☆ 4.7 Article

Immune and inflammatory mechanisms and therapeutic targets of gout: An update

INTERNATIONAL IMMUNOPHARMACOLOGY (2023)

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Loganin Alleviates Gout Inflammation by Suppressing NLRP3 Inflammasome Activation and Mitochondrial Damage

Nuri Choi et al.

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Neutrophil extracellular traps release in gout and pseudogout depends on the number of crystals regardless of leukocyte count

Estrella Garcia-Gonzalez et al.

Summary: The study found that during gout and pseudogout attacks, neutrophils in synovial fluid release NETs when encountering MSU and CPPD crystals, regardless of neutrophil density and crystal type. This release is accompanied by necroptosis through the activation of MLKL pathway.

RHEUMATOLOGY (2021)

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A Randomized, Phase II Study Evaluating the Efficacy and Safety of Anakinra in the Treatment of Gout Flares

Kenneth G. Saag et al.

Summary: In this study evaluating the efficacy and safety of anakinra compared to triamcinolone in the treatment of gout flares, it was found that anakinra and triamcinolone had comparable efficacy in reducing pain intensity, with anakinra performing better in most secondary end points. Anakinra is considered an effective option for gout flares when conventional therapy is unsuitable.

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Qu-Zhuo-Tong-Bi Decoction Alleviates Gouty Arthritis by Regulating Butyrate-Producing Bacteria in Mice

Xianghui Wen et al.

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Umut Can Kucuksezer et al.

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Elevated interleukin-37 associated with tophus and pro-inflammatory mediators in Chinese gout patients

Liping Ding et al.

Summary: IL-37 levels were found to be higher in active gout patients, particularly those with tophus. There was no significant difference in serum IL-37 levels between hyperuricemia and normal controls. IL-37 was positively correlated with CRP, ESR, IL-1 beta, IL-6, and IL-18, negatively correlated with Ccr, and not correlated with UA, Cr, and TG in gout patients.

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Galectin-9 Regulates Monosodium Urate Crystal-Induced Gouty Inflammation Through the Modulation of Treg/Th17 Ratio

Adel Abo Mansour et al.

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Purinergic Signaling in the Regulation of Gout Flare and Resolution

Xiaoling Li et al.

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被撤回的出版物: NFIL3 Facilitates Neutrophil Autophagy, Neutrophil Extracellular Trap Formation and Inflammation During Gout via REDD1-Dependent mTOR Inactivation (Retracted article. See vol. 10, 2023)

Honghu Tang et al.

Summary: NFIL3 is highly expressed in gout patients and promotes neutrophil autophagy and NET formation by enhancing REDD1 transcription; REDD1 enhances neutrophil autophagy and NET formation by inhibiting the mTOR pathway, and silencing NFIL3 reduces inflammatory injury in acute gouty arthritis mice.

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Gout

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Summary: Gout is a common and treatable disease caused by the deposition of monosodium urate crystals in the body, leading to arthritis. Long-term urate lowering therapy is effective in preventing gout flares and improving quality of life.

LANCET (2021)

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Article Medicine, Research & Experimental

Total glucosides of paeony protects THP-1 macrophages against monosodium urate-induced inflammation via MALAT1/miR-876-5p/NLRP3 signaling cascade in gouty arthritis

Qingliang Meng et al.

Summary: The study revealed that total glucosides of paeony (TGP) could suppress MSU-induced inflammation in THP-1 macrophages by regulating the MALAT1/miR-876-5p/NLRP3 axis and the TLR4/MyD88/NF-κB pathway.

BIOMEDICINE & PHARMACOTHERAPY (2021)

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Article Endocrinology & Metabolism

NLRP3 inflammasome inhibitor cucurbitacin B suppresses gout arthritis in mice

Ying Xue et al.

Summary: Cucurbitacin B has anti-inflammatory effects on gout by inhibiting NLRP3 inflammasome activation in macrophages, reducing IL-1 beta secretion, and ameliorating symptoms and inflammatory cell infiltration in a mouse model of gout arthritis.

