期刊
MICROCHIMICA ACTA
卷 184, 期 1, 页码 155-162出版社
SPRINGER WIEN
DOI: 10.1007/s00604-016-1995-0
关键词
Magnesium ferrite; Multi-walled carbon nanotubes; Cyclic voltammetry; Differential pulse voltammetry; Chronoamperometry; Diclofenac; Morphine; Electrochemical impedance spectroscopy
The paper describes a sensitive method for simultaneous sensing of morphine (MOR) and diclofenac (DCF). The surface of a MgFe2O4/graphite paste electrode was modified with multi-walled carbon nanotubes, and the resulting sensor was characterized by cyclic voltammetry, differential pulse voltammetry, chronoamperometry, and electrochemical impedance spectroscopy. The electrode showed an efficient synergistic effect in term of oxidation of DCF and MOR, with sharp oxidation peaks occurring at +0.370 and 0.540 V (vs Ag/AgCl) at pH 7.0. The calibration plot for MOR is linear in the 50 nM to 920 mu M concentration range, and the detection limit is 10 nM (at a signal-to-noise ratio of 3). The respective data for DCF are 100 nM to 580 mu M, with a 60 nM LOD. The sensor was applied to the determination of MOR and DCF in spiked serum and urine samples, with recoveries ranging between 91.4 and 100.7 %.
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