期刊
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
卷 249, 期 -, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.ijbiomac.2023.126000
关键词
Cell membranes; Biological macromolecules; Inflammatory bowel disease; Nanoparticles; Probiotics; Targeted delivery
Inflammatory bowel disease (IBD) is a serious chronic intestinal disorder that poses challenges in treatment. The emergence of cell membrane nanomaterials (CMNs) has revolutionized IBD treatment by enhancing drug properties and targeting inflammation effectively. This review explores various CMNs delivery systems for IBD treatment and proposes a hierarchically programmed delivery modality for improved efficiency and future research.
Inflammatory bowel disease (IBD) is a serious chronic intestinal disorder with an increasing global incidence. However, current treatment strategies, such as anti-inflammatory drugs and probiotics, have limitations in terms of safety, stability, and effectiveness. The emergence of targeted nanoparticles has revolutionized IBD treatment by enhancing the biological properties of drugs and promoting efficiency and safety. Unlike synthetic nanoparticles, cell membrane nanomaterials (CMNs) consist primarily of biological macromolecules, including phospholipids, proteins, and sugars. CMNs include red blood cell membranes, macrophage membranes, and leukocyte membranes, which possess abundant glycoprotein receptors and ligands on their surfaces, allowing for the formation of cell-to-cell connections with other biological macromolecules. Consequently, they exhibit superior cell affinity, evade immune responses, and target inflammation effectively, making them ideal material for targeted delivery of IBD therapies. This review explores various CMNs delivery systems for IBD treatment. However, due to the complexity and harsh nature of the intestinal microenvironment, the lack of flexibility or loss of selectivity poses challenges in designing single CMNs delivery strategies. Therefore, we propose a hierarchically programmed delivery modality that combines CMNs with pH, charge, ROS and ligand-modified responsive nanoparticles. This approach significantly improves delivery efficiency and points the way for future research in this area.
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