JOURNAL OF MOLECULAR ENDOCRINOLOGY (2021)

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Article Rheumatology

Dietary and Lifestyle-Centered Approach in Gout Care and Prevention

Chio Yokose et al.

Summary: The global burden of gout is increasing, and a low-purine diet may lead to metabolic syndrome, while healthy dietary patterns associated with cardiovascular health are more beneficial.

CURRENT RHEUMATOLOGY REPORTS (2021)

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Review Immunology

Current Understanding of IL-37 in Human Health and Disease

Zhangci Su et al.

Summary: IL-37, a recently discovered cytokine in the IL-1 family, exerts broad protective effects on inflammatory diseases, autoimmune diseases, and cancer by suppressing cytokine production and promoting anti-inflammatory signals through complex signaling pathways involving Smad3, NF-kappa B, MAPK, Mer-PTEN-DOK pathways, and regulation of macrophage polarization, lipid metabolism, inflammasome function, TSLP synthesis, and miRNAs function. Additionally, IL-37 shows potential as a therapeutic target and biomarker in various diseases due to its aberrant expression in patients with inflammatory diseases, autoimmune diseases, and cancer.

FRONTIERS IN IMMUNOLOGY (2021)

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Article Neurosciences

Mast cell stabilizer ketotifen fumarate reverses inflammatory but not neuropathic-induced mechanical pain in mice

Carolina B. Meloto et al.

Summary: The study demonstrated that treatment with ketotifen fumarate (KF) could produce analgesic effects in pain models in mice, particularly in alleviating inflammatory-induced mechanical nociception. In a case series of patients, it was found that KF treatment led to improvements in patients' quality of life related to pain and comorbid symptoms.

PAIN REPORTS (2021)

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Article Rheumatology

A neutrophil signature is strongly associated with increased cardiovascular risk in gout

Daisy Vedder et al.

Summary: The study revealed elevated levels of neutrophil activation markers, MPO and calprotectin, in gout patients compared to healthy controls. These markers were associated with various risk factors for cardiovascular disease, including hyperlipidemia, hypertension, and diabetes. Furthermore, the presence of a neutrophil activation signature was strongly linked to an increased 10-year risk of cardiovascular mortality in these patients.

RHEUMATOLOGY (2021)

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Article Immunology

1′-Acetoxychavicol acetate inhibits NLRP3-dependent inflammasome activation via mitochondrial ROS suppression

Sophia P. M. Sok et al.

Summary: The natural compound 1'-Acetoxychavicol acetate (ACA) was found to inhibit NLRP3 inflammasome activation in mouse and human cells, along with suppression of molecules and oxidative processes associated with NLRP3 activation. In mouse models, ACA also showed efficacy in preventing NLRP3 inflammasome activation.

INTERNATIONAL IMMUNOLOGY (2021)

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Review Immunology

Tranilast: a potential anti-Inflammatory and NLRP3 inflammasome inhibitor drug for COVID-19

Ali Saeedi-Boroujeni et al.

Summary: SARS-CoV-2 causes acute pneumonia, an inflammatory disease, while a cytokine storm is a major cause of death in COVID-19 patients. Activation of NLRP3 inflammasome by SARS-CoV through complex interactions with the host immune system triggers acute inflammation.

IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY (2021)

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Review Rheumatology

2018 updated European League Against Rheumatism evidence-based recommendations for the diagnosis of gout

Pascal Richette et al.

ANNALS OF THE RHEUMATIC DISEASES (2020)

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Article Rheumatology

Open-label randomised pragmatic trial (CONTACT) comparing naproxen and low-dose colchicine for the treatment of gout flares in primary care

Edward Roddy et al.

ANNALS OF THE RHEUMATIC DISEASES (2020)

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Article Rheumatology

Rare genetic variants in interleukin-37 link this anti-inflammatory cytokine to the pathogenesis and treatment of gout

Viola Kluck et al.

ANNALS OF THE RHEUMATIC DISEASES (2020)

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Article Biochemistry & Molecular Biology

Genomic dissection of 43 serum urate-associated loci provides multiple insights into molecular mechanisms of urate control

James Boocock et al.

