In-vitro activity of oral third-generation cephalosporins plus clavulanate against ESBL-producing Enterobacterales isolates from the MERINO trial

Article Infectious Diseases

Oral ciprofloxacin activity against ceftriaxone-resistant Escherichia coli in an in vitro bladder infection model

Iain J. Abbott et al.

Summary: The study found that high-dose oral ciprofloxacin therapy (750 mg 12 hourly) has good antibacterial activity against ceftriaxone-resistant Escherichia coli, especially with ciprofloxacin MIC <= 1 mg/L.

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY (2023)

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Article Medicine, General & Internal

Oral Tebipenem Pivoxil Hydrobromide in Complicated Urinary Tract Infection

Paul B. Eckburg et al.

Summary: This study demonstrated the noninferiority of orally administered tebipenem pivoxil hydrobromide compared to intravenous ertapenem in the treatment of complicated urinary tract infection and acute pyelonephritis, with similar safety profiles.

NEW ENGLAND JOURNAL OF MEDICINE (2022)

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Article Infectious Diseases

Determining the in vitro susceptibility of tebipenem, an oral carbapenem, against third-generation cephalosporin-resistant Escherichia coli and Klebsiella pneumoniae isolated from bloodstream infections

Ama Ranasinghe et al.

Summary: Tebipenem's in vitro activity is not affected by the production of ESBL and AmpC enzymes, and it retains its activity against strains resistant to ciprofloxacin and trimethoprim/sulfamethoxazole.

JAC-ANTIMICROBIAL RESISTANCE (2022)

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Review Infectious Diseases

The global prevalence and trend of human intestinal carriage of ESBL-producing Escherichia coli in the community

Yihienew M. Bezabih et al.

Summary: There has been a significant increase in the intestinal carriage rate of ESBL E. coli in the community globally over the past 20 years, with the highest rates observed in South-East Asia and the lowest in Europe. Prevention of its spread may require new therapeutic and public health strategies.

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY (2021)

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Article Microbiology

Molecular Epidemiology of Third-Generation-Cephalosporin-Resistant Enterobacteriaceae in Southeast Queensland, Australia

A. G. Stewart et al.

Summary: This study collected 288 3GC-R Enterobacteriaceae isolates from a regional Australian hospital and utilized rapid PCR assays to detect various beta-lactamase genes. The majority of isolates were found to harbor at least one beta-lactamase gene, and whole-genome sequencing confirmed the accuracy of the detection methods.

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2021)

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Editorial Material Infectious Diseases

Oral Antibiotics in Clinical Development for Community-Acquired Urinary Tract Infections

Balaji Veeraraghavan et al.

Summary: The treatment of urinary tract infections is complicated by multidrug-resistant pathogens expressing beta-lactamase. The emergence of oral antibiotics active against extended-spectrum beta-lactamase uropathogens is needed, with various drugs in clinical development. These new drugs have potential broad-spectrum coverage against resistant strains and will strengthen outpatient therapy.

INFECTIOUS DISEASES AND THERAPY (2021)

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Review Infectious Diseases