期刊
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
卷 24, 期 17, 页码 -出版社
MDPI
DOI: 10.3390/ijms241713378
关键词
adenosine A(2A); A(2B) receptors; A(2B) receptor antagonists; anti-aggregation effect; antiplatelet activity; phosphodiesterase activity; lipid peroxidation
The platelet aggregation inhibitory activity of selected xanthine-based adenosine A(2A) and A(2B) receptor antagonists was investigated, and the compounds were found to act as moderately potent non-selective inhibitors of phosphodiesterases (PDEs). The highest inhibitory activity against PDE3A was observed in TB-42, along with moderate activity against PDE2A and PDE5A. The antiplatelet activity of the compounds may be due to inhibition of PDEs, leading to increased cAMP and/or cGMP concentrations in platelets.
The platelet aggregation inhibitory activity of selected xanthine-based adenosine A(2A )and A(2B) receptor antagonists was investigated, and attempts were made to explain the observed effects. The selective A(2B) receptor antagonist PSB-603 and the A(2A) receptor antagonist TB-42 inhibited platelet aggregation induced by collagen or ADP. In addition to adenosine receptor blockade, the compounds were found to act as moderately potent non-selective inhibitors of phosphodiesterases (PDEs). TB-42 showed the highest inhibitory activity against PDE3A along with moderate activity against PDE2A and PDE5A. The antiplatelet activity of PSB-603 and TB-42 may be due to inhibition of PDEs, which induces an increase in cAMP and/or cGMP concentrations in platelets. The xanthine-based adenosine receptor antagonists were found to be non-cytotoxic for platelets. Some of the compounds showed anti-oxidative properties reducing lipid peroxidation. These results may provide a basis for the future development of multi-target xanthine derivatives for the treatment of inflammation and atherosclerosis and the prevention of heart infarction and stroke.
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