HUMAN MOLECULAR GENETICS (2020)

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Review Immunology

Urate-induced immune programming: Consequences for gouty arthritis and hyperuricemia

Georgiana C'abau et al.

IMMUNOLOGICAL REVIEWS (2020)

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Review Rheumatology

T cell metabolism: new insights in systemic lupus erythematosus pathogenesis and therapy

Amir Sharabi et al.

NATURE REVIEWS RHEUMATOLOGY (2020)

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Article Rheumatology

Altered distribution and enhanced osteoclastogenesis of mucosal-associated invariant T cells in gouty arthritis

Young-Nan Cho et al.

RHEUMATOLOGY (2020)

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Article Cell Biology

Synthetic 4-Hydroxy Auxarconjugatin B, a Novel Autophagy Inducer, Attenuates Gouty Inflammation by Inhibiting the NLRP3 Inflammasome

Chih-Yu Hsieh et al.

CELLS (2020)

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Article Immunology

Cytokine Production and NET Formation by Monosodium Urate-Activated Human Neutrophils Involves Early and Late Events, and Requires Upstream TAK1 and Syk

Olga Tatsiy et al.

FRONTIERS IN IMMUNOLOGY (2020)

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Article Rheumatology

2020 American College of Rheumatology Guideline for the Management of Gout

John D. FitzGerald et al.

ARTHRITIS CARE & RESEARCH (2020)

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Article Multidisciplinary Sciences

N-GSDMD trafficking to neutrophil organelles facilitates IL-1β release independently of plasma membrane pores and pyroptosis

Mausita Karmakar et al.

NATURE COMMUNICATIONS (2020)

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Article Multidisciplinary Sciences

CD44 Receptor Mediates Urate Crystal Phagocytosis by Macrophages and Regulates Inflammation in A Murine Peritoneal Model of Acute Gout

Emira Bousoik et al.

SCIENTIFIC REPORTS (2020)

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Review Immunology

TRPV4-A Missing Link Between Mechanosensation and Immunity

Laura Michalick et al.

FRONTIERS IN IMMUNOLOGY (2020)

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Review Cell Biology

Neutrophil Extracellular Traps (NETs) Take the Central Stage in Driving Autoimmune Responses

Esther Fousert et al.

CELLS (2020)

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Review Microbiology

Host-microbiota interactions in immune-mediated diseases

William E. Ruff et al.

NATURE REVIEWS MICROBIOLOGY (2020)

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Review Immunology

The IL-1 family cytokines and receptors in autoimmune diseases

Paola Migliorini et al.

AUTOIMMUNITY REVIEWS (2020)

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Review Rheumatology

Global epidemiology of gout: prevalence, incidence, treatment patterns and risk factors

Mats Dehlin et al.

NATURE REVIEWS RHEUMATOLOGY (2020)

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Review Rheumatology

Gout epidemiology and comorbidities

Jasvinder A. Singh et al.

SEMINARS IN ARTHRITIS AND RHEUMATISM (2020)

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Article Cell Biology

IL-33 enhances macrophage release of IL-1β and promotes pain and inflammation in gouty arthritis

Victor Fattori et al.

INFLAMMATION RESEARCH (2020)

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Article Immunology

Gallic Acid Alleviates Gouty Arthritis by Inhibiting NLRP3 Inflammasome Activation and Pyroptosis Through Enhancing Nrf2 Signaling

Yuqing Lin et al.

FRONTIERS IN IMMUNOLOGY (2020)

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Article Immunology

A Synthetic Small Molecule F240B Decreases NLRP3 Inflammasome Activation by Autophagy Induction

Chun-Hsien Wu et al.

FRONTIERS IN IMMUNOLOGY (2020)

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Article Immunology

Role of T cells in the pathogenesis and treatment of gout

Bin Wang et al.

INTERNATIONAL IMMUNOPHARMACOLOGY (2020)

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Article Medicine, Research & Experimental

IL-33/ST2 induces neutrophil-dependent reactive oxygen species production and mediates gout pain

Chengyu Yin et al.

