Peficitinib ameliorates 5-fluorouracil-induced intestinal damage by inhibiting aging, inflammatory factors and oxidative stress

Article Immunology

Artesunate ameliorates irinotecan-induced intestinal injury by suppressing cellular senescence and significantly enhances anti-tumor activity

Hui Jie Jia et al.

Summary: This article examines the side effects of irinotecan in cancer treatment, finding that it causes intestinal toxicity and cellular senescence. However, using artesunate can alleviate these side effects and inhibit tumor growth.

INTERNATIONAL IMMUNOPHARMACOLOGY (2023)

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Article Biochemistry & Molecular Biology

Anti-inflammation and anti-aging mechanisms of mercaptopurine in vivo and in vitro

HuiJie Jia et al.

Summary: This study found that mercaptopurine inhibits cellular and animal senescence, and exhibits anti-inflammatory effects in UV-B-induced skin damage and photoaging. It achieves this by suppressing important signaling molecules MAPK and NF-kB, increasing collagen fiber content, and facilitating collagen synthesis, thereby protecting the skin from UV-B damage.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2023)

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Review Biochemistry & Molecular Biology

Pancreatic Cancer and Cellular Senescence: Tumor Microenvironment under the Spotlight

Michela Cortesi et al.

Summary: Pancreatic ductal adenocarcinoma (PDAC) has a poor prognosis due to immune suppression and the tumor microenvironment. This review explores the interplay between senescent and non-senescent cell types and their impact on PDAC progression. The non-tumoral cells in the tumor microenvironment influence key aspects of tumor growth, metabolism, cell death, and treatment resistance. Understanding these interactions is crucial for PDAC treatment.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

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Article Multidisciplinary Sciences

Effect of acute high-intensity exercise on myocardium metabolic profiles in rat and human study via metabolomics approach

Lijun Wu et al.

Summary: This study aimed to explore the effects of acute high-intensity exercise on rat myocardial metabolism and evaluate its diagnostic potential for sports injuries. It was found that acute high-intensity exercise caused changes in myocardial metabolism, including disorders in complex lipids and fatty acids, an increase in purine degradation products, and signs of impaired glucose metabolism. Additionally, amino acids were enhanced and exerted a protective effect on the myocardium.

SCIENTIFIC REPORTS (2022)

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Review Nutrition & Dietetics

Tea Polyphenols as Prospective Natural Attenuators of Brain Aging

Mengyu Hong et al.

Summary: Aging is inevitable and often accompanied by chronic disease. Tea polyphenols have potential anti-aging benefits by regulating the composition of the intestinal microbiota. The interaction between human neurological function and the gut microbiota suggests that tea polyphenols can be an effective intervention to alleviate brain-aging.

NUTRIENTS (2022)

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Article Radiology, Nuclear Medicine & Medical Imaging

Study on Huangqi Bazhen Decoction on Relieving Chemotherapy Intestinal Mucositis in Capecitabine Gavage Mice

Tieyi Shi et al.

Summary: This study investigated the therapeutic effect and mechanism of Huangqi Bazhen decoction on chemotherapeutic intestinal mucositis induced by capecitabine in mice, in order to provide evidence for clinical application. The experimental results showed that Huangqi Bazhen decoction reversed the morphological features of intestinal injury and significantly reduced weight loss and diarrhea during capecitabine treatment. Furthermore, it was found that Huangqi Bazhen decoction improved antioxidant enzyme levels and significantly reduced inflammation markers.

CONTRAST MEDIA & MOLECULAR IMAGING (2022)

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Article Pharmacology & Pharmacy

Network analysis and experimental pharmacology study explore the protective effects of Isoliquiritigenin on 5-fluorouracil-Induced intestinal mucositis

Yi-fan Liao et al.

Summary: This study investigated the impact of isoliquiritigenin (ISL) on 5-fluorouracil (5-FU)-induced intestinal mucositis. Network analysis and molecular docking were used to predict the targets and mechanism of ISL, which were then validated in a mouse model. The results suggested that ISL could attenuate 5-FU-induced intestinal mucositis by regulating the TNF/NF-κB pathway and inhibiting inflammatory mediators PTGS2 and NOS2.

FRONTIERS IN PHARMACOLOGY (2022)

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Review Oncology

Exploiting senescence for the treatment of cancer

Liqin Wang et al.

Summary: This review discusses how senescence can be induced in cancer cells and how the distinctive features of senescent cancer cells can be exploited for selective eradication. It also explores activation of the host immune system as an attractive way to clear senescent cancer cells, and the potential benefits of a sequential treatment approach with pro-senescence therapy followed by senolytic therapy.

NATURE REVIEWS CANCER (2022)

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Review Biochemistry & Molecular Biology

Molecular Aspects of Senescence and Organismal Ageing-DNA Damage Response, Telomeres, Inflammation and Chromatin

Natalia Slawinska et al.

