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Article
Chemistry, Multidisciplinary
Raghu Ganugula et al.
Summary: This study evaluated the efficacy of daily oral nanoparticulate-curcumin (nCUR) together with long-acting insulin (INS) to treat diabetic kidney disease (DKD) in a rodent model. Results showed that nCUR+INS or INS can improve diabetes-related abnormalities, while CUR or nCUR alone had less effect. Kidney histopathological results revealed that nCUR and nCUR+INS can mitigate DKD lesions.
JOURNAL OF CONTROLLED RELEASE
(2023)
Review
Integrative & Complementary Medicine
Yuting Sun et al.
Summary: Diabetic kidney disease (DKD) is more common in individuals with diabetes mellitus and often involves oxidative stress. This study aimed to explore the impact of oxidative stress on DKD, conduct a systematic review and meta-analysis, and examine the effects of antioxidants on the disease. Analysis of 19 randomized controlled trials found that antioxidants were effective in reducing albumin excretion rate, urine albumin/creatinine ratio, glycated hemoglobin, and malonaldehyde levels in patients with DKD. These findings suggest that antioxidants may have therapeutic benefits for DKD, particularly in reducing proteinuria and glycated hemoglobin levels. The study offers new insights for drug research and clinical treatment of DKD.
Review
Biochemistry & Molecular Biology
Dimitris Korovesis et al.
Summary: Reactive oxygen species (ROS) play a dual role in physiological conditions, acting as signaling molecules but also causing oxidative stress when accumulated excessively. Ageing and neurodegenerative diseases are associated with oxidative stress and the accumulation of damaged proteins. This review discusses the role of oxidative stress in physiology and pathology, as well as state-of-the-art techniques for detecting and quantifying ROS and oxidized proteins in live cells and in vivo. It also explores the recent research findings on the involvement of oxidative stress in neurological disorders.
Review
Biochemistry & Molecular Biology
Oke-Oghene Philomena Akpoveso et al.
Summary: The global prevalence of diabetes is increasing due to urbanization and an aging population, leading to an increase in diabetic vascular complications. There is a need for safe and effective alternative therapies, with natural products like polyphenols showing potential. Polyphenols can reduce oxidative stress and hyperglycemia, preventing diabetic complications. This review summarizes the effects of polyphenols on endogenous antioxidant systems and discusses therapeutic strategies for diabetic vascular complications.
Review
Medicine, Research & Experimental
Qichao Hu et al.
Summary: Diabetic nephropathy is a severe complication of diabetes, but no effective therapeutic methods other than ACEIs and ARBs have been applied due to its complex pathological mechanisms. Recent studies have shown that emerging therapeutics such as novel target-based pharmacotherapy, cell therapies, and dietary regulation are leading to new hopes for DN management.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Review
Biochemistry & Molecular Biology
Ho-Yin Huang et al.
Summary: Vitamin D is a hormone that participates in various physiological processes. It has been shown to have renoprotective effects by regulating endothelial function, preserving podocytes, modulating the renin-angiotensin-aldosterone system, and exerting anti-inflammatory effects. Current research suggests that vitamin D may delay the onset of diabetic kidney disease. This review summarizes the findings on the role of vitamin D in diabetic kidney disease.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Medicine, Research & Experimental
Sakdithep Chaiyarit et al.
Summary: Recent evidence has shown that mitochondria-derived vesicles (MDVs) play significant roles in the mitochondrial quality control (MQC) system. They are formed to remove dysfunctional mitochondrial components under mild stress conditions, while mitochondrial dynamics and mitophagy are activated to restore mitochondrial structure and functions under severe oxidative stress conditions. MDVs generation serves as a major mechanism for coping with unhealthy mitochondria when other MQC pathways fail. This review summarizes the current understanding of MDVs and discusses their roles in physiological and pathological conditions, with emphasis on their potential clinical relevance in kidney stone disease (KSD) therapeutics and diagnostics.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Review
Nutrition & Dietetics
Omid Asbaghi et al.
Summary: Since a 2014 meta-analysis, several randomized controlled trials have reached inconsistent conclusions on the effect of vitamin E intake on glycemic indices and insulin resistance in adults with diabetes. A new meta-analysis including 38 RCTs with a total of 2171 diabetic patients found that vitamin E intake significantly improved HbA1c and insulin resistance, but had no significant effect on fasting blood glucose. However, short-term interventions with vitamin E showed a significant reduction in fasting blood glucose.
Review
Urology & Nephrology
Xiaoju Ma et al.
Summary: Diabetic kidney disease is a common complication of diabetes and is now the leading cause of end-stage kidney disease. The pathogenesis of diabetic kidney disease is complex, with oxidative stress playing a central role. High glucose levels increase the production of reactive oxygen species, leading to enhanced oxidative stress and activation of various signaling pathways that induce cell apoptosis, inflammation, autophagy, and fibrosis in the kidney, ultimately resulting in kidney injury. Traditional Chinese medicine has unique advantages in preventing and treating diabetic kidney disease due to its multi-target, multi-component, and multi-pathway characteristics. Numerous studies have shown the effectiveness of Chinese herbs and patent medicines in treating diabetic kidney disease. This review provides evidence for the role of oxidative stress in diabetic kidney disease pathogenesis and the benefits of traditional Chinese medicine intervention.
Review
Nutrition & Dietetics
Sulin F. Kamt et al.
Summary: The kidney is a crucial organ functioning in waste elimination and nutrient reabsorption, as well as blood pressure regulation, electrolyte balance, blood pH homeostasis, erythropoiesis, and vitamin D maturation. However, due to its heavy workload and constant exposure to insults, both acute kidney injury (AKI) and chronic kidney disease (CKD) can develop. Unfortunately, there are currently no effective therapeutic managements for AKI or CKD, highlighting the urgent need for novel approaches in treating kidney injury.