THERANOSTICS (2020)

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Article Medicine, Research & Experimental

A mouse model of MSU-induced acute inflammation in vivo suggests imiquimod-dependent targeting of Il-1β as relevant therapy for gout patients

Alexandre Mariotte et al.

THERANOSTICS (2020)

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Article Rheumatology

Dapansutrile, an oral selective NLRP3 inflammasome inhibitor, for treatment of gout flares: an open-label, dose-adaptive, proof-of-concept, phase 2a trial

Viola Kluck et al.

LANCET RHEUMATOLOGY (2020)

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Article Immunology

Resveratrol attenuates the MSU crystal-induced inflammatory response through the inhibition of TAK1 activity

Hongmei Li et al.

INTERNATIONAL IMMUNOPHARMACOLOGY (2019)

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Review Biochemistry & Molecular Biology

Interleukin-18 in Health and Disease

Koubun Yasuda et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

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Article Immunology

The Long Pentraxin 3 Contributes to Joint Inflammation in Gout by Facilitating the Phagocytosis of Monosodium Urate Crystals

Nathalia Batista et al.

JOURNAL OF IMMUNOLOGY (2019)

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Article Pharmacology & Pharmacy

Myricetin inhibits NLRP3 inflammasome activation via reduction of ROS-dependent ubiquitination of ASC and promotion of ROS-independent NLRP3 ubiquitination

Hanwen Chen et al.

TOXICOLOGY AND APPLIED PHARMACOLOGY (2019)

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Article Endocrinology & Metabolism

IL-33 Ameliorates the Development of MSU-Induced Inflammation Through Expanding MDSCs-Like Cells

Ke Shang et al.

FRONTIERS IN ENDOCRINOLOGY (2019)

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Article Rheumatology

Sirt1 inhibits gouty arthritis via activating PPARγ

Juan Wang et al.

CLINICAL RHEUMATOLOGY (2019)

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Article Biochemistry & Molecular Biology

Epigallocatechin-3-Gallate Prevents Acute Gout by Suppressing NLRP3 Inflammasome Activation and Mitochondrial DNA Synthesis

Hye Eun Lee et al.

MOLECULES (2019)

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Article Rheumatology

Presence of tophi is a predictive factor of arterial stiffness in patients with gout

WooSeong Jeong et al.

RHEUMATOLOGY INTERNATIONAL (2019)

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Review Immunology

Neutrophil Diversity in Health and Disease

Carlos Silvestre-Roig et al.

TRENDS IN IMMUNOLOGY (2019)

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Article Cell Biology

Propofol directly induces caspase-1-dependent macrophage pyroptosis through the NLRP3-ASC inflammasome

Lingbin Sun et al.

CELL DEATH & DISEASE (2019)

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Article Multidisciplinary Sciences

Glucosamine inhibits IL-1β expression by preserving mitochondrial integrity and disrupting assembly of the NLRP3 inflammasome

Hsiao-Wen Chiu et al.

SCIENTIFIC REPORTS (2019)

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Article Pharmacology & Pharmacy

IL-17A neutralizing antibody regulates monosodium urate crystal-induced gouty inflammation

Federica Raucci et al.

PHARMACOLOGICAL RESEARCH (2019)

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Article Biochemistry & Molecular Biology

Cichorium intybus L. Extract Suppresses Experimental Gout by Inhibiting the NF-κB and NLRP3 Signaling Pathways

Yu Wang et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

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Article Immunology

Caspase-11 Mediates Neutrophil Chemotaxis and Extracellular Trap Formation During Acute Gouty Arthritis Through Alteration of Cofilin Phosphorylation

Kyle Caution et al.

FRONTIERS IN IMMUNOLOGY (2019)

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Article Cell Biology

Mechanistic insight into the attenuation of gouty inflammation by Taiwanese green propolis via inhibition of the NLRP3 inflammasome

Chih-Yu Hsieh et al.

JOURNAL OF CELLULAR PHYSIOLOGY (2019)

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Review Immunology

Overview of the IL-1 family in innate inflammation and acquired immunity

Charles A. Dinarello

IMMUNOLOGICAL REVIEWS (2018)

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Review Immunology

Interleukin-33 (IL-33): A nuclear cytokine from the IL-1 family

Corinne Cayrol et al.

