

Summary: Localized or topical drug administration, in combination with nanoparticulate formulations like liposomes, can offer advantages such as prolonged retention of high drug loads, controlled release, reduced side effects, and increased protection from harsh environments. Targeted liposomal formulations may enhance these therapeutic advantages in drug delivery.

ADVANCED DRUG DELIVERY REVIEWS (2021)

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Article Biochemistry & Molecular Biology

Hypericin-loaded oil-in-water nanoemulsion synthesized by ultrasonication process enhances photodynamic therapy efficiency

Hui Ling Ma et al.

Summary: In this study, Hypericin-loaded oil-in-water nanoemulsions (NEs) were successfully produced to enhance the solubility and bioavailability of Hypericin. The physical and biological properties of the NEs were characterized, showing significant cytotoxic effects against breast cancer cells. The results suggest that the Hypericin-loaded NEs could be a promising approach for enhancing the efficacy of Hypericin in cancer treatment.

JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY (2021)

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Article Biochemistry & Molecular Biology

Encapsulation of α-Pinene in Delivery Systems Based on Liposomes and Cyclodextrins

Zahraa Hammoud et al.

Summary: The study investigated the encapsulation of alpha-pinene in different formulations to improve its application, determining parameters such as encapsulation efficiency and carrier stability. The results showed efficient encapsulation of alpha-pinene, with Lipoid S100 CLs exhibiting higher performance as a carrier.

MOLECULES (2021)

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Article Nanoscience & Nanotechnology

Formulation and Characterization of Phytostanol Ester Solid Lipid Nanoparticles for the Management of Hypercholesterolemia: An ex vivo Study

Sony Chandi Shrestha et al.

Summary: In this study, solid lipid nanoparticles containing phytostanol esters were successfully formulated and characterized. The optimized formulation showed high drug entrapment efficiency, good drug loading, and excellent nanoparticle yield. The nanoparticles exhibited spherical shape, negative surface charge, and demonstrated biological safety and uptake in hepatic and intestinal cell lines. These findings suggest that the formulation has the potential to serve as an innovative drug delivery system for phytostanols, contributing to better management of cardiovascular diseases.

INTERNATIONAL JOURNAL OF NANOMEDICINE (2021)

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Article Engineering, Chemical

Carotenoid nanoemulsions stabilized by natural emulsifiers: Whey protein, gum Arabic, and soy lecithin

Enrique Flores-Andrade et al.

Summary: The oil-in-water nanoemulsions of paprika oleoresin stabilized with soy lecithin, whey protein concentrate and gum Arabic showed good physical and chemical stability, with particle size influenced by interfacial tension. The stability of carotenoids in nanoemulsions was associated with changes in interfacial tension, PDI and entropy.

JOURNAL OF FOOD ENGINEERING (2021)

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Article Chemistry, Medicinal

Nanoemulsion for Improving the Oral Bioavailability of Hesperetin: Formulation Optimization and Absorption Mechanism

Fanyu Zeng et al.

Summary: By preparing a nanoemulsion vehicle, the oral bioavailability of hesperetin was significantly improved, with a notable increase in lymphatic transport and absorption in the intestine.

JOURNAL OF PHARMACEUTICAL SCIENCES (2021)

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Article Biochemistry & Molecular Biology

Cyto/Biocompatibility of Dopamine Combined with the Antioxidant Grape Seed-Derived Polyphenol Compounds in Solid Lipid Nanoparticles

Adriana Trapani et al.

Summary: The study aimed to co-administer dopamine (DA) and grape seed-derived proanthocyanidins (GSE) using Solid Lipid Nanoparticles (SLN) to increase neurotransmitter levels and reduce oxidative stress related to Parkinson's disease. Results showed that GSE on SLN surface effectively prevented DA autoxidation and enhanced cell viability when co-administered with the neurotoxin 6-hydroxydopamine. The SLN formulations containing DA and GSE have potential for non-invasive nose-to-brain delivery.

MOLECULES (2021)

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Article Pharmacology & Pharmacy

Transmucosal Solid Lipid Nanoparticles to Improve Genistein Absorption via Intestinal Lymphatic Transport

Antonella Obinu et al.

Summary: In this study, solid lipid nanoparticles (SLN) loaded with GEN were developed to improve its oral bioavailability by avoiding first-pass metabolism through intestinal lymphatic absorption. The SLN obtained by hot homogenization showed high stability and drug loading capacity.

PHARMACEUTICS (2021)

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Article Chemistry, Applied

Inhibition of growth and metastasis of breast cancer by targeted delivery of 17-hydroxy-jolkinolide B via hyaluronic acid-coated liposomes

Dan Liu et al.

Summary: Hyaluronic acid-coated liposomes targeted the delivery of 17-hydroxy-jolkinolide B with increased cytotoxicity and cellular uptake via CD44 receptor-mediated endocytosis. These liposomes suppressed cell migration and invasion, inhibited epithelial-mesenchymal transition, and demonstrated notable growth inhibition on tumor spheroids. In vivo experiments on mice showed strong tumor targeting and suppression abilities, making them a promising therapy for metastatic breast cancer.

CARBOHYDRATE POLYMERS (2021)

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Review Environmental Sciences

A review of dietary phytochemicals and their relation to oxidative stress and human diseases

Ruirui Guan et al.

Summary: Phytochemicals found in plant-based diets have beneficial effects on reducing oxidative stress and preventing various diseases, suggesting a diet rich in fruits, vegetables, and grains.

CHEMOSPHERE (2021)

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Article Nanoscience & Nanotechnology

Antitumor Effect of Hyperoside Loaded in Charge Reversed and Mitochondria-Targeted Liposomes

Yufei Feng et al.

Summary: The novel dual-functional liposome system possessing both extracellular charge reversal and mitochondrial targeting properties significantly enhances drug accumulation in mitochondria and triggers apoptosis of cancer cells. The results demonstrate that the charge reversed and mitochondria-targeted liposomes facilitate cellular internalization and mitochondrial accumulation for enhanced antitumor effect. Therefore, this liposome system represents a promising anticancer drug delivery system for improved therapeutic efficacy.

INTERNATIONAL JOURNAL OF NANOMEDICINE (2021)

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Article Food Science & Technology

Development of Hydrolysis Probe-Based qPCR Assays for Panax ginseng and Panax quinquefolius for Detection of Adulteration in Ginseng Herbal Products

Prasad Kesanakurti et al.

Summary: Authentication of Panax ginseng and Panax quinquefolius herbal dietary supplements is crucial in mitigating adulteration and substitution issues in the international ginseng supply chain. Species-specific hydrolysis probe qPCR assays have been developed and validated, demonstrating high specificity and reliability for the identification of target species in raw materials.

FOODS (2021)

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Article Food Science & Technology

Antifungal effect of cinnamaldehyde, eugenol and carvacrol nanoemulsion against Penicillium digitatum and application in postharvest preservation of citrus fruit

Ruopeng Yang et al.

