Inflammatory Blood Biomarkers Are Associated with Long-Term Clinical Disease Severity in Parkinson's Disease

Article Neurosciences

Cross-sectional proteomic expression in Parkinson's disease-related proteins in drug-naive patients vs healthy controls with longitudinal clinical follow-up

Ilham Yahya Abdi et al.

Summary: There is a need for reliable and accessible blood-based biomarkers for early diagnosis of Parkinson's disease, which correlate with clinical symptoms and have predictive potential for future clinical trials.

NEUROBIOLOGY OF DISEASE (2023)

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Article Clinical Neurology

Blood Markers of Inflammation, Neurodegeneration, and Cardiovascular Risk in Early Parkinson's Disease

Michael Bartl et al.

Summary: This study assessed established markers of neuronal function, inflammation, and cardiovascular risk in Parkinson's disease (PD) patients. The results showed differential expression of plasma markers in PD, indicating reduced endothelial/atherosclerotic processes, increased thromboembolic risk, and neuroinflammation. Several markers correlated with cognitive decline and motor symptom progression. These findings provide insights into the molecular processes underlying PD and its progression.

MOVEMENT DISORDERS (2023)

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Review Biochemistry & Molecular Biology

The association between inflammatory markers in blood and cerebrospinal fluid: a systematic review and meta-analysis

Frederieke A. J. Gigase et al.

Summary: This systematic review and meta-analysis revealed poor correlation between peripheral and central inflammatory markers in paired blood-CSF samples, with increased correlations in certain study populations.

MOLECULAR PSYCHIATRY (2023)

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Article Neurosciences

Astrocytic VEGFA: An essential mediator in blood-brain-barrier disruption in Parkinson's disease

Guoyu Lan et al.

Summary: This study suggests that oligomeric alpha-synuclein plays a critical role in BBB disruption associated with Parkinson's disease (PD), mediated by astrocyte-derived VEGFA pathway.

GLIA (2022)

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Article Geriatrics & Gerontology

APOE4 Allele, Sex, and Dementia Risk in Parkinson's Disease: Lessons From a Longitudinal Cohort

Chizoba C. Umeh et al.

Summary: The presence of the APOE4 allele in Parkinson's disease patients is associated with a higher risk of subsequent dementia diagnosis and faster progression to dementia, but this relationship is not modified by sex. Those with the APOE4 allele are more likely to have neuropathology associated with Alzheimer's disease.

JOURNAL OF GERIATRIC PSYCHIATRY AND NEUROLOGY (2022)

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Review Biochemistry & Molecular Biology

Biomarker of Neuroinflammation in Parkinson's Disease

Tsai-Wei Liu et al.

Summary: This review summarizes the recent advances in the research on inflammatory biomarkers for Parkinson's disease (PD) detection, as well as monitoring disease progression and treatment response. Neuroinflammation plays a crucial role in the pathogenesis and pathological processes of PD, and various anti-inflammatory medications have demonstrated neuroprotective effects in in vivo or in vitro PD models.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

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Review Neurosciences

Evidence for immune system alterations in peripheral biological fluids in Parkinson?s disease

Michael Bartl et al.

Summary: Immune-related alterations in Parkinson's disease, such as chronic pro-inflammatory status, specific inflammatory pathways, and gut microbiome differences, play a crucial role in the development and progression of PD. In-depth understanding of these inflammatory mechanisms can help design novel immunomodulatory approaches to delay or even stop PD.

NEUROBIOLOGY OF DISEASE (2022)

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Article Clinical Neurology

Association of the inflammation-related proteome with dementia development at older age: results from a large, prospective, population-based cohort study

Kira Trares et al.

Summary: This study found that blood-based inflammation-related proteins are significantly associated with dementia incidence, with CX3CL1, EN-RAGE, LAP TGF-beta-1, and VEGF-A showing the strongest independent associations. Future studies should not only focus on single biomarkers but also on the complex relationships within biomarker clusters.

ALZHEIMERS RESEARCH & THERAPY (2022)

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Article Clinical Neurology

Identification of a possible proteomic biomarker in Parkinson's disease: discovery and replication in blood, brain and cerebrospinal fluid

Laura Winchester et al.

Summary: In this study, a multi-protein panel representative of Parkinson's disease was discovered using multiple cohorts and different measures. The researchers aimed to understand the disease mechanisms through protein expression profiles and find novel biomarkers. The results provide mechanistic insights into the disease and propose a protein signature classifier for further biomarker evaluation.

BRAIN COMMUNICATIONS (2022)

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Review Endocrinology & Metabolism

Regulation of T cell-associated tissues and T cell activation by RANKL-RANK-OPG

Matthew C. Walsh et al.