IMMUNOLOGICAL REVIEWS (2018)

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Article Cardiac & Cardiovascular Systems

Roles of PAD4 and NETosis in Experimental Atherosclerosis and Arterial Injury Implications for Superficial Erosion

Gregory Franck et al.

CIRCULATION RESEARCH (2018)

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Article Medicine, Research & Experimental

Tranilast directly targets NLRP3 to treat inflammasome-driven diseases

Yi Huang et al.

EMBO MOLECULAR MEDICINE (2018)

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Article Immunology

The Gasdermin-D pore acts as a conduit for IL-1 secretion in mice

Rosalie Heilig et al.

EUROPEAN JOURNAL OF IMMUNOLOGY (2018)

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Article Biochemistry & Molecular Biology

A novel IgG1 monoclonal antibody against xanthine oxidase alleviates inflammation induced by potassium oxonate in mice

Xiaoran Liu et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2018)

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Article Multidisciplinary Sciences

OLT1177, a ß-sulfonyl nitrile compound, safe in humans, inhibits the NLRP3 inflammasome and reverses the metabolic cost of inflammation

Carlo Marchetti et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2018)

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Article Pharmacology & Pharmacy

Inhibition of COX-2/mPGES-1 and 5-LOX in macrophages by leonurine ameliorates monosodium urate crystal-induced inflammation

Yanzhuo Liu et al.

TOXICOLOGY AND APPLIED PHARMACOLOGY (2018)

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Article Rheumatology

Validation of a Definition of Flare in Patients With Established Gout

Angelo L. Gaffo et al.

ARTHRITIS & RHEUMATOLOGY (2018)

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Article Cell Biology

Changes of Treg/Th17 Ratio in Spleen of Acute Gouty Arthritis Rat Induced by MSU Crystals

Xiao-Juan Dai et al.

INFLAMMATION (2018)

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Article Rheumatology

MicroRNA-302b negatively regulates IL-1β production in response to MSU crystals by targeting IRAK4 and EphA2

Teng Ma et al.

ARTHRITIS RESEARCH & THERAPY (2018)

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Article Rheumatology

NLRP3 inflammasome inhibitor OLT1177 suppresses joint inflammation in murine models of acute arthritis

Carlo Marchetti et al.

ARTHRITIS RESEARCH & THERAPY (2018)

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Review Immunology

Neutrophil extracellular traps in immunity and disease

Venizelos Papayannopoulos

NATURE REVIEWS IMMUNOLOGY (2018)

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Article Cell Biology

Macrophage-derived IL-1β enhances monosodium urate crystal-triggered NET formation

Payel Sil et al.

INFLAMMATION RESEARCH (2017)

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Article Immunology

P2Y6 Receptor Antagonist MRS2578 Inhibits Neutrophil Activation and Aggregated Neutrophil Extracellular Trap Formation Induced by Gout-Associated Monosodium Urate Crystals

Payel Sil et al.

JOURNAL OF IMMUNOLOGY (2017)

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Article Immunology

Berberine, an isoquinoline alkaloid suppresses TXNIP mediated NLRP3 inflammasome activation in MSU crystal stimulated RAW 264.7 macrophages through the upregulation of Nrf2 transcription factor and alleviates MSU crystal induced inflammation in rats

Palani Dinesh et al.

INTERNATIONAL IMMUNOPHARMACOLOGY (2017)

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Article Biochemistry & Molecular Biology

Periodic variation in bile acids controls circadian changes in uric acid via regulation of xanthine oxidase by the orphan nuclear receptor PPAR

Takumi Kanemitsu et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2017)

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Article Immunology

Identification of a selective and direct NLRP3 inhibitor to treat inflammatory disorders

Hua Jiang et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2017)

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Article Medicine, General & Internal

Increased circulating Th22 cells in patients with acute gouty arthritis: A CONSORT-compliant article

Guangcheng Luo et al.

