期刊
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
卷 242, 期 -, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.ijbiomac.2023.125118
关键词
Photothermal effect; Silver nanoparticle; Antibacterial activity; Biomedical application; Tannic acid
This study investigates the properties of photothermal and pH-responsive nanocomposite hydrogels containing silver nanoparticles (AgNPs). The results show that AgNPs enhance the antibacterial activities and photothermal conversion ability of the hydrogel. The hydrogel prepared with 200 mM silver nitrate combined with near infrared radiation exhibits the highest antibacterial efficiency and also demonstrates pH-responsive release of tannic acid. The nanocomposite hydrogels show good biocompatibility.
Bacterial wound infections remain a significant health issue of great concern. Hence, there is a need to develop a novel material with antibacterial properties and smart functions. In this study, the effects of silver nanoparticles content (AgNPs) on properties of photothermal and pH-responsive nanocomposite hydrogels were investigated. The nanocomposite hydrogel samples were prepared using cassava starch waste modified by carboxymethylation (CMS), and mixed with poly vinly alcohol (PVA) and tannic acid (TA). The presence of AgNPs in the hydrogel samples enhanced antibacterial activities and photothermal conversion ability. The use of as-prepared hydrogel using 200 mM silver nitrate (H-AgNPs-200) combined with near infrared (NIR) radiation produced 100 % antibacterial efficiency for Escherichia coli (E.coli) and 98.2 % for Staphylococcus aureus (S.aureus). Furthermore, the H-AgNPs-200 also provided the highest storage modulus at 8.78 kPa. The obtained nanocomposite hydrogel was shown to exhibit pH-responsive release of TA. Under NIR radiation, higher release of TA at different pH was observed. The cytotoxicity study indicated that the nanocomposite hydrogels had good biocompatibility. Hence, the development of nanocomposite hydrogel-based CMS from cassava starch waste/PVA/AgNPs is a promising and sustainable approach where agro-waste product is used as the base material for medical application in wound dressing.
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