Review
Nutrition & Dietetics
Javiera D'andurain et al.
Summary: Advanced chronic kidney disease (CKD) stages lead to increased inflammation and oxidative stress. Renal hemodialysis (HD) is not efficient in controlling inflammation in stage 5 CKD patients. However, regular curcumin consumption has been shown to reduce inflammation and oxidative stress in chronic disease patients, suggesting its potential benefits for HD patients. This review examines the effects of curcumin intake on inflammation and oxidative stress in HD patients, focusing on the mechanisms and consequences of HD and curcumin consumption. While including curcumin as a dietary supplement has shown to control inflammation in HD patients, the optimal dosage and administration method are still uncertain. Further research on curcumin bioaccessibility is needed to design effective oral administration vehicles. This information will contribute to future nutritional interventions that evaluate the efficacy of curcumin supplementation in HD diet therapy.
Article
Nutrition & Dietetics
Yujie Zhong et al.
Summary: Diosgenin (DIO) inhibits ROS production by modulating NOX4 and MRC complexes, suppressing mitochondrial and ER stress-induced apoptosis, thereby attenuating diabetic nephropathy (DN).
Review
Endocrinology & Metabolism
Ziwei Zhang et al.
Summary: Diabetes mellitus (DM) is a metabolic disease characterized by chronic hyperglycemia, with insulin deficiency or resistance as the main cause, leading to damage in various target organs. Oxidative stress, resulting from an imbalance between free radicals production and antioxidant scavenging, is one of the main mechanisms linking DM and its complications. This paper reviews the dysfunction of mitochondria induced by high glucose-induced oxidative stress in the DM model and proposes a new treatment plan based on mitochondrial dysfunction.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Hui-fang Zhang et al.
Summary: This study found that alpha lipoamide (ALM) has a protective effect on the kidneys of type 2 diabetes mellitus mice. It can restore renal function, reduce fibrosis, and improve mitochondrial dysfunction. ALM exerts its protective effects through the regulation of the CDX2/CFTR/beta-catenin signaling pathway.
ACTA PHARMACOLOGICA SINICA
(2023)
Review
Biochemistry & Molecular Biology
Jorge Rico-Fontalvo et al.
Summary: Diabetic kidney disease (DKD) is a common complication of diabetes mellitus (DM) and the leading cause of end-stage kidney disease (ESKD) worldwide. Its development involves hemodynamic, metabolic, and inflammatory factors. Persistent albuminuria along with a decline in glomerular filtration rate (GFR) defines this disease, but novel biomarkers originating from its pathogenesis need to be discussed to aid in diagnosis, follow-up, treatment response, and prognosis.
Review
Biochemistry & Molecular Biology
Tarun Pant et al.
Summary: Metabolic imbalances and persistent hyperglycemia in diabetes mellitus drive the production of reactive oxygen species (ROS), leading to vascular complications. Recent studies show that changes in long non-coding RNA (lncRNA) regulate mitochondrial function in oxidative stress. Mitochondria-targeted antioxidants (MTAs) have emerged as a promising therapeutic option for managing oxidative stress-induced diseases. This review discusses the potential of lncRNA as a diagnostic biomarker and regulator of oxidative stress in diabetes-associated vascular complications, as well as the use of MTAs in animal models and clinical trials.
Review
Biochemistry & Molecular Biology
Shirin Hassanizadeh et al.
Summary: Curcumin, with its antioxidant, anti-inflammatory, and antibacterial properties, has shown potential for improving various disorders. Encapsulating curcumin in nanoparticles may enhance its therapeutic effects. However, the efficacy of nano-curcumin in different aspects of health and disease has not been summarized in a study.
Review
Medicine, Research & Experimental
Samer Mohandes et al.
Summary: Kidney disease is a leading cause of death in diabetes patients, with diabetic kidney disease (DKD) accounting for nearly half of all chronic kidney disease cases. Podocytes and endothelial cells are found to play a crucial role in the development of albuminuria and early kidney disease in diabetes. Hyperglycemia induces cellular stress in the kidney, leading to changes in cellular metabolism and an excessive workload for proximal tubule cells. Later, mitochondrial defects result in increased oxidative stress and activation of inflammatory pathways, causing progressive decline in kidney function and fibrosis. Blocking the renin-angiotensin system or the sodium-glucose cotransporter can protect cells and slow down the decline in kidney function. Newly identified molecular pathways may pave the way for the development of much-needed novel therapeutics.
JOURNAL OF CLINICAL INVESTIGATION
(2023)
Review
Endocrinology & Metabolism
Elena Vakali et al.
Summary: The study found that ALA supplementation reduced 24-hour urine albumin excretion rate, urine albumin mg/l, and urine albumin to creatinine ratio in patients with diabetes. However, the combination of ALA and medication did not have a significant effect on urine albumin excretion rate. When ALA supplementation was examined separately from medication, it had no effect on urine albumin mg/l but significantly decreased urine albumin to creatinine ratio.
CURRENT DIABETES REVIEWS
(2022)
Article
Endocrinology & Metabolism
Hong Sun et al.
Summary: This study provides global, regional, and country-level estimates of diabetes prevalence and health expenditures for 2021 and projections for 2045. The global prevalence of diabetes is increasing and is expected to have the greatest relative increase in middle-income countries. Diabetes-related health expenditures are also projected to rise.
DIABETES RESEARCH AND CLINICAL PRACTICE
(2022)
Review
Chemistry, Analytical
Sema Demirci-Cekic et al.
Summary: Reactive oxygen and nitrogen species produced during normal metabolism in the human body play important roles in signal transmission and the immune system, but an imbalance between oxidants and antioxidants can lead to oxidative stress and diseases. Maintaining a balanced antioxidant defense system is crucial for overall health and disease prevention.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2022)
Article
Medicine, Research & Experimental
Samar A. Antar et al.