Summary: The study successfully encapsulated eugenol, carvacrol, and cinnamaldehyde in oil-in-water nanoemulsion using high pressure microfludizer, which showed significant antifungal effects against Penicillium digitatum and prolonged the storage period of citrus fruits by delaying degradation and maintaining antioxidant enzyme activities.

LWT-FOOD SCIENCE AND TECHNOLOGY (2021)

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Editorial Material Pharmacology & Pharmacy

Pharmacokinetic Drug-Drug Interactions and Herb-Drug Interactions

Min-Koo Choi et al.

PHARMACEUTICS (2021)

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Article Medicine, Research & Experimental

Paclitaxel and naringenin-loaded solid lipid nanoparticles surface modified with cyclic peptides with improved tumor targeting ability in glioblastoma multiforme

Liying Wang et al.

Summary: This study systematically developed solid lipid nanoparticles (SLNs) loaded with paclitaxel and naringenin for the treatment of glioblastoma multiforme (GBM). Through risk assessment and optimization design, dual drug-loaded SLNs with good formulation quality were prepared, showing better biological effects than traditional drug solutions.

BIOMEDICINE & PHARMACOTHERAPY (2021)

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Article Biophysics

Ruthenium(II)-curcumin liposome nanoparticles: Synthesis, characterization, and their effects against cervical cancer

Buddolla Anantha Lakshmi et al.

Summary: Ruthenium-based metal complexes incorporating curcumin were synthesized, loaded into liposomes to form Ru-Cur loaded liposome nanoparticles (RCLNPs), and demonstrated significant anticancer properties in cervical cancer cells.

COLLOIDS AND SURFACES B-BIOINTERFACES (2021)

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Article Agricultural Engineering

Modified lignin from sugarcane bagasse as an emulsifier in oil-in-water nanoemulsions

Livia Beatriz Brenelli et al.

Summary: The use of modified lignin as an emulsifier for oil-in-water nanoemulsions was found to influence the size of the oil droplets formed. Zeta potential measurements can predict the long-term stability of nanoemulsions. Oxidation experiments showed that smaller droplet sizes led to higher oxidation rates, although still below the threshold values.

INDUSTRIAL CROPS AND PRODUCTS (2021)

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Article Pharmacology & Pharmacy

Synthesis of naringenin loaded lipid based nanocarriers and their in-vivo therapeutic potential in a rheumatoid arthritis model

Adil Munir et al.

Summary: This study aimed to enhance the therapeutic potential of natural flavonoids in rheumatoid arthritis treatment by using lipid-based nanocarriers. The results showed that NAR-loaded lipid nanocarriers had superior anti-inflammatory effects compared to sole NAR, with SL carriers being the most effective.

JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY (2021)

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Article Pharmacology & Pharmacy

Linseed Oil Nanoemulsions for treatment of Atopic Dermatitis disease: Formulation, characterization, in vitro and in silico evaluations

Ilke Kildaci et al.

Summary: The study focused on preparing and characterizing nanoemulsion formulations containing linseed oil for treating atopic dermatitis. Through stability tests and in vitro evaluation, the most suitable formulation was identified, showing potential as a drug candidate for AD treatment.

JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY (2021)

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Article Biotechnology & Applied Microbiology

Licochalcone A-loaded solid lipid nanoparticles improve antischistosomal activity in vitro and in vivo

Livia Mara Silva et al.

Summary: This study successfully isolated LicoA from licorice, encapsulated it in L-SLNs, and demonstrated its effective in vivo efficacy against Schistosoma mansoni. The findings suggest that L-SLNs can effectively reduce worm burden and may serve as a promising delivery system for treating S. mansoni infections.

NANOMEDICINE (2021)

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Article Toxicology

Prophylactic effect of probiotics fortified with Aloe vera pulp nanoemulsion against ethanol-induced gastric ulcer

Jihan Hussein et al.

Summary: The study showed that probiotics fortified with Aloe vera pulp nanoemulsion significantly reduced oxidative stress induced by ethanol and improved the release of various inflammatory mediators, indicating a promising approach for protection against gastric ulcers.

TOXICOLOGY MECHANISMS AND METHODS (2021)

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Review Chemistry, Multidisciplinary

Analytical Methods for Exploring Nutraceuticals Based on Phenolic Acids and Polyphenols

Oscar Vidal-Casanella et al.

Summary: This article highlights the importance of phenolic acids, flavonoids, and other polyphenols as the biologically active components of nutraceuticals, and the use of liquid chromatography for their characterization and quantification. The purification of plant extracts enriched in phenolic compounds for the development of nutraceutical products is discussed.

APPLIED SCIENCES-BASEL (2021)

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Article Chemistry, Applied

Formulation of Kaempferol in Nanostructured Lipid Carriers (NLCs): A Delivery Platform to Sensitization of MDA-MB468 Breast Cancer Cells to Paclitaxel

Toofan Aghazadeh et al.

Summary: Drug delivery-based nanoparticles loaded with Kaempferol in nanostructured lipid carriers show promising results in promoting apoptosis and inhibiting proliferation of breast cancer cells, enhancing the efficacy of paclitaxel. The study demonstrates that KAE-loaded NLCs can effectively reduce cell proliferation and increase the percentage of apoptosis in breast cancer cells.

BIOINTERFACE RESEARCH IN APPLIED CHEMISTRY (2021)

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Review Nanoscience & Nanotechnology

Current Trends and Challenges in Pharmacoeconomic Aspects of Nanocarriers as Drug Delivery Systems for Cancer Treatment

Sylwia Milewska et al.

Summary: Nanotherapy, utilizing nanoparticles as carriers to deliver drugs, offers a targeted approach to resolving various problems, particularly in cancer treatment. The carrier's crucial role in handling challenges, such as protecting drugs and overcoming resistance mechanisms within cells, has contributed to the success of nanotherapy.

INTERNATIONAL JOURNAL OF NANOMEDICINE (2021)

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Article Multidisciplinary Sciences

Optimization of extraction conditions of phenolic compounds from Cymbopogon citratus and evaluation of phenolics and aroma profiles of extract

Wiyeh Claudette Bakisu Muala et al.

Summary: The decoction extraction procedure was used to extract phenolic compounds from C. citratus leaves. The results showed that under optimal conditions, the extract had a high total polyphenol content and antioxidant activity, with caffeic and syringic acids as the main phenolic compounds. The lemongrass extract can be a potential natural source of antioxidants and aroma compounds for different industrial applications.

HELIYON (2021)

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Proceedings Paper Materials Science, Multidisciplinary

Solid lipid nanoparticles for oral drug delivery

S. Khaleel Basha et al.

Summary: Solid lipid nanoparticles (SLNs) are a versatile drug delivery platform with advantages such as good stability, uniform size, and high cell penetration efficiency, making them promising for controlled and site-specific drug delivery. Various instrumental techniques have been reviewed for the oral administration of SLNs.

MATERIALS TODAY-PROCEEDINGS (2021)

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Proceedings Paper Materials Science, Multidisciplinary

Soy protein incorporated nanoemulsion for enhanced stability of probiotic (Lactobacillus delbrueckii subsp. bulgaricus) and its characterization

Saravanakumar Vaishanavi et al.

