Progress in construction and release of natural polysaccharide-platinum nanomedicines: A review

Natural polysaccharides are natural biomaterials that have become candidate materials for nano-drug delivery systems due to their excellent biodegradability and biocompatibility. Platinum (Pt) drugs have been widely used in the clinical therapy for various solid tumors. However, their extensive systemic toxicity and the drug resis-tance acquired by cancer cells limit the applications of platinum drugs. Modern nanobiotechnology provides the possibility for targeted delivery of platinum drugs to the tumor site, thereby minimizing toxicity and optimizing the efficacies of the drugs. In recent years, numerous natural polysaccharide-platinum nanomedicine delivery carriers have been developed, such as nanomicelles, nanospheres, nanogels, etc. Herein, we provide an overview on the construction and drug release of natural polysaccharide-Pt nanomedicines in recent years. Current challenges and future prospectives in this field are also put forward. In general, combining with irradiation and tumor microenvironment provides a significant research direction for the construction of natural polysaccharide-platinum nanomedicines and the release of responsive drugs in the future.

Automated summary

Natural polysaccharides are excellent biomaterials for nano-drug delivery systems due to their biodegradability and biocompatibility. Platinum drugs, widely used in clinical therapy, face limitations such as toxicity and drug resistance. Recent development of natural polysaccharide-platinum nanomedicines, such as nanomicelles and nanospheres, offer potential solutions to minimize toxicity and optimize drug efficacy through targeted delivery. Future research directions include combining with irradiation and tumor microenvironment for responsive drug release.