Summary: This study found that telmisartan has a protective effect on renal damage in diabetic rats, reducing hyperglycemia, oxidative stress, inflammation, apoptosis, and angiogenesis. It achieves this protective effect by upregulating the Nrf2/HO-1 signaling pathway.
Article
Cell Biology
Helmut Sies et al.
Summary: This article discusses the key issues associated with identifying the physiological roles of oxidants, with a focus on H2O2 and O-2(.-). The article emphasizes the need for more precise measurement of oxidants and specific identification of their signaling targets. It also highlights the importance of inter-organellar communication and the contribution of environmental exposures. Development of tools for real-time detection and quantification of individual oxidants is crucial for achieving these goals.
NATURE REVIEWS MOLECULAR CELL BIOLOGY
(2022)
Article
Multidisciplinary Sciences
Chao-Chung Ho et al.
Summary: This study evaluated the renal-protective effects of pioglitazone in diabetic kidney disease patients. The results showed that pioglitazone did not reduce the risk of renal disease progression in these patients. Further randomized controlled studies are needed to establish the effects of pioglitazone definitively.
Review
Biotechnology & Applied Microbiology
Cristina Quispe et al.
Summary: Research shows that nanocurcumin has anti-diabetic activity by reducing hyperglycemia through complex pharmacological mechanisms. Therefore, nanocurcumin may be a potential agent in the pharmacotherapeutic management of patients with diabetes.
BIOMED RESEARCH INTERNATIONAL
(2022)
Review
Biochemistry & Molecular Biology
Marziyeh Salami et al.
Summary: This review focuses on the role of resveratrol in diabetic nephropathy (DN) by regulating various signaling pathways involved in reactive oxygen species production, inflammatory processes, autophagy, and mitochondrial dysfunction. Resveratrol has been shown to prevent kidney damage caused by oxidative stress, enhance antioxidant capacity, and attenuate inflammatory and fibrotic responses.
CURRENT MOLECULAR PHARMACOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Marie Ito et al.
Summary: Mitochondrial dysfunction plays a significant role in the development and progression of diabetic kidney disease (DKD), involving oxidative phosphorylation, mitochondrial reactive oxygen species, biogenesis, fission and fusion, mitophagy, and urinary mitochondrial biomarkers. This review summarizes the glucose-induced and non-glucose-induced mitochondrial dysfunction, as well as the impact of different pathways on DKD.
Article
Medicine, Research & Experimental
George J. Dugbartey et al.
Summary: The study found that ALA supplementation can prevent the early development and progression of DN, exerting anti-hyperglycemic, antioxidant, anti-inflammatory, anti-fibrotic, and anti-apoptotic effects.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Medicine, Research & Experimental
N. Semenova et al.
Summary: This study found that SOD activity in moderate COVID-19 patients is influenced by age and gender. Patients aged 18-35 showed higher SOD activity, especially in women. These findings are important for guiding treatment strategies.
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE
(2022)
Review
Biochemistry & Molecular Biology
Mateus P. Mori et al.
Summary: Oxygen in cells has a dual nature, serving both as an energy source and a potential source of damage through reactive oxygen species. The mechanisms for handling oxygen have evolved to maintain cellular homeostasis, with protection as a fundamental principle. Understanding these basic mechanisms is important for disease pathogenesis and maintaining health.
Review
Food Science & Technology
Zaida Zainal et al.
Summary: Tocotrienols (T3s), a type of vitamin E, have anti-inflammatory and antioxidant properties, and can be used for the prevention and treatment of various inflammatory disorders. They also show neuroprotective, anticancer, and anti-osteoporosis effects.
FOOD RESEARCH INTERNATIONAL
(2022)
Review
Biochemistry & Molecular Biology
Patricia C. Braga et al.
Summary: This article discusses the role of interstitial fibroblasts in maintaining kidney architecture and their involvement in chronic kidney diseases (CKD). It also explores the potential of antioxidant targeted therapies and pharmacologic agents in delaying the progression of kidney disease. Furthermore, it highlights the importance of mitochondrial integrity in early detection of CKD.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Mieke Steenbeke et al.
Summary: Patients with chronic kidney disease (CKD) are more prone to oxidative stress and chronic inflammation, resulting in increased production and decreased clearance of advanced glycation end products (AGEs). AGEs may contribute to decreased kidney function and increased all-cause mortality in CKD patients. Interaction between AGEs and their cell-bound receptor RAGE activates nuclear factor kappa-B (NF-kappa B), leading to cell dysfunction and increased production of inflammatory cytokines. Alterations in the AGE-RAGE system are associated with the development of various chronic kidney diseases. Soluble RAGE (sRAGE) acts as a decoy receptor to inhibit membrane-bound RAGE activation and AGE-RAGE-related toxicity. The ratio of AGEs to sRAGE may be a useful tool for predicting the prognosis of kidney diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Nutrition & Dietetics
Mateus de Lima Macena et al.
Summary: This study assessed the effects of dietary polyphenols on adults with diabetic nephropathy. The results showed significant improvements in glycemic control, renal function, and oxidative stress markers with polyphenol intervention. However, the study quality was low and there was heterogeneity in the types and doses of interventions used.
Review
Endocrinology & Metabolism
Chan-Young Jung et al.
Summary: Diabetic kidney disease (DKD) is the leading cause of end-stage kidney disease, but its prevalence has not declined in the past 30 years. Extensive research has been conducted to improve the prediction of DKD onset and progression, including the search for novel biomarkers and the use of high-throughput omic approaches.
DIABETES & METABOLISM JOURNAL
(2022)
Review
Biochemistry & Molecular Biology
Yu-Ting Zhu et al.
Summary: Podocytopathies are kidney diseases driven by podocyte injury. This review highlights the crucial role of mitochondrial oxidative stress in the pathogenesis of podocytopathies and its relationship with cell death in podocytes. Exogenous antioxidants can protect podocytes from damage. The review aims to identify new targets for improving the treatment of podocytopathies.