Summary: Nanoemulsion delivery systems are thermodynamically stable and efficient in encapsulating bioactive compounds, improving their bioavailability. Probiotics were encapsulated in the nanoemulsion for enhanced viability during storage. The formulated nanoemulsion with specific components showed good emulsifying capacity, with the probiotic organism Lactobacillus delbrueckii subsp. bulgaricus successfully incorporated. The stability and viability of the optimized probiotic nanoemulsion were confirmed for potential use in food products.

MATERIALS TODAY-PROCEEDINGS (2021)

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Article Materials Science, Biomaterials

pH-Sensitive branched beta-glucan-modified liposomes for activation of antigen presenting cells and induction of antitumor immunity

Shin Yanagihara et al.

Summary: The study utilized branched beta-glucan as a naturally immune-stimulating and biocompatible material to develop multifunctional liposomal cancer vaccines that efficiently interacted with APCs and activated cells. The Aqua beta derivative-modified liposomes were pH-sensitive and capable of releasing their contents in response to weakly acidic pH, leading to efficient interaction with dendritic cells and induction of antitumor immune responses within the tumor microenvironment.

JOURNAL OF MATERIALS CHEMISTRY B (2021)

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Article Biochemistry & Molecular Biology

Enhanced antitumor efficacy and attenuated cardiotoxicity of doxorubicin in combination with lycopene liposomes

Jinfang Zhu et al.

JOURNAL OF LIPOSOME RESEARCH (2020)

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Article Chemistry, Applied

Targeted delivery and apoptosis induction of trans-resveratrol-ferulic acid loaded chitosan coated folic acid conjugate solid lipid nanoparticles in colon cancer cells

Chinnaiyan Senthil Kumar et al.

CARBOHYDRATE POLYMERS (2020)

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Article Chemistry, Applied

Enhancing the oral bioavailability of curcumin using solid lipid nanoparticles

Choongjin Ban et al.

FOOD CHEMISTRY (2020)

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Article Biochemistry & Molecular Biology

Assembly and Characterization of Biocompatible Coenzyme Q10-Enriched Lipid Nanoparticles

Anthony Moschetti et al.

LIPIDS (2020)

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Article Food Science & Technology

Liposome-chitosan hydrogel bead delivery system for the encapsulation of linseed oil and quercetin: Preparation and in vitro characterization studies

Juan Huang et al.

LWT-FOOD SCIENCE AND TECHNOLOGY (2020)

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Article Food Science & Technology

In vitro and In vivo antioxidant properties of paprika carotenoids nanoemulsions

M. P. Jimenez-Escobar et al.

LWT-FOOD SCIENCE AND TECHNOLOGY (2020)

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Article Nanoscience & Nanotechnology

Vitamin lipid nanoparticles enable adoptive macrophage transfer for the treatment of multidrug-resistant bacterial sepsis

Xucheng Hou et al.

NATURE NANOTECHNOLOGY (2020)

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Article Pharmacology & Pharmacy

Curcumin-Loaded Solid Lipid Nanoparticles Bypass P-Glycoprotein Mediated Doxorubicin Resistance in Triple Negative Breast Cancer Cells

Gamal-Eldein Fathy Abd-Ellatef et al.

PHARMACEUTICS (2020)

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Article Food Science & Technology

Influence of Ternary Emulsifier Mixtures on Oxidative Stability of Nanoemulsions Based on Avocado Oil

Natalia Riquelme et al.

FOODS (2020)

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Article Chemistry, Analytical

HPTLC-bioautography/SERS screening nifedipine adulteration in food supplement based on Ginkgo biloba

Yisheng Chen et al.

MICROCHEMICAL JOURNAL (2020)

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Article Nanoscience & Nanotechnology

Nano magnetic liposomes-encapsulated parthenolide and glucose oxidase for ultra-efficient synergistic antitumor therapy

Wenbin Gao et al.

NANOTECHNOLOGY (2020)

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Article Food Science & Technology

Enhanced oral bioavailability and bioefficacy of phloretin using mixed polymeric modified self-nanoemulsions

Yiling Wang et al.

FOOD SCIENCE & NUTRITION (2020)

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Article Chemistry, Multidisciplinary

Cationic and temperature-sensitive liposomes loaded with eugenol for the application to silk

Zhiguo Lu et al.

CHINESE CHEMICAL LETTERS (2020)

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Article Pharmacology & Pharmacy

Oral co-delivery nanoemulsion of 5-fluorouracil and curcumin for synergistic effects against liver cancer

Pu Guo et al.

EXPERT OPINION ON DRUG DELIVERY (2020)

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Article Food Science & Technology

Antimicrobial, Aflatoxin B1Inhibitory and Lipid Oxidation Suppressing Potential of Anethole-Based Chitosan Nanoemulsion as Novel Preservative for Protection of Stored Maize

Anand Kumar Chaudhari et al.

FOOD AND BIOPROCESS TECHNOLOGY (2020)

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Article Biochemistry & Molecular Biology

Encapsulation of lycopene within oil-in-water nanoemulsions using lactoferrin: Impact of carrier oils on physicochemical stability and bioaccessibility

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Preparation, Characterization and in vivo Study of Borneol-Baicalin-Liposomes for Treatment of Cerebral Ischemia-Reperfusion Injury

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INTERNATIONAL JOURNAL OF NANOMEDICINE (2020)

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Conjugated linoleic acid loaded nanostructured lipid carrier as a potential antioxidant nanocarrier for food applications

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FOOD SCIENCE & NUTRITION (2020)

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Preparation and cytotoxicity of lipid nanocarriers containing a hydrophobic flavanone

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Curcumin-loaded liposomes prepared from bovine milk and krill phospholipids: Effects of chemical composition on storage stability, in-vitro digestibility and anti-hyperglycemic properties

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FOOD RESEARCH INTERNATIONAL (2020)

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Ultrasound-assisted production of palm oil-based isotonic W/O/W multiple nanoemulsion encapsulating both hydrophobic tocotrienols and hydrophilic caffeic acid with enhanced stability using oil-based Sucragel

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Rana chensinensis Ovum Oil Based on CO2 Supercritical Fluid Extraction: Response Surface Methodology Optimization and Unsaturated Fatty Acid Ingredient Analysis

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Lipid Nanoparticles for Enhancing the Physicochemical Stability and Topical Skin Delivery of Orobol

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Baicalin Liposome Alleviates Lipopolysaccharide-Induced Acute Lung Injury in Mice via Inhibiting TLR4/JNK/ERK/NF-κB Pathway

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beta-Sitosterol-loaded solid lipid nanoparticles ameliorate complete Freund's adjuvant-induced arthritis in rats: involvement of NF-kappa B and HO-1/Nrf-2 pathway

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Nanoemulsification of Rice Bran Wax Policosanol Enhances Its Cardio-protective Effects via Modulation of Hepatic Peroxisome Proliferator-activated Receptor gamma in Hyperlipidemic Rats

