期刊
MICROCHIMICA ACTA
卷 183, 期 9, 页码 2539-2546出版社
SPRINGER WIEN
DOI: 10.1007/s00604-016-1895-3
关键词
Chemical sensor; Anodization; Cyclic voltammetry; Differential pulse voltammetry; Ascorbic acid; Dopamine; Uric acid; Urine analysis
资金
- National Natural Science Foundation of China [21475041, 21175042]
- Hunan Lotus Scholars Program
A glassy carbon electrode (GCE) was anodically oxidized by cyclic voltammetry (CV) in 0.05 M sulfuric acid to introduce hydroxy groups on its surface (GCE(ox)). Next, an imidazolium alkoxysilane (ImAS) is covalently tethered to the surface of the GCE(ox) via silane chemistry. This electrode is further modified with graphene oxide (GO) which, dispersed in water, spontaneously assembles on the electrode surface through electrostatic interaction and pi-interaction to give an electrode of type GO/ImAS/GCE. Electroreduction of GO and GCE(ox) by CV yields electroreduced GO (erGO) and an electrode of the type erGO/ImAS/GCE. This electrode displays excellent electrocatalytic activity for the oxidation of ascorbic acid (AA), dopamine (DA) and uric acid (UA). Three fully resolved anodic peaks (at -50 mV, 150 mV and 280 mV vs. Ag/AgCl) are observed during differential pulse voltammetry (DPV). Under optimized conditions, the linear detection ranges are from 30 to 2000 mu M for AA, from 20 to 490 mu M for UA, and from 0.1 to 5 mu M and from 5 mu M to 200 mu M (two linear ranges) for DA. The respective limits of detection (for an S/N of 3) are 10 mu M, 5 mu M and 0.03 mu M. The GCE modified with erGO and ImAS performs better than a bare GCE or a GCE modified with ImAS only, and also outperforms many other reported electrodes for the three analytes. The method was successfully applied to simultaneous analysis of AA, DA and UA in spiked human urine.
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