4.7 Article

High-Dose immunoglobulin Intervention as an effective and simple strategy for donor specific Anti-HLA antibody desensitization in haploidentical transplant

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Review Biophysics

The impact of HLA donor-specific antibodies on engraftment and the evolving desensitization strategies

Brittany File et al.

Summary: This article provides an update on the testing and monitoring of donor-specific anti-HLA antibodies (DSA) in contemporary allogeneic hematopoietic stem cell transplantation (HCT) procedures. It reviews the impact of DSA on stem cell engraftment and presents promising desensitization modalities. The article aims to provide practical recommendations for DSA screening and mitigation strategies.

BONE MARROW TRANSPLANTATION (2022)

Article Medicine, General & Internal

Comparable Outcomes in Acquired Severe Aplastic Anemia Patients With Haploidentical Donor or Matched Related Donor Transplantation: A Retrospective Single-Center Experience

QingYun Wang et al.

Summary: Retrospective analysis of clinical data of patients with severe aplastic anemia (SAA) showed that haploidentical hematopoietic stem cell transplantation (HID-HSCT) and matched related sibling hematopoietic stem cell transplantation (MSD-HSCT) had similar outcomes in complications and survival. HID-HSCT could be a safe and effective option for SAA patients without a matched donor.

FRONTIERS IN MEDICINE (2022)

Article Hematology

Successful desensitization of high level donor-specific anti-HLA antibody in patients with hematological diseases receiving haploidentical allografts

Xiaoli Zheng et al.

Summary: The combination of rituximab, high-dose IVIG, and PE proved to be effective in desensitizing haploidentical allograft recipients with high levels of DSA, leading to successful hematopoietic recovery and overall good survival outcomes.

ANNALS OF HEMATOLOGY (2022)

Review Immunology

Donor specific HLA antibody in hematopoietic stem cell transplantation: Implications for donor selection

Scott M. Krummey et al.

Summary: Advances in hematopoietic stem cell transplant have led to changes in donor selection approach, including the use of haploidentical donors or permissive HLA mismatches. However, this may increase the risk of donor-specific HLA antibodies, which can limit engraftment. Desensitization treatments can effectively reduce HLA antibodies and improve transplant outcomes. The consideration and management of HLA antibodies in donor selection are increasingly important in HSCT.

FRONTIERS IN IMMUNOLOGY (2022)

Article Immunology

Management of Donor-Specific Antibodies in Haploidentical Transplant: Multicenter Experience From the Madrid Group of Hematopoietic Transplant

Rebeca Bailen et al.

Summary: This study reports the experience of using desensitization treatments for patients with DSAs undergoing haplo-HSCT. The results show that utilizing desensitization strategies guided by DSAs intensity kinetics can effectively decrease DSA intensity and improve engraftment rates.

FRONTIERS IN IMMUNOLOGY (2021)

Review Immunology

Emerging New Approaches in Desensitization: Targeted Therapies for HLA Sensitization

Ashley Y. Choi et al.

Summary: Sensitized patients with preformed or de novo DSA are at increased risk of AMR and allograft loss. Conventional desensitization methods targeting antibody or B cell removal often fail to efficiently clear all DSA, so interventions targeting multiple components of humoral immunity are needed to improve patient outcomes.

FRONTIERS IN IMMUNOLOGY (2021)

Article Hematology

Treatment of allosensitized patients receiving allogeneic transplantation

Stefan O. Ciurea et al.

Summary: DSAs are a major cause of engraftment failure in HaploSCT patients. Treatment with PE, rituximab, IVIg, and donor buffy coat is effective in promoting engraftment in patients with DSAs 20,000 MFI or below.

BLOOD ADVANCES (2021)

Review Hematology

Donor-Specific Antibodies and Primary Graft Failure in Allogeneic Hematopoietic Stem Cell Transplantation: A Systematic Review and Meta-Analysis

Yiyu Xie et al.

Summary: The prior presence of anti-HLA DSAs has a negative impact on graft outcomes in recipients of haploidentical and umbilical cord blood HSCT.

TRANSPLANTATION AND CELLULAR THERAPY (2021)

Review Surgery

Caveats of HLA antibody detection by solid-phase assays

Caroline Wehmeier et al.

TRANSPLANT INTERNATIONAL (2020)

Article Hematology

Class I and II HLA antibodies in pediatric patients with thalassemia major

Marianne E. McPherson Yee et al.

TRANSFUSION (2016)

Article Hematology

Donor Immunization Against Human Leukocyte Class II Antigens is a Risk Factor for Graft-versus-Host Disease

Florent Delbos et al.

BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION (2016)

Review Immunology

Donor-Specific Anti-HLA Antibodies in Allogeneic Hematopoietic Stem Cell Transplantation

Sarah Morin-Zorman et al.

FRONTIERS IN IMMUNOLOGY (2016)

Review Pediatrics

HLA sensitisation: can it be prevented?

Lesley Rees et al.

PEDIATRIC NEPHROLOGY (2015)

Letter Biophysics

A strategy to reduce donor-specific HLA Abs before allogeneic transplantation

U. Gergis et al.

BONE MARROW TRANSPLANTATION (2014)