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A systematic review on nanoencapsulation of food bioactive ingredients and nutraceuticals by various nanocarriers

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Composition design and medical application of liposomes

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Nanoemulsion formation by the phase inversion temperature method using polyoxypropylene surfactants

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In vitro cytotoxicity and anticancer effects of citral nanostructured lipid carrier on MDA MBA-231 human breast cancer cells

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Vitamin E Loaded Naringenin Nanoemulsion via Intranasal Delivery for the Management of Oxidative Stress in a 6-OHDA Parkinson's Disease Model

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Co-Delivery of Eugenol and Dacarbazine by Hyaluronic Acid-Coated Liposomes for Targeted Inhibition of Survivin in Treatment of Resistant Metastatic Melanoma

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In vitro skin permeation/retention of daidzein, genistein and glycitein from a soybean isoflavone rich fraction-loaded nanoemulsions and derived hydrogels

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Preparation of vitamin C liposomes by rapid expansion of supercritical solution process: Experiments and optimization

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Stability and characterization of O/W free phytosterols nanoemulsions formulated with an enzymatically modified emulsifier

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Effect of Surfactant Concentrations on Physicochemical Properties and Functionality of Curcumin Nanoemulsions Under Conditions Relevant to Commercial Utilization

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Preparation of Nanoemulsions of Vitamin A and C by Microfluidization: Efficacy on the Expression Pattern of Milk-Specific Proteins in MAC-T Cells

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Development and in vivo evaluation of baicalin-loaded W/O nanoemulsion for lymphatic absorption

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Liposomal Vitamin D3 as an Anti-aging Agent for the Skin

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Developing curcumin nanoemulsions by high-intensity methods: Impact of ultrasonication and microfluidization parameters

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Hepatoprotective and Renoprotective Properties of Lovastatin-Loaded Ginger and Garlic Oil Nanoemulsomes: Insights into Serum Biological Parameters

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Enhanced Subcellular Trafficking of Resveratrol Using Mitochondriotropic Liposomes in Cancer Cells

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Hybrid Ofloxacin/eugenol co-loaded solid lipid nanoparticles with enhanced and targetable antimicrobial properties

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Effect of lipid type, dispersed phase volume fraction and emulsifier on the physicochemical properties of nanoemulsions fortified with conjugated linoleic acid (CLA): Process optimization and stability assessment during storage conditions

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Preparation and Pharmacokinetic Study of Daidzein Long-Circulating Liposomes

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Modern Extraction and Purification Techniques for Obtaining High Purity Food-Grade Bioactive Compounds and Value-Added Co-Products from Citrus Wastes

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Chamomile oil loaded solid lipid nanoparticles: A naturally formulated remedy to enhance the wound healing

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Effect of lyophilization on food grade liposomes loaded with conjugated linoleic acid

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Preparation of a novel curcumin nanoemulsion by ultrasonication and its comparative effects in wound healing and the treatment of inflammation

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EGCG intestinal absorption and oral bioavailability enhancement using folic acid-functionalized nanostructured lipid carriers

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Iron chelation by curcumin suppresses both curcumin-induced autophagy and cell death together with iron overload neoplastic transformation

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CELL DEATH DISCOVERY (2019)

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Essential oil-loaded lipid nanoparticles for wound healing

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Production and characterization of nanostructured lipid carriers and solid lipid nanoparticles containing lycopene for food fortification

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JOURNAL OF FOOD SCIENCE AND TECHNOLOGY-MYSORE (2018)

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Liposomal Curcumin Targeting Endometrial Cancer Through the NF-κB Pathway

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CELLULAR PHYSIOLOGY AND BIOCHEMISTRY (2018)

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Physical properties of oil-in-water nanoemulsions stabilized by OSA-modified starch for the encapsulation of lycopene

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COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS (2018)

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Comparative Effects of Cholesterol and -Sitosterol on the Liposome Membrane Characteristics

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Nano-liposomes of lycopene reduces ischemic brain damage in rodents by regulating iron metabolism

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FREE RADICAL BIOLOGY AND MEDICINE (2018)

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NIR triggered liposome gold nanoparticles entrapping curcumin as in situ adjuvant for photothermal treatment of skin cancer

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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2018)

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Optimization of cinnamon oil nanoemulsions using phase inversion temperature method: Impact of oil phase composition and surfactant concentration

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Formation of capsaicin loaded nanoemulsions with high pressure homogenization and ultrasonication

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The Encapsulation of Lycopene in Nanoliposomes Enhances Its Protective Potential in Methotrexate-Induced Kidney Injury Model

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OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2018)

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FRONTIERS IN CHEMISTRY (2018)

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Development and Characterization of Solid Lipid Nanoparticles Containing Herbal Extract: In Vivo Antidepressant Activity

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Optimization of nutraceutical coenzyme Q10 nanoemulsion with improved skin permeability and anti-wrinkle efficiency

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Quercetin-Loaded Solid Lipid Nanoparticle Dispersion with Improved Physicochemical Properties and Cellular Uptake

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AAPS PHARMSCITECH (2017)

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Design of fish oil-in-water nanoemulsion by microfluidization

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INNOVATIVE FOOD SCIENCE & EMERGING TECHNOLOGIES (2017)

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Editorial Material Biotechnology & Applied Microbiology

Challenges associated and approaches for successful translation of nanomedicines into commercial products

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NANOMEDICINE (2017)

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γ-Oryzanol nanoemulsions produced by a low-energy emulsification method: an evaluation of process parameters and physicochemical stability

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Phosphatidylcholine with conjugated linoleic acid in fabrication of novel lipid nanocarriers

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COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS (2017)

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Solid lipid nanoparticles improve octyl gallate antimetastatic activity and ameliorate its renal and hepatic toxic effects

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Design, characterization and in vitro evaluation of linalool-loaded solid lipid nanoparticles as potent tool in cancer therapy

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Preparation and stability of astaxanthin solid lipid nanoparticles based on stearic acid

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EUROPEAN JOURNAL OF LIPID SCIENCE AND TECHNOLOGY (2016)

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Design and evaluation of lipoprotein resembling curcumin-encapsulated protein-free nanostructured lipid carrier for brain targeting

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INTERNATIONAL JOURNAL OF PHARMACEUTICS (2016)

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Encapsulation of (-)-epigallocatechin gallate into liposomes and into alginate or chitosan microparticles reinforced with liposomes

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JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE (2016)

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Nanoscale Delivery of Resveratrol towards Enhancement of Supplements and Nutraceuticals

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NUTRIENTS (2016)

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Nose to brain delivery of astaxanthin-loaded solid lipid nanoparticles: fabrication, radio labeling, optimization and biological studies

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Article Biotechnology & Applied Microbiology

Brain-targeted delivery of resveratrol using solid lipid nanoparticles functionalized with apolipoprotein E

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JOURNAL OF NANOBIOTECHNOLOGY (2016)