Review
Biochemistry & Molecular Biology
Francesco Galli et al.
Summary: Vitamin E is an essential nutrient and antioxidant that plays a role in protecting tissues and regulating gene expression and lipid metabolism. Chronic kidney disease can affect the metabolism and function of vitamin E, but vitamin E therapy shows promising results in preventing cardiovascular disease and complications related to immune and hematological processes.
Review
Biochemistry & Molecular Biology
Meiming Su et al.
Summary: Diabetes mellitus (DM) is a common chronic disease with significant complications. Resveratrol, a plant-derived compound, has shown protective effects against diabetes and its cardiovascular complications. These effects are mediated through various signaling pathways.
Article
Multidisciplinary Sciences
Sadaf Anwar et al.
Summary: The study aimed to test the efficacy of an oil blend against diabetic nephropathy. The findings suggest that the oil blend can reduce renal injury, preserve renal architecture, and exhibit potential antidiabetic and antioxidant capabilities.
JOURNAL OF KING SAUD UNIVERSITY SCIENCE
(2022)
Review
Pharmacology & Pharmacy
Yulia Pastukhova et al.
Summary: This review examines the important evidence of vitamin D as a potential method of prevention for obesity, type 2 diabetes, and diabetic nephropathy. The findings suggest that vitamin D improves renal function in diabetic nephropathy by inhibiting the renin-angiotensin-aldosterone system and has anti-inflammatory, antiproliferative, and anti-metastatic effects that improve endothelial function.
REVIEWS ON RECENT CLINICAL TRIALS
(2022)
Article
Endocrinology & Metabolism
Marina A. Da Renskaya et al.
Summary: In men with type 1 diabetes, regardless of the albuminuria level, there are higher levels of oxidative damage to lipids and DNA. These parameters are closely related to the duration of the disease.
Article
Medicine, Research & Experimental
Marina A. Darenskaya et al.
Summary: The aim of this research was to evaluate the level of integral oxidative stress index (OSI) in Asian boys and girls with exogenous-constitutional obesity. The study found significant increases in lipid peroxidation products and decreases in antioxidant defense parameters in the obese groups compared to controls. These results emphasize the importance of assessing oxidative stress in exogenous-constitutional obesity.
INTERNATIONAL JOURNAL OF BIOMEDICINE
(2022)
Article
L.D. Denova et al.
Editorial Material
Biochemistry & Molecular Biology
Alessia Remigante et al.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Marina Darenskaya et al.
Summary: This study aimed to assess oxidative damage and antioxidant defense system in men with T1DM in the early stages of diabetic nephropathy. The results showed increased oxidative damage to cellular structures and compromised antioxidant defense system in the early stages of DN. ROC analysis identified parameters with the highest diagnostic significance for different stages of diabetic nephropathy.
Article
Medical Laboratory Technology
Dae-Yeon Lee et al.
Summary: This study explored the role of lactate dehydrogenase A (LDHA)-mediated lactate generation in renal fibrosis and dysfunction in diabetic kidney disease (DKD). The researchers found a strong negative correlation between lactate metabolism measures and DKD progression measures in patients with DKD. Experiments with rat models and renal mesangial cells confirmed these findings and suggested that hypoxia-mediated lactic acidosis is involved in the pathogenesis of DKD.
TRANSLATIONAL RESEARCH
(2022)
Article
Nutrition & Dietetics
Douglas Ikedo Machado et al.
Summary: Chronic kidney disease (CKD) and acute kidney injury (AKI) are global health problems that affect over 850 million people. Diabetes mellitus (DM) increases the susceptibility to AKI. Curcumin has shown positive effects in diabetic rats with AKI, improving renal function and reducing oxidative stress.
Review
Nutrition & Dietetics
Amelia K. Fotheringham et al.
Summary: Since the 1980s, the incidence of chronic kidney disease (CKD) has increased by almost 25%. This is partly due to changes in lifestyle and the global consumption of a western diet, which is high in energy, low in fruits and vegetables, and rich in animal protein and processed foods. These dietary trends have led to an increase in the consumption of advanced glycation end products (AGEs) and metabolic disorders, obesity, and diabetes, which contribute to the production of endogenous AGEs in the body. Excessive accumulation of AGEs can be pathologic through receptor-mediated and non-receptor-mediated pathways. AGEs are cleared by the kidneys, making them particularly susceptible to AGE-mediated damage, and high levels of circulating AGEs are associated with an increased risk of CKD and all-cause mortality. Individuals with significant loss of renal function have increased AGE burden, particularly in those with uremia, and there is evidence that lowering AGEs through diet or pharmacological inhibition may be beneficial for CKD. This review explores the pathways of AGE formation and regulation in the body, the impact of diet on endogenous AGE production and dietary AGE consumption, the contribution of AGEs to kidney disease, and the potential of AGE-targeted therapies for kidney disease.
Review
Biochemistry & Molecular Biology
Miguel Fontecha-Barriuso et al.
Summary: Acute kidney injury (AKI) and chronic kidney disease (CKD) are interconnected conditions, and mitochondrial dysfunction and oxidative stress play important roles in the progression of both diseases. New therapeutic approaches targeting mitochondria are needed, but there are barriers to clinical development, such as the lack of diagnostic tests for renal mitochondrial dysfunction.
Review
Biology
Maria Chiara Pelle et al.
Summary: Diabetes is a leading cause of kidney disease, specifically diabetic kidney disease (DKD) which is associated with increased cardiovascular risk. Chronic hyperglycemia and high blood pressure are risk factors for DKD, but blockade of the renin-angiotensin-aldosterone system can improve glomerular function and cardiovascular risk. New antidiabetic drugs have shown promise in delaying kidney disease progression and improving cardiovascular outcomes.
