相关参考文献
注意：仅列出部分参考文献，下载原文获取全部文献信息。
Review
Chemistry, Multidisciplinary
Pascal Bertsch et al.
Summary: Biomaterials that can self-heal and maintain their structural integrity have significant advantages in biomedicine. Self-healing injectable hydrogels, a new type of biomaterial, have emerged in the past decade. These hydrogels can temporarily fluidize and then recover their mechanical properties under shear stress. They can be administered locally and minimally invasively, and have moldable properties for personalized medicine. Additionally, they facilitate tissue regeneration through their viscoelastic and diffusive nature. However, challenges remain in balancing self-healing and injectability with physical stability, establishing consensus on rheological characterization, and translating them into therapeutically effective formulations for specific tissues.
Article
Engineering, Biomedical
Can Wu et al.
Summary: In this study, an injectable conductive hydrogel (Alg-P-AAV hydrogel) with excellent antioxidative and angiogenic ability was developed by incorporating lignosulfonate-doped polyaniline (PANI/LS) nanorods and adeno-associated virus encoding vascular endothelial growth factor (AAV9-VEGF) in the calcium-crosslinked alginate hydrogel. The therapeutic effect of this multi-functional hydrogel for myocardial infarction (MI) treatment was remarkable.
Review
Biochemistry & Molecular Biology
Junyan Tan et al.
Summary: Natural polysaccharide-based hydrogels, especially alginate, have become a research hotspot due to their abundant source, biodegradability, biocompatibility, solubility, and modification flexibility. Various crosslinking strategies and the application progress of alginate-based hydrogels in drug delivery, wound healing, and tissue engineering are comprehensively discussed in this article. The future prospects, challenges, and development trends of alginate-based hydrogels are also explored.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Biochemistry & Molecular Biology
Farooq Azam et al.
Summary: This study investigates the properties of natural fiber-reinforced composite hydrogel fibers for wound dressing application. Kapok and hemp fibers were used as reinforcements to improve the strength of the hydrogel fibers. The prepared composite hydrogel fibers were characterized using FTIR, SEM, and DSC. The results showed that the reinforcement of the fibers enhanced their strength, with hemp fibers exhibiting better mechanical properties.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Biochemistry & Molecular Biology
Lin Zhao et al.
Summary: An electroactive hydrogel was constructed by rapidly forming dynamic imine bonds between oxidized sodium alginate (OSA) and carboxymethyl chitosan (CMCS), and in situ forming silver nanoparticles (AgNPs) by UV irradiation. The hydrogel exhibited injectability, self-healing ability, biocompatibility, and antibacterial activities. It promoted cell proliferation and accelerated wound healing in a skin defect model.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Chemistry, Multidisciplinary
Xiangwu Chen et al.
Summary: An injectable hydrogel constructed from tumor lysates has been developed to address the challenges in T cell-based immunotherapy, such as low immunogenicity, T cell exhaustion, and immune evasion through the PD-1/PD-L1 pathway. The hydrogel provides a robust antigen reservoir to induce strong immunogenicity within the tumor, while also preventing T cell exhaustion through mitophagy and suppressing PD-1 expression to regulate immune evasion. This strategy significantly enhances T cell-based immunotherapy and offers a new approach for cancer treatment.
JOURNAL OF CONTROLLED RELEASE
(2023)
Article
Chemistry, Applied
Shuyuan Cui et al.
Summary: In this study, a cellulose nanofiber-reinforced oxidized alginate/gelatin semi-interpenetrating network hydrogel was successfully synthesized with excellent mechanical properties and multifunctionality. The hydrogel exhibited excellent injectability and self-healing ability, along with outstanding biomineralization and enhanced osteoblast cell viability.
CARBOHYDRATE POLYMERS
(2023)
Article
Engineering, Environmental
Ziling Zhou et al.
Summary: This study explored the enhancement of photocatalytic performance and biocompatibility by doping sulfur in ZIF-8 and combining it with graphene oxide (GO). The composite showed improved photothermal performance and demonstrated effective bacteria-killing ability by destroying bacterial cell membranes and increasing permeability. Furthermore, the slow release of Zn2+ ions from the composite promoted wound healing.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Chemistry, Applied
Trung Thang Vu et al.
Summary: Novel injectable and reduction-responsive hydrogels were successfully prepared in this study. The hydrogels exhibited high swelling ratios, porous morphology, excellent drug loading efficiency, and suitable mechanical properties. Drug release experiments showed that the hydrogels released the encapsulated drug in the presence of glutathione and exhibited anti-tumor activity against cancer cells. These hydrogels have great potential as a biomaterial for stimuli responsive drug delivery applications.