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Hepatoprotective effects of sesamol loaded solid lipid nanoparticles in carbon tetrachloride induced sub-chronic hepatotoxicity in rats

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ENVIRONMENTAL TOXICOLOGY (2016)

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Review Food Science & Technology

Food and Dietary Supplement Package Labeling-Guidance from FDA's Warning Letters and Title 21 of the Code of Federal Regulations

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Sesamol loaded solid lipid nanoparticles: a promising intervention for control of carbon tetrachloride induced hepatotoxicity

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BMC COMPLEMENTARY AND ALTERNATIVE MEDICINE (2015)

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Meeting Abstract Oncology

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CANCER RESEARCH (2015)

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A novel LDL-mimic nanocarrier for the targeted delivery of curcumin into the brain to treat Alzheimer's disease

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COLLOIDS AND SURFACES B-BIOINTERFACES (2015)

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Ultra-small lipid nanoparticles promote the penetration of coenzyme Q10 in skin cells and counteract oxidative stress

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EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS (2015)

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Neuroprotective potential of sesamol and its loaded solid lipid nanoparticles in ICV-STZ-induced cognitive deficits: Behavioral and biochemical evidence

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EUROPEAN JOURNAL OF PHARMACOLOGY (2015)

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Stability of bioactive solid lipid nanoparticles loaded with herbal extracts when exposed to simulated gastrointestinal tract conditions

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FOOD RESEARCH INTERNATIONAL (2015)

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Cationic solid lipid nanoparticles enhance ocular hypotensive effect of melatonin in rabbit

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INTERNATIONAL JOURNAL OF PHARMACEUTICS (2015)

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Article Pharmacology & Pharmacy

Effect of Baicalin-loaded PEGylated cationic solid lipid nanoparticles modified by OX26 antibody on regulating the levels of baicalin and amino acids during cerebral ischemia-reperfusion in rats

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INTERNATIONAL JOURNAL OF PHARMACEUTICS (2015)

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Physicochemical characterization of lycopene-loaded nanostructured lipid carrier formulations for topical administration

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INTERNATIONAL JOURNAL OF PHARMACEUTICS (2015)

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Article Chemistry, Multidisciplinary

Biopharmaceutical profiling of sesamol: physiochemical characterization, gastrointestinal permeability and pharmacokinetic evaluation

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RSC ADVANCES (2015)

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Quercetin delivery to porcine cornea and sclera by solid lipid nanoparticles and nanoemulsion

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RSC ADVANCES (2015)

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Article Pharmacology & Pharmacy

Development, characterization and nasal delivery of rosmarinic acid-loaded solid lipid nanoparticles for the effective management of Huntington's disease

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DRUG DELIVERY (2015)

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Article Pharmacology & Pharmacy

Sesamol-loaded solid lipid nanoparticles for treatment of skin cancer

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JOURNAL OF DRUG TARGETING (2015)

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QUERCETIN LOADED NANOSTRUCTURED LIPID CARRIER FOR FOOD FORTIFICATION: PREPARATION, CHARACTERIZATION AND IN VITRO STUDY

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Article Pharmacology & Pharmacy

Vitamin B12-loaded solid lipid nanoparticles as a drug carrier in cancer therapy

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PHARMACEUTICAL DEVELOPMENT AND TECHNOLOGY (2015)

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Article Chemistry, Multidisciplinary

Characterization of solid lipid nanoparticles produced with carnauba wax for rosmarinic acid oral delivery

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RSC ADVANCES (2015)

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Article Pharmacology & Pharmacy

Mixed Polyethylene Glycol-Modified Breviscapine-Loaded Solid Lipid Nanoparticles for Improved Brain Bioavailability: Preparation, Characterization, and In Vivo Cerebral Microdialysis Evaluation in Adult Sprague Dawley Rats

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AAPS PHARMSCITECH (2014)

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Optimization of the production of solid Witepsol nanoparticles loaded with rosmarinic acid

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COLLOIDS AND SURFACES B-BIOINTERFACES (2014)

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Characterization and biodistribution in vivo of quercetin-loaded cationic nanostructured lipid carriers

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COLLOIDS AND SURFACES B-BIOINTERFACES (2014)

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Preparation and characterization of ascorbic acid loaded solid lipid nanoparticles and investigation of their apoptotic effects

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COLLOIDS AND SURFACES B-BIOINTERFACES (2014)

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Article Biophysics

Physicochemical characterization of epigallocatechin gallate lipid nanoparticles (EGCG-LNs) for ocular instillation

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COLLOIDS AND SURFACES B-BIOINTERFACES (2014)

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Article Food Science & Technology

Solid lipid nanoparticles enhance oral bioavailability of resveratrol, a natural polyphenol

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FOOD RESEARCH INTERNATIONAL (2014)

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Article Agriculture, Multidisciplinary

Cellular Uptake of β-Carotene from Protein Stabilized Solid Lipid Nanoparticles Prepared by Homogenization-Evaporation Method

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JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2014)

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Luteolin-loaded solid lipid nanoparticles synthesis, characterization, & improvement of bioavailability, pharmacokinetics in vitro and vivo studies

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JOURNAL OF NANOPARTICLE RESEARCH (2014)

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Article Biotechnology & Applied Microbiology

Targeting of eugenol-loaded solid lipid nanoparticles to the epidermal layer of human skin

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NANOMEDICINE (2014)

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Article Medicine, Research & Experimental

Baicalin protects the myocardium from reperfusion-induced damage in isolated rat hearts via the antioxidant and paracrine effect

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EXPERIMENTAL AND THERAPEUTIC MEDICINE (2014)

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Article Ophthalmology

Novel Lutein Loaded Lipid Nanoparticles on Porcine Corneal Distribution

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JOURNAL OF OPHTHALMOLOGY (2014)

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Curcumin-loaded solid lipid nanoparticles have prolonged in vitro antitumour activity, cellular uptake and improved in vivo bioavailability

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COLLOIDS AND SURFACES B-BIOINTERFACES (2013)

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Article Pharmacology & Pharmacy

Pharmacological management of ocular hypertension: current approaches and future prospective

Claudio Bucolo et al.

CURRENT OPINION IN PHARMACOLOGY (2013)

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Article Pharmacology & Pharmacy

Curcumin loaded solid lipid nanoparticles: An efficient formulation approach for cerebral ischemic reperfusion injury in rats

Vandita Kakkar et al.

EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS (2013)

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Article Food Science & Technology

Hesperetin-Loaded Solid Lipid Nanoparticles and Nanostructure Lipid Carriers for Food Fortification: Preparation, Characterization, and Modeling

Milad Fathi et al.

FOOD AND BIOPROCESS TECHNOLOGY (2013)

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Article Chemistry, Applied

Formation of solid shell nanoparticles with liquid ω-3 fatty acid core

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FOOD CHEMISTRY (2013)

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Article Nanoscience & Nanotechnology

Thymoquinone-loaded nanostructured lipid carriers: preparation, gastroprotection, in vitro toxicity, and pharmacokinetic properties after extravascular administration

Siddig Ibrahim Abdelwahab et al.