Article
Medicine, General & Internal
M. A. Darenskaya et al.
Summary: The study found that regardless of the level of albuminuria, men with T1DM had significantly elevated levels of podocalyxin, lipid metabolism parameters, and methylglyoxal, with strong relationships between these parameters. These findings can potentially inform the development of strategies for preventing and treating diabetic nephropathy.
BYULLETEN SIBIRSKOY MEDITSINY
(2022)
Review
Medicine, Research & Experimental
Xiaoyu Zhu et al.
Summary: Diabetic nephropathy is a leading cause of end-stage renal disease, causing significant burden on patients and society. Curcumin, a polyphenol curcuminoid, has been shown to have anti-inflammatory, antioxidative, anti-apoptotic, and anti-fibrosis properties, which are beneficial for diabetic nephropathy. Understanding the pharmacological effects of curcumin on diabetic nephropathy may lead to the development of new therapies.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Review
Chemistry, Medicinal
Seigmund Wai Tsuen Lai et al.
Summary: MG and MG-AGEs, produced during metabolism, are associated with the onset and progression of various pathologies. Regulating MG and MG-AGEs may be a potential strategy for preventing diseases and using them as biomarkers for predicting disease risk and early intervention. This review provides an overview of recent advances and knowledge surrounding MG and discusses its clinical applications and therapeutic strategies to improve patient outcomes.
CHEMICAL RESEARCH IN TOXICOLOGY
(2022)
Review
Nutrition & Dietetics
Torsak Tippairote et al.
Summary: Coenzyme Q(10) (CoQ(10)) plays a crucial role in mitochondrial bioenergetics and membrane antioxidant protection. Low circulating levels of CoQ(10) are associated with specific medical conditions. Previous studies on oral CoQ(10) supplementation have shown inconsistent outcomes. Supplementation trials in elders have reported favorable outcomes, but single interventions were less promising in patients with worsening metabolic statuses and multiple nutrient insufficiencies. Mixed CoQ(10) supplementation with other nutrients showed more promising impacts in hosts with compromised nutrient reserves. However, both single and combined interventions were less promising in conditions with established damage. The decision to take supplementation varied based on individuals' metabolic status and nutrient reserves.
Review
Biochemistry & Molecular Biology
Daniela Maria Tanase et al.
Summary: Diabetes mellitus is a debilitating chronic disease with increasing prevalence worldwide. Diabetic Kidney Disease is a major complication of diabetes, caused by mechanisms such as hyperglycemia, inflammation, and oxidative stress. NRF2-inducing strategies show potential in the treatment of Diabetic Kidney Disease, but limitations such as lack of large-scale clinical trials hinder their clinical use.
Article
Nanoscience & Nanotechnology
Lichao Gao et al.
Summary: This study found that curcumin with chitosan nanoparticles improved the activity of podocytes in diabetic nephropathy by alleviating oxidative stress and inflammation, promoting cell proliferation, reducing apoptosis and reducing cell damage.
SCIENCE OF ADVANCED MATERIALS
(2022)
Article
Endocrinology & Metabolism
Michael P. Murphy et al.
Summary: This article discusses the important roles of reactive oxygen species (ROS) in health and disease, and proposes guidelines and best practices for the nomenclature and assessment of ROS, oxidative reactions, and oxidative damage in cells, tissues, and in vivo.
Article
Biotechnology & Applied Microbiology
Aysegul Kapucu
Summary: Crocin has shown potential hypoglycemic and reno-protective effects in type 1 diabetic rats, possibly through modulation of the antioxidant defense system and the MMP-7/PTEN/Akt signaling cascade.
BIOTECHNIC & HISTOCHEMISTRY
(2021)
Review
Biochemistry & Molecular Biology
Bhargav N. Waghela et al.
Summary: NOX family proteins generate ROS as their prime product and play important roles in various cellular functions. Dysregulation of NOX activation leading to enhanced ROS levels is associated with various pathophysiologies, highlighting the importance of maintaining NOX balance for cellular homeostasis.
CELL BIOCHEMISTRY AND FUNCTION
(2021)
Review
Pharmacology & Pharmacy
Chhanda Charan Danta et al.
Summary: This review addresses the pathophysiological mechanisms, new drug targets, and potential therapeutic compounds for DKD. While some positive results have been shown in controlling DKD progression, treatment regimens to reduce mortality in patients with DKD globally have not been well developed. Therefore, the discovery of new therapeutic targets and effective target-based drugs is urgently needed.
EXPERT OPINION ON DRUG DISCOVERY
(2021)
Article
Biochemistry & Molecular Biology
Jozaa Z. ALTamimi et al.
Summary: Curcumin can prevent kidney damage in diabetic rats through a variety of mechanisms, including improvement of renal tubules and mitochondria, reduction of inflammatory cytokines levels, enhancement of mitochondrial function markers, suppression of oxidative stress and apoptosis, among others.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Abdulateef Altuhafi et al.
Summary: This study evaluated the role of glutathione peroxidase in regulating oxidant/antioxidant levels in diabetic patients with nephropathy. The results showed significantly lower GPx activity in diabetic patients, and a negative correlation between total oxidants, lipid peroxidation, and GPx. The findings suggest a relationship between decreased GPx activity and diabetic nephropathy.
REPORTS OF BIOCHEMISTRY AND MOLECULAR BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Mohd Adnan Kausar et al.
Summary: This study examined the nephroprotective efficacy of a polyherbal extract in a diabetic rat model induced by STZ. The results showed that the extract improved glycemic condition, glomerular function, and inflammation and oxidative stress markers. The findings suggest that the polyherbal extract could be a potential pharmaceutical drug for diabetes mellitus, but further long-term studies or clinical trials are needed for validation.
CELLULAR AND MOLECULAR BIOLOGY
(2021)
Review
Urology & Nephrology
Chengyuan Tang et al.