MEDICINE (2017)

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Review Rheumatology

Inflammation in gout: mechanisms and therapeutic targets

Alexander K. So et al.

NATURE REVIEWS RHEUMATOLOGY (2017)

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Article Medicine, General & Internal

The Dietary Approaches to Stop Hypertension (DASH) diet, Western diet, and risk of gout in men: prospective cohort study

Sharan K. Rai et al.

BMJ-BRITISH MEDICAL JOURNAL (2017)

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Article Cell Biology

β-Hydroxybutyrate Deactivates Neutrophil NLRP3 Inflammasome to Relieve Gout Flares

Emily L. Goldberg et al.

CELL REPORTS (2017)

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Article Medicine, General & Internal

The Dietary Approaches to Stop Hypertension (DASH) diet, Western diet, and risk of gout in men: prospective cohort study

Sharan K. Rai et al.

BMJ-BRITISH MEDICAL JOURNAL (2017)

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Article Pharmacology & Pharmacy

C5a Regulates IL-1β Production and Leukocyte Recruitment in a Murine Model of Monosodium Urate Crystal-Induced Peritonitis

Hanif J. Khameneh et al.

FRONTIERS IN PHARMACOLOGY (2017)

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Article Immunology

CD14+ Cells with the Phenotype of Infiltrated Monocytes Consist of Distinct Populations Characterized by Anti-inflammatory as well as Pro-inflammatory Activity in Gouty Arthritis

Ji Hye Jeong et al.

FRONTIERS IN IMMUNOLOGY (2017)

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Article Multidisciplinary Sciences

The tyrosine kinase inhibitor imatinib mesylate suppresses uric acid crystal-induced acute gouty arthritis in mice

Laurent L. Reber et al.

PLOS ONE (2017)

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Article Multidisciplinary Sciences

BOT-4-one attenuates NLRP3 inflammasome activation: NLRP3 alkylation leading to the regulation of its ATPase activity and ubiquitination

Do-Wan Shim et al.

SCIENTIFIC REPORTS (2017)

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Review Immunology

Neutrophil extracellular traps (NETs) in autoimmune diseases: A comprehensive review

Keum Hwa Lee et al.

AUTOIMMUNITY REVIEWS (2017)

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Review Medicine, General & Internal

Impact of comorbidities on gout and hyperuricaemia: an update on prevalence and treatment options

Thomas Bardin et al.

BMC MEDICINE (2017)

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Article Rheumatology

Neutrophil microvesicles resolve gout by inhibiting C5a-mediated priming of the inflammasome

Arun Cumpelik et al.

ANNALS OF THE RHEUMATIC DISEASES (2016)

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Article Rheumatology

IL-37 inhibits the production of pro-inflammatory cytokines in MSU crystal-induced inflammatory response

Mei Zeng et al.

CLINICAL RHEUMATOLOGY (2016)

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Article Immunology

Transmembrane TNF-α is sufficient for articular inflammation and hypernociception in a mouse model of gout

Flavio A. Amaral et al.

EUROPEAN JOURNAL OF IMMUNOLOGY (2016)

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Article Immunology

PMA and crystal-induced neutrophil extracellular trap formation involves RIPK1-RIPK3-MLKL signaling

Jyaysi Desai et al.

EUROPEAN JOURNAL OF IMMUNOLOGY (2016)

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Article Pharmacology & Pharmacy

Mast Cell Stabilizer Ketotifen Inhibits Gouty Inflammation in Rats

Dur-Zong Hsu et al.

AMERICAN JOURNAL OF THERAPEUTICS (2016)

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Article Hematology

Central Role of P2Y6 UDP Receptor in Arteriolar Myogenic Tone

Gilles Kauffenstein et al.

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2016)

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Review Immunology

Cytokine Profile in Gout: Inflammation Driven by IL-6 and IL-18?

Nara Gualberto Cavalcanti et al.

IMMUNOLOGICAL INVESTIGATIONS (2016)

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Article Plant Sciences

Juniperus rigida Sieb. extract inhibits inflammatory responses via attenuation of TRIF-dependent signaling and inflammasome activation

Ji-Won Han et al.

