期刊
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
卷 24, 期 18, 页码 -出版社
MDPI
DOI: 10.3390/ijms241814375
关键词
Early Growth Response 1; Kruppel-like factor 4; MDA-MB-231 cells; mitogen-activated protein kinase pathway; vasculogenic mimicry
Vasculogenic mimicry (VM) is the phenomenon where cancer cells organize themselves into capillary-like channels. This study investigated the role of Early Growth Response 1 (EGR1) in regulating VM in aggressive cancer cells. The results showed that EGR1 promotes the formation of capillary-like tubes by cancer cells. Furthermore, the study identified the involvement of ERK1/2 and p38 MAPK pathways in regulating the expression of EGR1 and KLF4, highlighting their crucial role in VM.
Vasculogenic mimicry (VM) is an intriguing phenomenon observed in tumor masses, in which cancer cells organize themselves into capillary-like channels that closely resemble the structure and function of blood vessels. Although VM is believed to contribute to alternative tumor vascularization, the detailed regulatory mechanisms controlling these cellular processes remain poorly understood. Our study aimed to investigate the role of Early Growth Response 1 (EGR1) in regulating VM in aggressive cancer cells, specifically MDA-MB-231 triple-negative breast cancer cells. Our study revealed that EGR1 promotes the formation of capillary-like tubes by MDA-MB-231 cells in a 3-dimensional Matrigel matrix. EGR1 was observed to upregulate Kruppel-like factor 4 (KLF4) expression, which regulates the formation of the capillary-like tube structure. Additionally, our findings highlight the involvement of the ERK1/2 and p38 mitogen-activated protein kinase pathways in mediating the expression of EGR1 and KLF4, underscoring their crucial role in VM in MDA-MB-231 cells. Understanding these regulatory mechanisms will provide valuable insights into potential therapeutic targets for preventing VM during the treatment of triple-negative breast cancer.
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