Summary: Mitochondria play crucial roles in eukaryotic cells, and dysfunction can lead to kidney diseases. Protecting mitochondrial homeostasis may prevent and treat kidney injury, representing a potential therapeutic strategy.
NATURE REVIEWS NEPHROLOGY
(2021)
Review
Biochemistry & Molecular Biology
Agata Winiarska et al.
Summary: The incidence of diabetic kidney disease (DKD) in patients with type 2 diabetes is increasing globally. Sodium-glucose cotransporter-2 inhibitors (SGLT2i) and glucagon-like peptide-1 receptor (GLP-1R) agonists have been shown to have nephroprotective effects in patients with established DKD, beyond just improving metabolic control of diabetes. The interactions of these agents with inflammation and oxidative stress appear to have a universal mechanism of organ protection in diabetes and other diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Nutrition & Dietetics
Yan Yi Koay et al.
Summary: The study evaluated the effects of tocotrienol-rich vitamin E supplementation on DKD patients over a 12-month period, showing significant improvements in renal function for patients with stage 3 CKD. The supplementation reduced serum creatinine levels and improved eGFR for these patients, indicating potential renoprotective effects of tocotrienols.
Review
Biochemistry & Molecular Biology
Yu Ah Hong et al.
Summary: Reactive oxygen and nitrogen species play crucial roles in kidney injuries, making antioxidant agents, especially catalytic antioxidants that mimic antioxidant enzymes, effective in combating oxidative stress-related kidney diseases. Research has shown the effectiveness of several catalytic antioxidants in treating disease models associated with oxidative stress.
Review
Biology
Amelia Charlton et al.
Summary: The progressive nature of type 2 diabetes mellitus leads to micro- and macro-vascular complications, including renal and cardiovascular disease, which are major causes of premature morbidity and mortality in diabetic patients. Oxidative stress and inflammation are considered major drivers in the pathogenesis of diabetic complications, and emerging therapies target these crucial pathways to alleviate the burden of the diseases.
Review
Pharmacology & Pharmacy
Shreya R. Savla et al.
Summary: Apocynin is a naturally occurring acetophenone found in the roots of certain plants. Various modifications have been made to enhance its absorption and effectiveness, making it useful for treating a variety of disorders. It primarily acts as an NADPH oxidase inhibitor, but also has off-target effects and diverse mechanisms of action against different diseases.
DRUG METABOLISM REVIEWS
(2021)
Review
Urology & Nephrology
Ralph A. DeFronzo et al.
Summary: Diabetic kidney disease is a leading cause of kidney failure globally, with over 50% of individuals entering dialysis or transplant programmes in the USA affected by it. Hyperglycaemia is the primary factor in its development, leading to various pathophysiological disturbances that contribute to progressive glomerular sclerosis and declining renal function. Multiple agents used in combination are likely to be needed to effectively slow the progression of the disease.
NATURE REVIEWS NEPHROLOGY
(2021)
Review
Endocrinology & Metabolism
Amare Abera Tareke et al.
Summary: The study found that vitamin C supplementation did not significantly impact the lipid profiles of diabetic patients, but could reduce triglyceride levels and other secondary outcomes. Factors such as younger age, longer treatment duration, and higher dose of vitamin C may play a role in the effectiveness of supplementation.
DIABETOLOGY & METABOLIC SYNDROME
(2021)
Article
Chemistry, Medicinal
Arslan Hussain Lodhi et al.
Summary: This study demonstrated the antioxidant potential of H2S and captopril in the treatment of streptozotocin-induced diabetic nephropathy. The results showed that treatment with these compounds improved renal hemodynamics and oxidative stress markers, with a more pronounced effect observed in combined treatment groups.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2021)
Article
Endocrinology & Metabolism
Xiaomeng Feng et al.
Summary: The study found that ferroptosis aggravated diabetic nephropathy and damaged renal tubules in db/db mice through the HIF-1 alpha/HO-1 pathway.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Juan M. Suarez-Rivero et al.
Summary: Coenzyme Q(10) is a key player in mitochondrial function with antioxidant properties, but its analogues with improved characteristics like water solubility and enhanced mitochondrial accumulation may potentially surpass its current role. Recent studies have shown that some of these analogues could outperform CoQ(10) in treating specific diseases.
Article
Endocrinology & Metabolism
So-hyeon Hong et al.
Summary: The study found that vitamin D deficiency is common among Korean T2DM patients, and is associated with microalbuminuria and HDL level, and positively related to diabetic nephropathy.
ENDOCRINOLOGY AND METABOLISM
(2021)
Review
Biochemistry & Molecular Biology
Xia-Qing Wu et al.
Summary: Diabetic kidney disease is a major cause of chronic kidney disease, and controlling blood glucose is effective in preventing it. However, the formation of AGEs related to high glucose plays a central role in the pathogenesis of DKD, causing oxidative stress and inflammation.
FREE RADICAL BIOLOGY AND MEDICINE
(2021)
Review
Genetics & Heredity
Ke-Xue Li et al.
Summary: Phytochemicals, including resveratrol, have emerged as alternative therapies with therapeutic effects on various pathologies, including diabetic kidney disease. Resveratrol has been found to have a broad spectrum of health benefits, particularly in ameliorating chronic or acute kidney injury in the renal system. Further research is needed to overcome limitations, such as poor bioavailability, and improve the efficacy of resveratrol in diabetic nephropathy therapy.
Review
Cell Biology
Amna Ayesha Ahmad et al.
Summary: Diabetic kidney disease (DKD) is the leading cause of end stage renal disease (ESRD) in the USA, with a multifactorial pathogenesis involving activation of multiple signaling pathways that lead to various pathological changes, mainly driven by alterations in mitochondrial bioenergetics. Understanding the role of bioenergetics in the progression of DKD may offer novel therapeutic approaches to delay progression to ESRD.
Article
Endocrinology & Metabolism
Antonio Gonzalez-Perez et al.