CARBOHYDRATE POLYMERS
(2022)
Article
Engineering, Environmental
Junkai Zeng et al.
Summary: A flexible photothermal biopaper has been developed for rapid healing of infected wounds. The biopaper combines black phosphorus nanosheets and antibacterial hydroxyapatite nanowires, demonstrating stable porous structure, high porosity, good biocompatibility, superior photothermal conversion ability, and antibacterial function. Under near infrared laser irradiation, the biopaper effectively eliminates bacteria and accelerates angiogenesis, promoting wound healing.
CHEMICAL ENGINEERING JOURNAL
(2022)
Article
Engineering, Environmental
Amrita Singh et al.
Summary: The study presents an innovative pesticide formulation using chitosan-alginate-cenosphere composite hydrogel beads for sustained release of imidacloprid, with high encapsulation efficiency and slower release profile under different pH conditions. The formulation shows promise for on-field application and sustainable pest management, as supported by various experiments and safety assessments.
CHEMICAL ENGINEERING JOURNAL
(2022)
Article
Cell Biology
Archita Das et al.
Summary: This study uncovers an important role of the copper transporter CTR1 as a redox sensor in endothelial cells, promoting VEGFR2 signaling and angiogenesis. CTR1 undergoes modifications after redox stress, leading to the formation of CTR1-VEGFR2 complex and enhancing VEGFR2 signaling and angiogenesis.
NATURE CELL BIOLOGY
(2022)
Article
Multidisciplinary Sciences
Donghwan Ji et al.
Summary: In this study, the authors demonstrate the synthesis of superstrong, superstiff, and conductive alginate hydrogels with densely interconnecting networks. By using a simple reconstructing process, they achieve specific mechanical properties required for applications in artificial biological tissues, flexible electronics, and conductive membranes. The hydrogels show exceptional tensile strengths and elastic moduli, and they can also hold cations and exhibit high ionic conductivity.
NATURE COMMUNICATIONS
(2022)
Review
Engineering, Environmental
Zhibin Zhang et al.
Summary: With the development of global industry and the increase of population, the shortage of freshwater resources has become a pressing issue, leading to extensive research on advanced water treatment and water harvesting technologies. Hydrogel, as a polymer material with excellent properties such as water absorption, water retention, and adsorption, has been widely used in water resources harvesting and treatment. This review provides an overview of the synthetic routes of hydrogel materials, the mechanisms of water absorption and desorption, and the recent research progress in atmospheric water harvesting, seawater desalination, and wastewater treatment using hydrogel materials.
CHEMICAL ENGINEERING JOURNAL
(2022)
Review
Chemistry, Multidisciplinary
Suchiwa Pan-On et al.
Summary: Although curcumin has health benefits, its clinical application is limited by its poor solubility and stability. Nanocarrier-based drug delivery systems (NDS) are effective in improving curcumin's physicochemical and pharmacological effects. This study reviewed evidence of lipid and polymer-based NDS for oral delivery of curcumin. Most studies found that NDS increased curcumin absorption compared to free curcumin.
JOURNAL OF CONTROLLED RELEASE
(2022)
Article
Multidisciplinary Sciences
Yujie Zhu et al.
Summary: The study demonstrates that Ca2+-surplus alginate hydrogel can enhance microwave ablation (MWA) therapy by increasing heating efficiency and inducing immunogenic cell death. Synergizing with Mn2+, it can also strengthen antitumor immunity and suppress tumor growth. This finding is of great significance for clinical translation.
Article
Chemistry, Multidisciplinary
Jiale Xia et al.
Summary: By forming a Cu2+-coordinated sodium alginate (Cu-SA) layer on the surface of CuF2, copper dissolution is successfully suppressed, improving the reversibility of CuF2. The CuF2 electrode with SA binder delivers a reversible capacity of 420.4 mAh g(-1) after 50 cycles, reaching an energy density of 1009.1 Wh kg(-1).
ADVANCED MATERIALS
(2022)
Article
Biochemistry & Molecular Biology
Mengmeng Xie et al.
Summary: A multifunctional hydrogel has been developed that can rapidly stop bleeding and has antibacterial properties, promoting wound healing and repair. The hydrogel has good water retention capacity and mimics the three-dimensional structure of the natural extracellular matrix, making it promising for applications in hemostasis and wound healing.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Biochemistry & Molecular Biology
Aditya K. Kar et al.
