Extraction, structural-activity relationships, bioactivities, and application prospects of Pueraria lobata polysaccharides as ingredients for functional products: A review

Pueraria lobata (Willd.) Ohwi is an important resource with dual functions in medicine and food since ancient times. Polysaccharides are the main bioactive component of P. lobata and have various bioactivities, such as antidiabetic, antioxidant, immunological activities, etc. Due to the distinctive bioactivity of P. lobata polysaccharides (PLPs), the research on PLPs is booming. Although a series of PLPs have been isolated and characterized, the chemical structure and mechanism are unclear and need further study. Here, we reviewed recent progress in isolation, identification, pharmacological properties, and possible therapeutic mechanisms of PLPs to update awareness of these value-added natural polysaccharides. Besides, the structure-activity relationships, application status, and toxic effects of PLPs are highlighted and discussed to afford a deeper understanding of PLPs. This article may provide theoretical insights and technical guidance for developing PLPs as novel functional foods.

Automated summary

Pueraria lobata polysaccharides (PLPs) are the main bioactive components of P. lobata, exhibiting various activities such as antidiabetic, antioxidant, and immunological activities. However, the chemical structure and mechanism of PLPs are still unclear and require further study. This review provides an overview of the recent progress in isolation, identification, pharmacological properties, and possible therapeutic mechanisms of PLPs, aiming to update the understanding of these valuable natural polysaccharides. Additionally, the structure-activity relationships, application status, and toxic effects of PLPs are discussed to enhance the comprehension of PLPs.