Summary: This study aimed to determine the incidence and risk factors for all-cause/CVD mortality and ESRD among people with type 2 diabetes with/without DKD in the UK population. Results showed that individuals with DKD had higher risks of all-cause and CVD mortality, while specific risk factors for ESRD in the DKD cohort included reduced renal function, high material deprivation, cancer, and non-insulin glucose-lowering drugs.
BMJ OPEN DIABETES RESEARCH & CARE
(2021)
Review
Biochemistry & Molecular Biology
Alfredo G. Casanova et al.
Summary: Antioxidant therapy appears to reduce the progression of chronic kidney disease, with pentoxifylline and bardoxolone methyl showing the most robust protection. However, individual variability and potential off-target effects introduce uncertainty regarding the role of oxidative stress in CKD progression and the effectiveness of antioxidant therapy. Personalized antioxidant therapy based on individual factors is necessary for optimal treatment outcomes.
Review
Endocrinology & Metabolism
Sarah Jeffrey et al.
Summary: Alpha-lipoic acid acts as a significant antioxidant in preventing diabetes and complications. Clinical trials have shown positive results in treating diabetic neuropathy, nephropathy, cardiomyopathy, and erectile dysfunction through ALA supplementation. Antioxidants like ALA play a crucial role in treating diabetes-related conditions by inhibiting oxidative stress.
CURRENT DIABETES REVIEWS
(2021)
Article
E. B. Popykhova et al.
Klinichescheskaya Laboratornaya Diagnostika
(2021)
Review
Endocrinology & Metabolism
Tina Okdahl et al.
Summary: Although few randomized controlled trials have shown beneficial efficacy of some dietary supplements on objective primary endpoints and subjective patient-reported outcomes for diabetic neuropathy, there is currently no medical cure and prevention is crucial. Patients are turning to dietary supplements with purported neuroprotective properties, but their effects are often not evidence-based and in need of further scientific testing.
CURRENT DIABETES REPORTS
(2021)
Article
Endocrinology & Metabolism
Carlo Alberto Ricciardi et al.
Summary: Metabolic and haemodynamic perturbations play a key role in the development and progression of diabetic kidney disease (DKD). Controlling metabolic, lipid, and blood pressure levels is crucial in slowing the progression of DKD. Therapies targeting haemodynamic perturbations, such as inhibitors of the renin-angiotensin-aldosterone system (RAAS) and SGLT2 inhibitors, have shown success in the prevention and management of DKD.
METABOLISM-CLINICAL AND EXPERIMENTAL
(2021)
Review
Endocrinology & Metabolism
Fangfang Sun et al.
Summary: The combination of valsartan and alpha-lipoic acid can significantly reduce urinary albumin levels and oxidative stress, increase antioxidant capacity, and alleviate renal function damage in patients with DN.
BMC ENDOCRINE DISORDERS
(2021)
Review
Biotechnology & Applied Microbiology
Nur Samsu
Summary: Diabetic nephropathy is the leading cause of end-stage renal disease worldwide and diagnosis and treatment pose challenges, requiring additional therapeutic interventions. In addition to standard therapy, vitamin D receptor activators, incretin-related drugs, and therapies targeting inflammation may also be promising for preventing the progression of DN.
BIOMED RESEARCH INTERNATIONAL
(2021)
Article
Medicine, Research & Experimental
Marina A. Darenskaya et al.
Summary: In men with type 1 diabetes mellitus, treatment with alpha-lipoic acid led to improvements in lipid metabolism parameters, lipid peroxidation, and antioxidant defense reactions.
AIMS MEDICAL SCIENCE
(2021)
Article
Medicine, Research & Experimental
M. A. Darenskaya et al.
Summary: This study investigated the relationship between carbonyl compounds and components of the glutathione system in young men with type 1 diabetes mellitus at different stages of diabetic nephropathy. The findings showed alterations in levels of certain markers in patients with mild albuminuria.
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE
(2021)
Article
Medicine, General & Internal
Wei-Jing Zhao et al.
Summary: The study found that vitamin D deficiency is independently associated with a higher risk of DPN and DN in T2DM patients, but not DR. Additionally, vitamin D deficiency may serve as a potential predictor for both the occurrence and severity of DPN and DN.
CHINESE MEDICAL JOURNAL
(2021)
Article
Biochemistry & Molecular Biology
Shuangwen Li et al.
Summary: Our research demonstrated the involvement of ferroptosis in the development of DN, and up-regulating Nrf2 with fenofibrate treatment inhibited diabetes-related ferroptosis, delaying the progression of DN. This study provided a new perspective on the development mechanism of DN and offered a new approach to delay the progression of DN.
FREE RADICAL BIOLOGY AND MEDICINE
(2021)
Review
Pharmacology & Pharmacy
Chak Kwong Cheng et al.
BRITISH JOURNAL OF PHARMACOLOGY
(2020)
Article
Endocrinology & Metabolism
Jerine S. Peter et al.
INTERNATIONAL JOURNAL OF DIABETES IN DEVELOPING COUNTRIES
(2020)
Article
Nutrition & Dietetics
Jinxia Chen et al.
JOURNAL OF RENAL NUTRITION
(2020)
Article
Biochemistry & Molecular Biology
Sofia Urner et al.
ANTIOXIDANTS & REDOX SIGNALING
(2020)
Article
Pharmacology & Pharmacy
Jun Wan Shin et al.
BIOCHEMICAL PHARMACOLOGY
(2020)
Review
Biochemistry & Molecular Biology
Kriti Kushwaha et al.
Article
Biotechnology & Applied Microbiology
Elif Kayhan Kustepe et al.
BIOTECHNIC & HISTOCHEMISTRY
(2020)
Article
Integrative & Complementary Medicine
Nasim Pirhadi-Tavandashti et al.