Summary: Cells can become senescent in response to stress, which can be beneficial in some cases like suppressing tumour development or promoting tissue repair, but may also contribute to the ageing process.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Article Geriatrics & Gerontology

Senolytic Combination of Dasatinib and Quercetin Alleviates Intestinal Senescence and Inflammation and Modulates the Gut Microbiome in Aged Mice

Tatiana Dandolini Saccon et al.

Summary: The study found that the senolytic drug combination Dasatinib plus Quercetin (D+Q) significantly reduces senescent cell and inflammatory burden in the intestines of aged mice, while also altering specific microbiota signatures. The most prominent changes were observed in the small intestine. This suggests that optimized senolytic regimens may improve health in older subjects by reducing intestinal senescence, inflammation, and microbial dysbiosis.

JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES (2021)

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Review Biochemistry & Molecular Biology

The Era of Janus Kinase Inhibitors for Inflammatory Bowel Disease Treatment

Jin-Woo Kim et al.

Summary: Treatment response in inflammatory bowel disease (IBD) remains a significant issue, with anti-tumor necrosis factor therapies and Janus kinase inhibitors offering potential solutions. While effective in ulcerative colitis (UC), Janus kinase inhibitors show less efficacy in Crohn's disease (CD). Safety concerns persist due to the immune-system-based mechanism of these drugs.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Article Toxicology

Amelioration of N,N′-dimethylhydrazine induced colon toxicity by epigallocatechin gallate in Wistar rats

S. M. Afzal et al.

Summary: Colon cancer is a life-threatening disease associated with oxidative stress and inflammation. EGCG protects the colon from the toxic effects of DMH through its antioxidant and anti-inflammatory properties.

HUMAN & EXPERIMENTAL TOXICOLOGY (2021)

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Article Biochemistry & Molecular Biology

Therapeutic Potential for Regulation of the Nuclear Factor Kappa-B Transcription Factor p65 to Prevent Cellular Senescence and Activation of Pro-Inflammatory in Mesenchymal Stem Cells

Rocio Mato-Basalo et al.

Summary: Mesenchymal stem cells have potential in treating age-related diseases, and small extracellular vesicles derived from these cells have been proposed as therapies. The activation of p65 is found to be important in cellular senescence and inflammatory activation in mesenchymal stem cells. Inhibiting p65 can prevent cellular senescence and the activation of proinflammatory molecules, highlighting its role in restoring functionality and preventing inflamm-aging.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Editorial Material Oncology

Editorial: Repurposed Drugs Targeting Cancer Signaling Pathways: Dissecting New Mechanism of Action Through In Vitro and In Vivo Analyses

Eduardo Lopez-Urrutia et al.

FRONTIERS IN ONCOLOGY (2021)

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Article Plant Sciences

Anti-inflammatory effects of Radix Aucklandiae herbal preparation ameliorate intestinal mucositis induced by 5-fluorouracil in mice

Ju-Han Liu et al.

Summary: The Radix Aucklandiae herbal preparation effectively ameliorates 5-FU-induced intestinal mucositis in mice, improving appetite, body weight, and diarrhea, and displaying protective effects. It also suppresses the activation of NF-kappa B and proinflammatory cytokines.

JOURNAL OF ETHNOPHARMACOLOGY (2021)

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Article Oncology

Therapy-Induced Senescence: Opportunities to Improve Anticancer Therapy

Pataje G. Prasanna et al.

Summary: Cellular senescence is crucial in suppressing tumor growth, but radiation and chemotherapy can lead to accumulation of senescent cells in both tumor and normal tissues, potentially promoting tumor relapse and resistance to treatment. Targeting cellular senescence could be important in the fight against cancer.

JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE (2021)

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Article Cell & Tissue Engineering

Advanced oxidation protein products induce inflammatory responses and invasive behaviour in fibroblast-like synoviocytes via the RAGE-NF-κB pathway

Aiju Lou et al.

Bone & Joint Research (2021)

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Review Pharmacology & Pharmacy

Chemotherapeutics-Induced Intestinal Mucositis: Pathophysiology and Potential Treatment Strategies

David Dahlgren et al.

Summary: Chemotherapeutics-induced intestinal mucositis (CIM) is a common gastrointestinal toxicity in cancer patients due to the rapid proliferation of intestinal epithelial cells and complex immunological interactions with gut microbiota. CIM often leads to dose-reduction, decreasing the efficacy of anticancer treatment, and effective strategies for prevention and treatment are still lacking.

FRONTIERS IN PHARMACOLOGY (2021)

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Article Gastroenterology & Hepatology

Efficacy of JAK inhibitors in Ulcerative Colitis

Marc Ferrante et al.

JOURNAL OF CROHNS & COLITIS (2020)

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Article Gastroenterology & Hepatology

JAK Inhibitors Safety in Ulcerative Colitis: Practical Implications

Manasi Agrawal et al.