Summary: A Guar Gum-based macroporous hydrogel infused with antibacterial agent and antioxidant can promote wound healing and inhibit bone infection in a high-fat-diet-induced diabetes mice model. The hydrogel facilitates scar-free wound healing through enhanced cell proliferation, tissue fiber formation, void space reduction, and re-epithelialization.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Chemistry, Applied
Catharina Kroemmelbein et al.
Summary: Granular hydrogels with injectability and porosity have shown great potential in biomedicine. High-energy electron irradiation is used to sterilize and tune the properties of the hydrogels without cytotoxic chemicals. This study presents the mechanical characterization of electron irradiated granular agarose/alginate hydrogels, showing size reduction and gel softening under radiation. However, the shear-thinning and self-healing properties remain, enabling injection of the hydrogel through a needle.
CARBOHYDRATE POLYMERS
(2022)
Review
Emergency Medicine
Jessica Salvo et al.
Summary: This review aims to explore the importance of copper nanoparticles in wound healing. Copper nanoparticles combat infection through multiple mechanisms and play a significant role in various stages of wound healing by modulating cytokines and growth factors.
Article
Engineering, Biomedical
Jung Ju Seo et al.
Summary: The study introduces a nanoglass paste for promoting bone tissue regeneration, antibacterial effects, and enhancing angiogenesis. The paste releases multiple ions, acting as a therapeutic ions reservoir in surrounding cells. Experimentally, the nanoglass paste showed significant effects on promoting osteogenic differentiation, angiogenesis, and bactericidal properties.
Review
Chemistry, Multidisciplinary
Tamara Birman et al.
Summary: Balancing between chemical and biological functionality is crucial to achieve injectability in hydrogels through specific crosslinking pathways, while maintaining cell compatibility. With the emergence of new injectable biosynthetic materials, their impact in cell therapy and bioprinting is becoming increasingly significant.
ADVANCED FUNCTIONAL MATERIALS
(2021)
Article
Chemistry, Multidisciplinary
Li Yu et al.
Summary: The synergistic antibacterial system developed in this study by modifying Cu2+ and CTAB into montmorillonite (MMT) for a polyglycolic acid (PGA) scaffold showed significantly improved antibacterial activities against E. coli, with an antibacterial rate of 98.1%, due to enhanced bacterial adsorption capacity and increased zeta potential.
MATERIALS CHEMISTRY FRONTIERS
(2021)
Article
Biochemistry & Molecular Biology
Neeraj K. Verma et al.
Summary: This study developed an optimized osteogenic scaffold, AD/EGCG-g-NOCC@clgn I, which stimulated MSCs towards osteoblast differentiation and promoted swift bone regeneration in calvarial defects in mice. The 3D matrix provided a favorable microenvironment and structural support for accelerated bone formation and union.
Article
Engineering, Environmental
Paria Ghaderinejad et al.
Summary: Research interest is growing in designing a tissue regenerative matrix for effective nerve injury repair, such as the injectable alginate hydrogel with magnetic PCL short nanofibers. The alignment of short fibers by external magnetic fields affects fiber orientation and can accelerate neural differentiation of stem cells in hybrid hydrogels. These ordered injectable hydrogels show promise for minimal invasive neural tissue regeneration.
CHEMICAL ENGINEERING JOURNAL
(2021)
Article
Chemistry, Multidisciplinary
Jin Zhou et al.
Summary: This study proposes a new strategy for cardiac repair using melanin nanoparticles/alginate hydrogels, which possess antioxidant properties and promote macrophage polarization. The experiments in an MI rat model demonstrate that the hydrogel has good antioxidant, anti-inflammatory, and proangiogenesis effects.
Review
Chemistry, Applied
Aurora C. Hernandez-Gonzalez et al.
CARBOHYDRATE POLYMERS
(2020)
Article
Biochemistry & Molecular Biology
Kitipong Kiti et al.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2020)
Review
Biochemistry & Molecular Biology
Miao Zhang et al.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2020)
Article
Biochemistry & Molecular Biology
Wooyoung Kim et al.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2018)
Review
Polymer Science
Hiroyuki Kojima
Article
Chemistry, Physical
Jie Liu et al.
JOURNAL OF MATERIALS CHEMISTRY A
(2018)
Article
Multidisciplinary Sciences
Jeong-Yun Sun et al.