COMPLEMENTARY THERAPIES IN MEDICINE
(2020)
Review
Biochemistry & Molecular Biology
Shara Francesca Rapa et al.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Article
Pharmacology & Pharmacy
Yuxin Xian et al.
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
(2020)
Review
Endocrinology & Metabolism
Didac Mauricio et al.
TRENDS IN ENDOCRINOLOGY AND METABOLISM
(2020)
Review
Medicine, Research & Experimental
Dan-Dan Huang et al.
BIOMEDICINE & PHARMACOTHERAPY
(2020)
Article
Medicine, Research & Experimental
Katarzyna Szkudelska et al.
BIOMEDICINE & PHARMACOTHERAPY
(2020)
Review
Endocrinology & Metabolism
Jonatan Barrera-Chimal et al.
DIABETES OBESITY & METABOLISM
(2020)
Review
Biochemistry & Molecular Biology
Maria Pricci et al.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Article
Agriculture, Multidisciplinary
Hong Xing Zheng et al.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2020)
Review
Biochemistry & Molecular Biology
Sidney J. Stohs et al.
Review
Food Science & Technology
Xiao Meng et al.
Article
Endocrinology & Metabolism
Yinfeng Guo et al.
ACTA DIABETOLOGICA
(2020)
Article
Biochemistry & Molecular Biology
Thangarajeswari Mohan et al.
FREE RADICAL BIOLOGY AND MEDICINE
(2020)
Article
Cell Biology
Gabriella A. Casalena et al.
CELL COMMUNICATION AND SIGNALING
(2020)
Review
Biochemistry & Molecular Biology
Francesca Silvagno et al.
Article
Pharmacology & Pharmacy
Fang Wang et al.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2020)
Review
Nutrition & Dietetics
Vemana Gowd et al.
ADVANCES IN NUTRITION
(2020)
Review
Medicine, Research & Experimental
Prit Kusirisin et al.
JOURNAL OF TRANSLATIONAL MEDICINE
(2020)
Editorial Material
Biochemistry & Molecular Biology
Helmut Sies
Review
Biochemistry & Molecular Biology
Nina Vodosek Hojs et al.
Review
Biochemistry & Molecular Biology
Montserrat Mari et al.
Article
Endocrinology & Metabolism
Nakhoul Nakhoul et al.
JOURNAL OF DIABETES RESEARCH
(2020)
Review
Immunology
Javier Checa et al.
JOURNAL OF INFLAMMATION RESEARCH
(2020)
Article
Toxicology
Mahmoud Hashemzaei et al.
TOXICOLOGY REPORTS
(2020)
Review
Medicine, Research & Experimental
Nutthapoom Pathomthongtaweechai et al.
BIOMEDICINE & PHARMACOTHERAPY
(2020)
Review
Urology & Nephrology
Ya Chen et al.
Article
Endocrinology & Metabolism
A. Sattarinezhad et al.
DIABETES & METABOLISM
(2019)
Article
Biochemistry & Molecular Biology
Salah O. Bashir
ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY
(2019)
Review
Endocrinology & Metabolism
Jessica L. Harding et al.
Article
Cell Biology
Tao Zhang et al.
JOURNAL OF CELLULAR PHYSIOLOGY
(2019)
Review
Cell Biology
Habib Yaribeygi et al.
JOURNAL OF CELLULAR PHYSIOLOGY
(2019)
Review
Endocrinology & Metabolism
Bernadette Thomas
CURRENT DIABETES REPORTS
(2019)
Review
Endocrinology & Metabolism
Anoop Misra et al.
JOURNAL OF DIABETES
(2019)
Article
Environmental Sciences
Xiang Peng et al.
ENVIRONMENTAL TOXICOLOGY
(2019)
Review
Cell Biology
Elisabetta Bigagli et al.
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2019)
Review
Pharmacology & Pharmacy
Annabelle M. Warren et al.
EXPERT OPINION ON THERAPEUTIC TARGETS
(2019)
Review
Medicine, General & Internal
Xiaofeng Zhang et al.
Article
Multidisciplinary Sciences
Xinyu Lin et al.
Article
Fisheries
Hongdan Wang et al.
FISH & SHELLFISH IMMUNOLOGY
(2019)
Review
Cell Biology
Nurbubu T. Moldogazieva et al.
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2019)
Review
Biochemistry & Molecular Biology
Bahare Salehi et al.
Review
Biochemistry & Molecular Biology
Angelo Di Vincenzo et al.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2019)
Article
Medicine, General & Internal
Giovanni Conti et al.
MEDICINA-LITHUANIA
(2019)
Article
Food Science & Technology
Benhong Zhou et al.
FOOD AND CHEMICAL TOXICOLOGY
(2019)
Article
Endocrinology & Metabolism
Jia Sun et al.
JOURNAL OF ENDOCRINOLOGY
(2019)
Article
Food Science & Technology
Huan-Wei Chen et al.
JOURNAL OF FOOD AND DRUG ANALYSIS
(2019)
Review
Endocrinology & Metabolism
Mahaboob Khan Sulaiman
DIABETOLOGY & METABOLIC SYNDROME
(2019)
Article
Endocrinology & Metabolism
Saumik Biswas et al.
FRONTIERS IN ENDOCRINOLOGY
(2019)
Article
Medicine, General & Internal
Melika Fallah et al.
INTERNATIONAL JOURNAL OF PREVENTIVE MEDICINE
(2019)
Article
Endocrinology & Metabolism
Maliheh Barzegari et al.
DIABETES & METABOLIC SYNDROME-CLINICAL RESEARCH & REVIEWS
(2019)
Article
Medicine, General & Internal
Hayder M. Al-Kuraishy et al.
JOURNAL OF LABORATORY PHYSICIANS
(2019)
Review
Physiology
Yangyang Wang et al.
KIDNEY & BLOOD PRESSURE RESEARCH
(2019)
Review
Biochemistry & Molecular Biology
David Mantle et al.