INTERNATIONAL JOURNAL OF NANOMEDICINE (2013)

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Article Pharmacology & Pharmacy

Ultra-small NLC for improved dermal delivery of coenyzme Q10

Julia C. Schwarz et al.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2013)

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Article Materials Science, Biomaterials

The formulation and delivery of curcumin with solid lipid nanoparticles for the treatment of on non-small cell lung cancer both in vitro and in vivo

Ping Wang et al.

MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS (2013)

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Article Multidisciplinary Sciences

Risk Factors for Poor Treatment Outcomes in Patients with MDR-TB and XDR-TB in China: Retrospective Multi-Center Investigation

Shenjie Tang et al.

PLOS ONE (2013)

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Article Food Science & Technology

Lipid nanoparticles based on omega-3 fatty acids as effective carriers for lutein delivery. Preparation and in vitro characterization studies

Ioana Lacatusu et al.

JOURNAL OF FUNCTIONAL FOODS (2013)

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Article Biotechnology & Applied Microbiology

Antioxidant, Lipid Lowering, and Membrane Stabilization Effect of Sesamol against Doxorubicin-Induced Cardiomyopathy in Experimental Rats

Anusha Chennuru et al.

BIOMED RESEARCH INTERNATIONAL (2013)

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Article Critical Care Medicine

Formulation and characterization of solid lipid nanoparticles loaded Neem oil for topical treatment of acne

V. Vijayan et al.

JOURNAL OF ACUTE DISEASE (2013)

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Article Biology

Horizontally transferred fungal carotenoid genes in the two-spotted spider mite Tetranychus urticae

Boran Altincicek et al.

BIOLOGY LETTERS (2012)

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Article Pharmacology & Pharmacy

Curcumin loaded NLC induces histone hypoacetylation in the CNS after intraperitoneal administration in mice

Carmelo Puglia et al.

EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS (2012)

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Article Pharmacology & Pharmacy

Nanoparticulate lipid dispersions for bromocriptine delivery: Characterization and in vivo study

Elisabetta Esposito et al.

EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS (2012)

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Article Pharmacology & Pharmacy

Development of a new delivery system consisting in drug - in cyclodextrin - in nanostructured lipid carriers for ketoprofen topical delivery

M. Cirri et al.

EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS (2012)

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Article Oncology

Chemoprevention of pancreatic cancer using solid-lipid nanoparticulate delivery of a novel aspirin, curcumin and sulforaphane drug combination regimen

Dhruvitkumar Sutaria et al.

INTERNATIONAL JOURNAL OF ONCOLOGY (2012)

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Article Pharmacology & Pharmacy

Emodin loaded solid lipid nanoparticles: Preparation, characterization and antitumor activity studies

Shengpeng Wang et al.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2012)

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Article Pharmacology & Pharmacy

Development of a Quercetin-loaded nanostructured lipid carrier formulation for topical delivery

Guo Chen-yu et al.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2012)

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Review Chemistry, Multidisciplinary

Administration of resveratrol: What formulation solutions to bioavailability limitations?

A. Amri et al.

JOURNAL OF CONTROLLED RELEASE (2012)

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Article Food Science & Technology

Characterization of Ergocalciferol Loaded Solid Lipid Nanoparticles

Mandar R. Patel et al.

JOURNAL OF FOOD SCIENCE (2012)

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Article Medicine, Research & Experimental

Enhanced Apoptotic Effect of Curcumin Loaded Solid Lipid Nanoparticles

Kakkar Vandita et al.

MOLECULAR PHARMACEUTICS (2012)

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Article Nanoscience & Nanotechnology

Novel bio-active lipid nanocarriers for the stabilization and sustained release of sitosterol

I. Lacatusu et al.

NANOTECHNOLOGY (2012)

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Article Biochemistry & Molecular Biology

The binding of resveratrol to monomer and fibril amyloid beta

Jin-Fang Ge et al.

NEUROCHEMISTRY INTERNATIONAL (2012)

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Proceedings Paper Materials Science, Multidisciplinary

Preparation of Zingiber Officinale Extract Loaded Solid Lipid Nanoparticles

N. Ratcharin et al.

BIOMATERIALS AND APPLICATIONS (2012)

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Article Biophysics

Enhancement in antifungal activity of eugenol in immunosuppressed rats through lipid nanocarriers

A. Garg et al.

COLLOIDS AND SURFACES B-BIOINTERFACES (2011)

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Article Food Science & Technology

Evaluating potential of curcumin loaded solid lipid nanoparticles in aluminium induced behavioural, biochemical and histopathological alterations in mice brain

Vandita Kakkar et al.

FOOD AND CHEMICAL TOXICOLOGY (2011)

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Article Pharmacology & Pharmacy

Lipid nanocarriers for dermal delivery of lutein: Preparation, characterization, stability and performance

Khalil Mitri et al.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2011)

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Article Chemistry, Applied

Formulation of curcumin-loaded solid lipid nanoparticles produced by fatty acids coacervation technique

Daniela Chirio et al.

JOURNAL OF MICROENCAPSULATION (2011)

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Article Food Science & Technology

Exploring solid lipid nanoparticles to enhance the oral bioavailability of curcumin

Vandita Kakkar et al.

MOLECULAR NUTRITION & FOOD RESEARCH (2011)

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Article Neurosciences

Removal of melatonin receptor type 1 increases intraocular pressure and retinal ganglion cells death in the mouse

Susana Alcantara-Contreras et al.

NEUROSCIENCE LETTERS (2011)

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Article Geriatrics & Gerontology

Delivery of Sesamol-Loaded Solid Lipid Nanoparticles to the Brain for Menopause-Related Emotional and Cognitive Central Nervous System Derangements

Vandita Kakkar et al.

REJUVENATION RESEARCH (2011)

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Article Nutrition & Dietetics

Dose effects of dietary phytosterols on cholesterol metabolism: a controlled feeding study

Susan B. Racette et al.

AMERICAN JOURNAL OF CLINICAL NUTRITION (2010)

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Article Chemistry, Medicinal

Preparation, Optimization and Characteristic of Huperzine A Loaded Nanostructured Lipid Carriers

Chun-Rong Yang et al.

CHEMICAL & PHARMACEUTICAL BULLETIN (2010)

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Article Chemistry, Medicinal

Preparation and characterization of nanostructured lipid carriers loaded traditional Chinese medicine, zedoary turmeric oil

Xiu-Li Zhao et al.

DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY (2010)

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Article Chemistry, Medicinal

Characterization and formulation optimization of solid lipid nanoparticles in vitamin K1 delivery

Chi-Hsien Liu et al.

DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY (2010)

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Article Pharmacology & Pharmacy

Transferrin mediated solid lipid nanoparticles containing curcumin: Enhanced in vitro anticancer activity by induction of apoptosis

Rohit S. Mulik et al.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2010)

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Article Pharmacology & Pharmacy

Influence of nanostructured lipid carriers (NLC) on the physical properties of the Cutanova Nanorepair Q10 cream and the in vivo skin hydration effect

Jana Pardeike et al.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2010)

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Review Food Science & Technology

Bioavailability and Delivery of Nutraceuticals Using Nanotechnology

Qingrong Huang et al.

