期刊
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
卷 24, 期 20, 页码 -出版社
MDPI
DOI: 10.3390/ijms242015395
关键词
flavonoids; cardiotoxicity; doxorubicin; cardioprotection
In this study, the protective effects of 7-hydroxyflavanone (7H), a flavonoid with antioxidative properties, against doxorubicin-induced cardiotoxicity (DIC) were investigated in an in vitro model. The results showed that 7H co-treatment alleviated oxidative stress, improved mitochondrial function, and attenuated apoptosis and necrosis. These findings suggest that 7H could be a potential cardioprotective agent against DIC.
The therapeutic properties of flavonoids are reported to offer cardioprotective benefits against doxorubicin (Dox)-induced cardiotoxicity (DIC). In the current study, we aimed to investigate the prophylactic properties of 7-hydroxyflavanone (7H), a flavonoid with antioxidative properties, against DIC. An in vitro model of DIC was established by exposing H9c2 cardiomyoblasts to Dox for 6 days. Similarly, cells were also co-treated with 7H to assess its ability to mitigate DIC. The data obtained indicate that 7H, as a co-treatment, alleviates Dox-induced oxidative stress by enhancing total glutathione content (p <= 0.001) and superoxide dismutase activity (p <= 0.001) whilst decreasing ROS (p <= 0.001), malondialdehyde production (p <= 0.001) and the secretion of interleukin-6 (p <= 0.001). The data also showed an improvement in mitochondrial function as shown via enhanced bioenergetics, mitochondrial membrane potential, and PGC1-alpha (p <= 0.05) and pAMPK (p <= 0.001) expression. The cardioprotective potential of 7H was further highlighted by its ability attenuate Dox-induced caspase 3/7 activity (p <= 0.001), apoptosis (p <= 0.001) and necrosis (p <= 0.05). In conclusion, our findings demonstrated the cardioprotective benefits of 7H and thus suggests that it could be a suitable candidate cardioprotective agent against DIC.
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