Lipid Nanoparticles: An Effective Tool to Improve the Bioavailability of Nutraceuticals

Nano-range bioactive colloidal carrier systems are envisaged to overcome the challenges associated with treatments of numerous diseases. Lipid nanoparticles (LNPs), one of the extensively investigated drug delivery systems, not only improve pharmacokinetic parameters, transportation, and chemical stability of encapsulated compounds but also provide efficient targeting and reduce the risk of toxicity. Over the last decades, nature-derived polyphenols, vitamins, antioxidants, dietary supplements, and herbs have received more attention due to their remarkable biological and pharmacological health and medical benefits. However, their poor aqueous solubility, compromised stability, insufficient absorption, and accelerated elimination impede research in the nutraceutical sector. Owing to the possibilities offered by various LNPs, their ability to accommodate both hydrophilic and hydrophobic molecules and the availability of various preparation methods suitable for sensitive molecules, loading natural fragile molecules into LNPs offers a promising solution. The primary objective of this work is to explore the synergy between nature and nanotechnology, encompassing a wide range of research aimed at encapsulating natural therapeutic molecules within LNPs.

Automated summary

Nano-scale bioactive colloidal carrier systems, such as lipid nanoparticles (LNPs), have shown great potential in overcoming challenges associated with disease treatments. LNPs not only improve the pharmacokinetics and stability of encapsulated compounds, but also provide efficient targeting and reduced toxicity. However, the poor solubility, stability, and absorption of natural therapeutic molecules have hindered research in the nutraceutical sector. Loading these molecules into LNPs offers a promising solution by utilizing their ability to accommodate both hydrophilic and hydrophobic molecules.