JOURNAL OF CROHNS & COLITIS (2020)

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Article Geriatrics & Gerontology

Aging Increases the Severity of Colitis and the Related Changes to the Gut Barrier and Gut Microbiota in Humans and Mice

Ailing Liu et al.

JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES (2020)

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Review Oncology

Cardiotoxicities of 5-Fluorouracil and Other Fluoropyrimidines

Taro Shiga et al.

CURRENT TREATMENT OPTIONS IN ONCOLOGY (2020)

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Review Oncology

Senescent Cells in Cancer Therapy: Friends or Foes?

Boshi Wang et al.

TRENDS IN CANCER (2020)

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Review Pharmacology & Pharmacy

JAK3-selective inhibitor peficitinib for the treatment of rheumatoid arthritis

Qian Qiu et al.

EXPERT REVIEW OF CLINICAL PHARMACOLOGY (2019)

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Article Biochemistry & Molecular Biology

CO ameliorates endothelial senescence induced by 5-fluorouracil through SIRT1 activation

Min Zheng et al.

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS (2019)

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Article Pharmacology & Pharmacy

Diadzein ameliorates 5-fluorouracil-induced intestinal mucositis by suppressing oxidative stress and inflammatory mediators in rodents

Ayesha Atiq et al.

EUROPEAN JOURNAL OF PHARMACOLOGY (2019)

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Article Gastroenterology & Hepatology

Peficitinib, an Oral Janus Kinase Inhibitor, in Moderate-to-severe Ulcerative Colitis: Results From a Randomised, Phase 2 Study

Bruce E. Sands et al.

JOURNAL OF CROHNS & COLITIS (2018)

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Article Pharmacology & Pharmacy

A novel JAK inhibitor, peficitinib, demonstrates potent efficacy in a rat adjuvant-induced arthritis model

Misato Ito et al.

JOURNAL OF PHARMACOLOGICAL SCIENCES (2017)

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Review Oncology

Biology of premature ageing in survivors of cancer

Margaret C. Cupit-Link et al.

ESMO OPEN (2017)

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Article Pharmacology & Pharmacy

5-fluorouracil causes endothelial cell senescence: potential protective role of glucagon-like peptide 1

Paola Altieri et al.

BRITISH JOURNAL OF PHARMACOLOGY (2017)

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Article Oncology

Therapy-Induced Cellular Senescence Induces Epithelial-to-Mesenchymal Transition and Increases Invasiveness in Rectal Cancer

Joana Tato-Costa et al.

CLINICAL COLORECTAL CANCER (2016)

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Review Nutrition & Dietetics

Biomarkers of Aging: From Function to Molecular Biology

Karl-Heinz Wagner et al.

NUTRIENTS (2016)

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Article Biology

Alanyl-glutamine attenuates 5-fluorouracil-induced intestinal mucositis in apolipoprotein E-deficient mice

C. V. Araujo et al.

BRAZILIAN JOURNAL OF MEDICAL AND BIOLOGICAL RESEARCH (2015)

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Article Multidisciplinary Sciences

JAK inhibition alleviates the cellular senescence-associated secretory phenotype and frailty in old age

Ming Xu et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2015)

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Article Multidisciplinary Sciences

Saireito (TJ-114), a Japanese Traditional Herbal Medicine, Reduces 5-Fluorouracil-Induced Intestinal Mucositis in Mice by Inhibiting Cytokine-Mediated Apoptosis in Intestinal Crypt Cells

Shinichi Kato et al.

PLOS ONE (2015)

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Review Oncology

Guidance on the management of diarrhoea during cancer chemotherapy

Jervoise Andreyev et al.

LANCET ONCOLOGY (2014)

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Article Gastroenterology & Hepatology

Gastro-intestinal toxicity of chemotherapeutics in colorectal cancer: The role of inflammation

Chun Seng Lee et al.

WORLD JOURNAL OF GASTROENTEROLOGY (2014)

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Review Cell Biology

Inflammatory signaling and cellular senescence

Jian-Lin Ren et al.

CELLULAR SIGNALLING (2009)

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Article Oncology

Gastrointestinal dysmotility in 5-fluorouracil-induced intestinal mucositis outlasts inflammatory process resolution

Pedro M. G. Soares et al.

CANCER CHEMOTHERAPY AND PHARMACOLOGY (2008)

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Review Multidisciplinary Sciences

Cancer-related inflammation

Alberto Mantovani et al.

NATURE (2008)

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Review Cell Biology

Cellular senescence: when bad things happen to good cells

Judith Campisi et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2007)

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Review Oncology

Perspectives on cancer therapy-induced mucosal injury - Pathogenesis, measurement, epidemiology, and consequences for patients

ST Sonis et al.

CANCER (2004)

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Review Biochemistry & Molecular Biology

Missing pieces in the NF-κB puzzle

S Ghosh et al.

CELL (2002)

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Peficitinib ameliorates 5-fluorouracil-induced intestinal damage by inhibiting aging, inflammatory factors and oxidative stress

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