Summary: The RANKL-RANK-OPG system plays a critical role in T cell biology by regulating T cell tolerance and function through control over thymic development and lymphoid tissue. It influences key functions of the T cell compartment such as cell survival and antigen presentation by regulating the expression of RANKL and RANK on developing T cells and lymphoid tissue cells. Understanding the operation of the RANKL-RANK-OPG system in T cell biology is crucial for immune homeostasis and osteoimmunology.

JOURNAL OF BONE AND MINERAL METABOLISM (2021)

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Letter Clinical Neurology

Early-Onset Parkinson's Disease: A Novel Deletion Comprising the DJ-1 and TNFRSF9 Genes

Suleyman Guler et al.

Summary: A Turkish family was identified with a large deletion in the DJ-1 and TNFRSF9 genes, raising the possibility of TNFRSF9 being a disease modifier in Parkinson's disease patients with DJ-1 mutations.

MOVEMENT DISORDERS (2021)

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Article Geriatrics & Gerontology

Bone-Derived Factors as Potential Biomarkers for Parkinson's Disease

Yuwan Lin et al.

Summary: Plasma levels of OCN and OPN in PD patients are correlated with inflammation response, disease stage, and motor impairment, making them potential biomarkers for PD. The combination of plasma assessment and CSF detection enhances predictive ability for PD.

FRONTIERS IN AGING NEUROSCIENCE (2021)

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Article Biochemistry & Molecular Biology

Pharmacological inhibition of CSF1R by GW2580 reduces microglial proliferation and is protective against neuroinflammation and dopaminergic neurodegeneration

Matthew L. Neal et al.

FASEB JOURNAL (2020)

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Article Neurosciences

CCL23: A Chemokine Associated with Progression from Mild Cognitive Impairment to Alzheimer's Disease

Julia Faura et al.

JOURNAL OF ALZHEIMERS DISEASE (2020)

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Article Clinical Neurology

Plasma cytokine profile in synucleinophaties with dementia

T. S. Usenko et al.

JOURNAL OF CLINICAL NEUROSCIENCE (2020)

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Article Multidisciplinary Sciences

α-Synuclein-specific T cell reactivity is associated with preclinical and early Parkinson's disease

Cecilia S. Lindestam Arlehamn et al.

NATURE COMMUNICATIONS (2020)

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Review Clinical Neurology

Parkinson disease and the immune system - associations, mechanisms and therapeutics

Eng-King Tan et al.

NATURE REVIEWS NEUROLOGY (2020)

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Article Immunology

Identification of CD137-Expressing B Cells in Multiple Sclerosis Which Secrete IL-6 Upon Engagement by CD137 Ligand

Hiu Yi Wong et al.

FRONTIERS IN IMMUNOLOGY (2020)

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Article Clinical Neurology

CD8 T cell nigral infiltration precedes synucleinopathy in early stages of Parkinson's disease

Jordi Galiano-Landeira et al.

BRAIN (2020)

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Article Clinical Neurology

Selected serum cytokines and nitric oxide as potential multi-marker biosignature panels for Parkinson disease of varying durations: a case-control study

Dilini Rathnayake et al.

BMC NEUROLOGY (2019)

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Article Biotechnology & Applied Microbiology

Assessment of the Levels of Level of Biomarkers of Bone Matrix Glycoproteins and Inflammatory Cytokines from Saudi Parkinson Patients

Aziza Alrafiah et al.

BIOMED RESEARCH INTERNATIONAL (2019)

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Article Social Sciences, Interdisciplinary

Confounding and collinearity in regression analysis: a cautionary tale and an alternative procedure, illustrated by studies of British voting behaviour

Ron Johnston et al.

QUALITY & QUANTITY (2018)

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Article Medicine, General & Internal

CCL23: a new CC chemokine involved in human brain damage

A. Simats et al.

JOURNAL OF INTERNAL MEDICINE (2018)

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Review Medicine, Research & Experimental

CXCL9, CXCL10, CXCL11, and their receptor (CXCR3) in neuroinflammation and neurodegeneration

Olga M. Koper et al.

ADVANCES IN CLINICAL AND EXPERIMENTAL MEDICINE (2018)

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Article Clinical Neurology

Inflammatory profile discriminates clinical subtypes in LRRK2-associated Parkinson's disease

K. Brockmann et al.

EUROPEAN JOURNAL OF NEUROLOGY (2017)

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Review Clinical Neurology

Biomarker-Driven Phenotyping in Parkinson's Disease: A Translational Missing Link in Disease-Modifying Clinical Trials

Alberto J. Espay et al.

MOVEMENT DISORDERS (2017)

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Article Multidisciplinary Sciences

T cells from patients with Parkinson's disease recognize α-synuclein peptides

David Sulzer et al.

NATURE (2017)

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Review Clinical Neurology

Cognitive decline in Parkinson disease

Dag Aarsland et al.