JOURNAL OF FOOD SCIENCE (2010)

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Article Chemistry, Multidisciplinary

Antioxidant Capacity of Lipid Nanoparticles Loaded with Rosemary Extract

I. Lacatusu et al.

MOLECULAR CRYSTALS AND LIQUID CRYSTALS (2010)

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Article Pharmacology & Pharmacy

Hesperidin Gastroresistant Microparticles by Spray-Drying: Preparation, Characterization, and Dissolution Profiles

Francesca Sansone et al.

AAPS PHARMSCITECH (2009)

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Review Chemistry, Physical

Characterization and potential applications of nanostructured aqueous dispersions

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ADVANCES IN COLLOID AND INTERFACE SCIENCE (2009)

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Effect of Omega-3 Fatty Acids on Crystallization, Polymorphic Transformation and Stability of Tripalmitin Solid Lipid Nanoparticle Suspensions

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CRYSTAL GROWTH & DESIGN (2009)

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Review Biochemistry & Molecular Biology

Potential therapeutic effects of curcumin, the anti-inflammatory agent, against neurodegenerative, cardiovascular, pulmonary, metabolic, autoimmune and neoplastic diseases

Bharat B. Aggarwal et al.

INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY (2009)

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Article Agriculture, Multidisciplinary

Impact of Surfactant Properties on Oxidative Stability of β-Carotene Encapsulated within Solid Lipid Nanoparticles

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JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2009)

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Article Chemistry, Multidisciplinary

Enhancement of gastrointestinal absorption of quercetin by solid lipid nanoparticles

HouLi Li et al.

JOURNAL OF CONTROLLED RELEASE (2009)

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Article Endocrinology & Metabolism

Melatonin delivery in solid lipid nanoparticles: prevention of cyclosporine A induced cardiac damage

Rita Rezzani et al.

JOURNAL OF PINEAL RESEARCH (2009)

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Article Food Science & Technology

Elimination and metabolism of sesamol, a bioactive compound in sesame oil, in rats

Kuo-Ching Jan et al.

MOLECULAR NUTRITION & FOOD RESEARCH (2009)

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Article Biochemistry & Molecular Biology

Neuroprotective Effect of Baicalin in a Rat Model of Permanent Focal Cerebral Ischemia

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NEUROCHEMICAL RESEARCH (2009)

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Article Chemistry, Medicinal

Sesamol: An Efficient Antioxidant with Potential Therapeutic Benefits

Thiraviam Geetha et al.

MEDICINAL CHEMISTRY (2009)

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Article Neurosciences

Administration of sesamol improved blood-brain barrier function in streptozotocin-induced diabetic rats

R. L. VanGilder et al.

EXPERIMENTAL BRAIN RESEARCH (2009)

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Article Biochemistry & Molecular Biology

Reactive oxygen and reactive nitrogen as signaling molecules for caspase 3 activation in acute cardiac transplant rejection

Galen M. Pieper et al.

ANTIOXIDANTS & REDOX SIGNALING (2008)

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Review Pharmacology & Pharmacy

Melatonin receptors, heterodimerization, signal transduction and binding sites: what's new?

R. Jockers et al.

BRITISH JOURNAL OF PHARMACOLOGY (2008)

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Article Oncology

New derivatives of vitamin B12 show preferential targeting of tumors

Robert Waibel et al.

CANCER RESEARCH (2008)

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Article Food Science & Technology

β-Carotene-loaded nanostructured Lipid carriers

A. Hentschel et al.

JOURNAL OF FOOD SCIENCE (2008)

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Review Biochemistry & Molecular Biology

Foods and liver health

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MOLECULAR ASPECTS OF MEDICINE (2008)

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Micellarisation of carotenoids from raw and cooked vegetables

L. Ryan et al.

PLANT FOODS FOR HUMAN NUTRITION (2008)

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Review Ophthalmology

Circadian rhythms in the eye: The physiological significance of melatonin receptors in ocular tissues

Allan F. Wiechmann et al.

PROGRESS IN RETINAL AND EYE RESEARCH (2008)

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Article Pediatrics

Incidence of late vitamin K deficiency bleeding in newborns in the Netherlands in 2005: evaluation of the current guideline

Marloes M. IJland et al.

EUROPEAN JOURNAL OF PEDIATRICS (2008)

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Article Endocrinology & Metabolism

A randomized, placebo-controlled trial of controlled release melatonin treatment of delayed sleep phase syndrome and impaired sleep maintenance in children with neurodevelopmental disabilities

Michael B. Wasdell et al.

JOURNAL OF PINEAL RESEARCH (2008)

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Review Endocrinology & Metabolism

Cardiovascular diseases: protective effects of melatonin

Sandra Tengattini et al.

JOURNAL OF PINEAL RESEARCH (2008)

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Review Dermatology

Photoageing: mechanism, prevention and therapy

M. Yaar et al.

BRITISH JOURNAL OF DERMATOLOGY (2007)

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Article Endocrinology & Metabolism

Melatonin protects against common deletion of mitochondrial DNA-augmented mitochondrial oxidative stress and apoptosis

Mei-Jie Jou et al.

JOURNAL OF PINEAL RESEARCH (2007)

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Article Chemistry, Multidisciplinary

Solid lipid nanoparticles incorporating melatonin as new model for sustained oral and transdermal delivery systems

Lorenzo Priano et al.

JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY (2007)

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Article Medicine, General & Internal

Vitamin D-deficiency rickets among children in Canada

Leanne M. Ward et al.

CANADIAN MEDICAL ASSOCIATION JOURNAL (2007)

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Review Pharmacology & Pharmacy

Lipid nanoparticles for improved topical application of drugs for skin diseases

Monika Schaefer-Korting et al.

ADVANCED DRUG DELIVERY REVIEWS (2007)

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Article Pharmacology & Pharmacy

Formulation and characterization of curcuminoids loaded solid lipid nanoparticles

Waree Tiyaboonchai et al.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2007)

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The antioxidant role of coenzyme Q

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MITOCHONDRION (2007)

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Review Ophthalmology

Melatonin in the eye: Implications for glaucoma

Per O. Lundmark et al.

EXPERIMENTAL EYE RESEARCH (2007)

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Review Medicine, General & Internal

Melatonin: therapeutic and clinical utilization

A. Altun et al.

INTERNATIONAL JOURNAL OF CLINICAL PRACTICE (2007)

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Article Mycology

In vitro activity of eugenol against Candida albicans biofilms

Miao He et al.

MYCOPATHOLOGIA (2007)

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Review Food Science & Technology

Biological properties of onions and garlic

Marta Corzo-Martinez et al.

TRENDS IN FOOD SCIENCE & TECHNOLOGY (2007)

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Article Nanoscience & Nanotechnology

Preparation of oridonin-loaded solid lipid nanoparticles and studies on them in vitro and in vivo

Dianrui Zhang et al.

