Association between serum copper level and reproductive health of Women in the United States: a cross-sectional study

Copper is an indispensable trace element in metabolism. This study aimed to investigate the relationship between copper and reproductive health, and possibly provide new insights for diagnosis and treatment. This study was based on data extracted from the NHANES database (2013-2014 and 2015-2016). The t-test, ANOVA, Chi-square test, multiple linear regression, and restricted cubic spline analysis were used. Serum copper levels were significantly higher in women with gestational diabetes than in those without gestational diabetes (P = 0.0150). Women with higher copper levels and smoking habits tended to deliver overweight babies (P = 0.028). Women with diabetes had higher serum copper and were prone to deliver overweight babies (P = 0.024). Serum copper levels showed a positive relationship with sex hormone-binding globulin (SHBG) levels (P < 0.0001). In this study, serum copper levels were found to be associated with reproductive health in women. Further studies are required to draw causal inferences.

Automated summary

Copper is an essential trace element in metabolism, and this study aimed to explore its relationship with reproductive health. The study analyzed data from the NHANES database and found that women with gestational diabetes had higher serum copper levels. Women with higher copper levels and smoking habits were more likely to deliver overweight babies. Serum copper levels were also positively associated with sex hormone-binding globulin (SHBG) levels.