NATURE REVIEWS NEUROLOGY (2017)

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Article Geriatrics & Gerontology

NeuroChip, an updated version of the NeuroX genotyping platform to rapidly screen for variants associated with neurological diseases

Cornelis Blauwendraat et al.

NEUROBIOLOGY OF AGING (2017)

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Article Clinical Neurology

Serum immune markers and disease progression in an incident Parkinson's disease cohort (ICICLE-PD)

Caroline H. Williams-Gray et al.

MOVEMENT DISORDERS (2016)

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Article Biochemical Research Methods

The effects of age and gender on plasma levels of 63 cytokines

Anders Larsson et al.

JOURNAL OF IMMUNOLOGICAL METHODS (2015)

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Article Neurosciences

Neuroinflammatory and Amyloidogenic Activities of IL-32 beta in Alzheimer's Disease

Hyung-Mun Yun et al.

MOLECULAR NEUROBIOLOGY (2015)

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Review Neurosciences

Apolipoprotein E in Alzheimer's Disease: An Update

Jin-Tai Yu et al.

ANNUAL REVIEW OF NEUROSCIENCE, VOL 37 (2014)

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Article Geriatrics & Gerontology

Cognitive decline in Parkinson's disease is associated with slowing of resting-state brain activity: a longitudinal study

Kim T. E. Olde Dubbelink et al.

NEUROBIOLOGY OF AGING (2013)

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Article Clinical Neurology

Cerebrospinal fluid and plasma clusterin levels in Parkinson's disease

Karin D. van Dijk et al.

PARKINSONISM & RELATED DISORDERS (2013)

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Article Biochemistry & Molecular Biology

A NETWORK VIEW ON PARKINSON'S DISEASE

Sreedevi Chandrasekaran et al.

COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL (2013)

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Article Immunology

Reduced T helper and B lymphocytes in Parkinson's disease

Claire H. Stevens et al.

JOURNAL OF NEUROIMMUNOLOGY (2012)

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Article Immunology

CD137 ligand activated microglia induces oligodendrocyte apoptosis via reactive oxygen species

Yee Andy Yeo et al.

JOURNAL OF NEUROINFLAMMATION (2012)

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Article Clinical Neurology

Diagnostic criteria for mild cognitive impairment in Parkinson's disease: Movement Disorder Society Task Force guidelines

Irene Litvan et al.

MOVEMENT DISORDERS (2012)

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Article Clinical Neurology

Characterizing Mild Cognitive Impairment in Parkinson's Disease

John C. Dalrymple-Alford et al.

MOVEMENT DISORDERS (2011)

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Review Neurosciences

The Parkinson Progression Marker Initiative (PPMI)

Kenneth Marek et al.

PROGRESS IN NEUROBIOLOGY (2011)

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Review Clinical Neurology

Review: The chemokine receptor CXCR3 and its ligands CXCL9, CXCL10 and CXCL11 in neuroimmunity - a tale of conflict and conundrum

M. Mueller et al.

NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY (2010)

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Article Immunology

Peripheral cytokines profile in Parkinson's disease

M. Reale et al.

BRAIN BEHAVIOR AND IMMUNITY (2009)

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Article Neurosciences

Serum interleukin (IL-2, IL-10, IL-6, IL-4), TNFα, and INFγ concentrations are elevated in patients with atypical and idiopathic parkinsonism

Bogdan Brodacki et al.

NEUROSCIENCE LETTERS (2008)

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Article Cell Biology

Neuroprotective activities of CD4+CD25+ regulatory T cells in an animal model of Parkinson's disease

Ashley D. Reynolds et al.

JOURNAL OF LEUKOCYTE BIOLOGY (2007)

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Article Neurosciences

Expression levels of vascular endothelial growth factor and its receptors in Parkinson's disease

Keiichirou Wada et al.

NEUROREPORT (2006)

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Article Immunology

Impaired accumulation and function of memory CD4 T cells in human IL-12 receptor beta 1 deficiency

AM Cleary et al.

JOURNAL OF IMMUNOLOGY (2003)

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Review Ophthalmology

Macular microcirculation characteristics in Parkinson's disease evaluated by OCT-Angiography: a literature review

Evita Evangelia Christou et al.

Summary: The retina may serve as a predictive factor for neurodegenerative disorders, with recent use of Optical Coherence Tomography Angiography (OCT-A) in studying macular microcirculation changes in Parkinson's disease (PD). While preliminary evidence suggests OCT-A could be a useful biomarker for cerebral vasculature in PD, further research is needed to confirm its predictive value in clinical practice.

SEMINARS IN OPHTHALMOLOGY

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Inflammatory Blood Biomarkers Are Associated with Long-Term Clinical Disease Severity in Parkinson's Disease

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