NANOTECHNOLOGY (2006)

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Article Dermatology

Oxidative stress in the pathogenesis of skin disease

David R. Bickers et al.

JOURNAL OF INVESTIGATIVE DERMATOLOGY (2006)

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Review Chemistry, Multidisciplinary

Role of antioxidants in prophylaxis and therapy: A pharmaceutical perspective

D. Venkat Ratnam et al.

JOURNAL OF CONTROLLED RELEASE (2006)

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Article Biochemistry & Molecular Biology

Preparation and characterization of solid lipid nanoparticles loaded traditional Chinese medicine

Yingchao Li et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2006)

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Article Pharmacology & Pharmacy

Legislation relating to nutraceuticals in the European Union with a particular focus on botanical-sourced products

OP Gulati et al.

TOXICOLOGY (2006)

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Article Pharmacology & Pharmacy

Artemisia arborescens L essential oil-loaded solid lipid nanoparticles for potential agricultural application: Preparation and characterization

F Lai et al.

AAPS PHARMSCITECH (2006)

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Review Biochemistry & Molecular Biology

Lycopene-rich products and dietary photoprotection

W Stahl et al.

PHOTOCHEMICAL & PHOTOBIOLOGICAL SCIENCES (2006)

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Article Public, Environmental & Occupational Health

A quantitative analysis of fish consumption and stroke risk

C Bouzan et al.

AMERICAN JOURNAL OF PREVENTIVE MEDICINE (2005)

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Article Agriculture, Multidisciplinary

Sensory-guided decomposition of roasted cocoa nibs (Theobroma cacao) and structure determination of taste-active polyphenols

T Stark et al.

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2005)

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Article Food Science & Technology

Bioactivity and metabolism of trans-resveratrol orally administered to Wistar rats

E Wenzel et al.

MOLECULAR NUTRITION & FOOD RESEARCH (2005)

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Article Pharmacology & Pharmacy

The research on the anti-inflammatory activity and hepatotoxicity of triptolide-loaded solid lipid nanoparticle

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PHARMACOLOGICAL RESEARCH (2005)

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Article Pharmacology & Pharmacy

Inhibitory effects of naringenin on tumor growth in human cancer cell lines and sarcoma S-180-implanted mice

S Kanno et al.

BIOLOGICAL & PHARMACEUTICAL BULLETIN (2005)

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Article Urology & Nephrology

Cellular uptake of vitamin B-12 in patients with chronic renal failure

R Obeid et al.

NEPHRON CLINICAL PRACTICE (2005)

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Review Nutrition & Dietetics

Review of the flavonoids quercetin, hesperetin naringenin. Dietary sources, bioactivities, and epidemiology

I Erlund

NUTRITION RESEARCH (2004)

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Article Biochemistry & Molecular Biology

Curcumin, a novel p300/CREB-binding protein-specific inhibitor of acetyltransferase, represses the acetylation of histone/nonhistone proteins and histone acetyltransferase-dependent chromatin transcription

K Balasubramanyam et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2004)

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Review Hematology

The physiology of vitamin K nutriture and vitamin K-dependent protein function in atherosclerosis

KL Berkner et al.

JOURNAL OF THROMBOSIS AND HAEMOSTASIS (2004)

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Article Pharmacology & Pharmacy

Structurally related antitumor effects of flavanones in vitro and in vivo: involvement of caspase 3 activation, p21 gene expression, and reactive oxygen species production

SC Shen et al.

TOXICOLOGY AND APPLIED PHARMACOLOGY (2004)

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Article Infectious Diseases

Evaluation of carvacrol and eugenol as prophylaxis and treatment of vaginal candidiasis in an immunosuppressed rat model

F Chami et al.

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY (2004)

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Article Chemistry, Medicinal

Formulation and in vitro evaluation of transdermal patches of melatonin

N Kanikkannan et al.

DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY (2004)

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Article Pharmacology & Pharmacy

Solid lipid nanoparticle and microemulsion for topical delivery of triptolide

ZN Mei et al.

EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS (2003)

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Article Pediatrics

Intestinal absorption of mixed micellar phylloquinone (vitamin K1) is unreliable in infants with conjugated hyperbilirubinaemia:: implications for oral prophylaxis of vitamin K deficiency bleeding

SP Pereira et al.

ARCHIVES OF DISEASE IN CHILDHOOD-FETAL AND NEONATAL EDITION (2003)

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Article Engineering, Chemical

Kinetics of lycopene degradation in tomato puree by heat and light irradiation

J Shi et al.

JOURNAL OF FOOD PROCESS ENGINEERING (2003)

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Article Pharmacology & Pharmacy

α-Tocopherol prevents apoptosis of vascular endothelial cells via a mechanism exceeding that of mere antioxidation

M Uemura et al.

EUROPEAN JOURNAL OF PHARMACOLOGY (2002)

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Article Pharmacology & Pharmacy

Solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC) in cosmetic and dermatological preparations

RH Müller et al.

ADVANCED DRUG DELIVERY REVIEWS (2002)

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Article Medicine, General & Internal

Oral vitamin K lowers the international normalized ratio more rapidly than subcutaneous vitamin K in the treatment of warfarin-associated coagulopathy - A randomized, controlled trial

MA Crowther et al.

ANNALS OF INTERNAL MEDICINE (2002)

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Article Nutrition & Dietetics

Hypovitaminosis D prevalence and determinants among African American and white women of reproductive age: third National Health and Nutrition Examination Survey, 1988-1994

S Nesby-O'Dell et al.

AMERICAN JOURNAL OF CLINICAL NUTRITION (2002)

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Article Biochemistry & Molecular Biology

Protective effect of vitamin E on ultraviolet B light-induced damage in keratinocytes

S Maalouf et al.

MOLECULAR CARCINOGENESIS (2002)

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Article Chemistry, Medicinal

In vitro and in vivo study of two types of long-circulating solid lipid nanoparticles containing paclitaxel

DB Chen et al.

CHEMICAL & PHARMACEUTICAL BULLETIN (2001)

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Review Pharmacology & Pharmacy

Solid lipid nanoparticles (SLN) for controlled drug delivery -: a review of the state of the art

RH Müller et al.

EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS (2000)

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Article Pharmacology & Pharmacy

The absolute bioavailability of oral melatonin

RL DeMuro et al.

JOURNAL OF CLINICAL PHARMACOLOGY (2000)

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Article Pharmacology & Pharmacy

Investigation on the viscoelastic properties of lipid based colloidal drug carriers

A Lippacher et al.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2000)

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Article Pharmacology & Pharmacy

Vitamin A loaded solid lipid nanoparticles for topical use:: occlusive properties and drug targeting to the upper skin

V Jenning et al.

EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS (2000)

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Article Nutrition & Dietetics

Decreased bioavailability of vitamin D in obesity

J Wortsman et al.

AMERICAN JOURNAL OF CLINICAL NUTRITION (2000)

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