JOURNAL OF ETHNOPHARMACOLOGY (2016)

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Article Cell Biology

Macrophage migration inhibitory factor drives neutrophil accumulation by facilitating IL-1β production in a murine model of acute gout

Izabela Galvao et al.

JOURNAL OF LEUKOCYTE BIOLOGY (2016)

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Review Immunology

Interleukin 1α and the inflammatory process

Nelson C. Di Paolo et al.

NATURE IMMUNOLOGY (2016)

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Letter Biochemistry & Molecular Biology

Neutrophils are not required for resolution of acute gouty arthritis in mice

Laurent L. Reber et al.

NATURE MEDICINE (2016)

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Article Cell Biology

TGF-β and the TGF-β Family: Context-Dependent Roles in Cell and Tissue Physiology

Masato Morikawa et al.

COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY (2016)

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Article Endocrinology & Metabolism

Potential of IL-33 for Preventing the Kidney Injury via Regulating the Lipid Metabolism in Gout Patients

Lihua Duan et al.

JOURNAL OF DIABETES RESEARCH (2016)

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Article Rheumatology

AMP-activated protein kinase suppresses urate crystal-induced inflammation and transduces colchicine effects in macrophages

Yun Wang et al.

ANNALS OF THE RHEUMATIC DISEASES (2016)

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Article Multidisciplinary Sciences

Blood-borne phagocytes internalize urate microaggregates and prevent intravascular NETosis by urate crystals

Elmar Pieterse et al.

SCIENTIFIC REPORTS (2016)

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Article Multidisciplinary Sciences

Targeting ASC in NLRP3 inflammasome by caffeic acid phenethyl ester: a novel strategy to treat acute gout

Hye Eun Lee et al.

SCIENTIFIC REPORTS (2016)

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Article Rheumatology

Interleukin 37 limits monosodium urate crystal-induced innate immune responses in human and murine models of gout

Lei Liu et al.

ARTHRITIS RESEARCH & THERAPY (2016)

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Article Biochemistry & Molecular Biology

Phenotypic, Functional, and Plasticity Features of Classical and Alternatively Activated Human Macrophages

Abdullah A. Tarique et al.

AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY (2015)

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Review Immunology

Initiation and perpetuation of NLRP3 inflammasome activation and assembly

Eric I. Elliott et al.

IMMUNOLOGICAL REVIEWS (2015)

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Article Immunology

Intracellular ATP Decrease Mediates NLRP3 Inflammasome Activation upon Nigericin and Crystal Stimulation

Johji Nomura et al.

JOURNAL OF IMMUNOLOGY (2015)

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Article Multidisciplinary Sciences

SK3 channel and mitochondrial ROS mediate NADPH oxidase-independent NETosis induced by calcium influx

David Nobuhiro Douda et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2015)

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Article Cell Biology

Neutrophil-derived microvesicles enter cartilage and protect the joint in inflammatory arthritis

Sarah E. Headland et al.

SCIENCE TRANSLATIONAL MEDICINE (2015)

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Review Biochemistry & Molecular Biology

Calcium and ROS: A mutual interplay

Agnes Goerlach et al.

REDOX BIOLOGY (2015)

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Article Pharmacology & Pharmacy

Lemnalol attenuates mast cell activation and osteoclast activity in a gouty arthritis model

Hsin-Pai Lee et al.

JOURNAL OF PHARMACY AND PHARMACOLOGY (2015)

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Review Immunology

Origin, development, and homeostasis of tissue-resident macrophages

Malay Haldar et al.

IMMUNOLOGICAL REVIEWS (2014)

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Review Immunology

Macrophage heterogeneity in tissues: phenotypic diversity and functions

Siamon Gordon et al.

IMMUNOLOGICAL REVIEWS (2014)

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Article Biochemistry & Molecular Biology

3,4-Methylenedioxy-β-nitrostyrene Inhibits NLRP3 Inflammasome Activation by Blocking Assembly of the Inflammasome

Yuan He et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2014)

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Article Biochemistry & Molecular Biology

Aggregated neutrophil extracellular traps limit inflammation by degrading cytokines and chemokines

Christine Schauer et al.

NATURE MEDICINE (2014)

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Article Multidisciplinary Sciences

Role of caspase-1 in nuclear translocation of IL-37, release of the cytokine, and IL-37 inhibition of innate immune responses

Ana-Maria Bulau et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)

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Article Rheumatology

Enhanced p62 expression through impaired proteasomal degradation is involved in caspase-1 activation in monosodium urate crystal-induced interleukin-1β expression

Jung-Yoon Choe et al.

RHEUMATOLOGY (2014)

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Article Rheumatology

Contribution of Mast Cell-Derived Interleukin-1β to Uric Acid Crystal-Induced Acute Arthritis in Mice

Laurent L. Reber et al.

ARTHRITIS & RHEUMATOLOGY (2014)

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Article Multidisciplinary Sciences

Therapeutic effects of sesame oil on monosodium urate crystal-induced acute inflammatory response in rats

Dur-Zong Hsu et al.

SPRINGERPLUS (2013)

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Review Immunology

Neutrophil recruitment and function in health and inflammation

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Inflammasome Activators Induce Interleukin-1α Secretion via Distinct Pathways with Differential Requirement for the Protease Function of Caspase-1

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P2Y6 Receptor Signaling Pathway Mediates Inflammatory Responses Induced by Monosodium Urate Crystals

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Inflammasomes in carcinogenesis and anticancer immune responses

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Review Hematology

Interleukin-1 in the pathogenesis and treatment of inflammatory diseases

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Understanding the mechanism of IL-1β secretion

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IL-1α and IL-1β Recruit Different Myeloid Cells and Promote Different Stages of Sterile Inflammation

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Role of TRPV1 in nociception and edema induced by monosodium urate crystals in rats

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Neutrophil Extracellular Trap Formation Is Associated with IL-1β and Autophagy-Related Signaling in Gout

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Article Rheumatology

Engagement of Fatty Acids With Toll-like Receptor 2 Drives Interleukin-1β Production via the ASC/Caspase 1 Pathway in Monosodium Urate Monohydrate Crystal-Induced Gouty Arthritis

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ARTHRITIS AND RHEUMATISM (2010)

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The natural killer cell: a further innate mediator of gouty inflammation?

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Resident Macrophages Initiating and Driving Inflammation in a Monosodium Urate Monohydrate Crystal-Induced Murine Peritoneal Model of Acute Gout

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ARTHRITIS AND RHEUMATISM (2009)

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Review Immunology

Mechanisms of interieukin-1β release

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IMMUNOBIOLOGY (2009)

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Quality of Life and Disability in Patients with Treatment-Failure Gout

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JOURNAL OF RHEUMATOLOGY (2009)

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Extracellular histones are major mediators of death in sepsis

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NATURE MEDICINE (2009)

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TGF-β:: A master of all T cell trades

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Review Biochemistry & Molecular Biology

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Platelet TLR4 activates neutrophil extracellular traps to ensnare bacteria in septic blood

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NATURE MEDICINE (2007)

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Engagement of CD14 mediates the inflammatory potential of monosodium urate crystals

Peter Scott et al.

JOURNAL OF IMMUNOLOGY (2006)

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Article Rheumatology

Innate immunity conferred by toll-like receptors 2 and 4 and myeloid differentiation factor 88 expression is pivotal to monosodium urate monohydrate crystal-induced inflammation

LB Ru et al.

ARTHRITIS AND RHEUMATISM (2005)

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P2Y6 nucleotide receptors activate NF-κB and increase survival of osteoclasts

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JOURNAL OF BIOLOGICAL CHEMISTRY (2005)

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Monosodium urate crystals synergize with IFN-γ to generate macrophage nitric oxide:: Involvement of extracellular signal-regulated kinase 1/2 and NF-κB

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JOURNAL OF IMMUNOLOGY (2004)

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Monosodium urate monohydrate crystal-induced inflammation in vivo -: Quantitative histomorphometric analysis of cellular events

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