Engineering versatile Au-based catalysts for solar-to-fuel conversion

Article Gastroenterology & Hepatology

PBMC transcriptomics identifies immune-metabolism disorder during the development of HBV-ACLF

Jiang Li et al.

Summary: This study suggests that immune-metabolism disorder triggered by HBV exacerbation may be a potential mechanism of HBV-ACLF, providing a novel diagnostic and treatment target to reduce HBV-ACLF-related mortality.

GUT (2022)

添加到收藏夹

Article Genetics & Heredity

A Five-Gene Signature Associated With DNA Damage Repair Molecular Subtype Predict Overall Survival for Hepatocellular Carcinoma

Junyu Huo et al.

Summary: The proposed five-gene risk score in this study may provide new insights into the individualized evaluation of HCC prognosis.

FRONTIERS IN GENETICS (2022)

添加到收藏夹

Article Cardiac & Cardiovascular Systems

Osteopontin promotes infarct repair

Itai Rotem et al.

Summary: Understanding how macrophages promote myocardial repair can help create new therapies for infarct repair. Recombinant osteopontin (OPN) has been found to play a significant role in myocardial healing by stimulating cardiac cell growth, cell-cycle re-entry, and migration. OPN also promotes proliferation and migration of non-cardiomyocytes. In animal models, OPN injection improves scar formation, cardiac function, and left ventricular remodeling. OPN may serve as a promising cell-free therapy for optimizing infarct repair.

BASIC RESEARCH IN CARDIOLOGY (2022)

添加到收藏夹

Review Gastroenterology & Hepatology

Osteopontin Takes Center Stage in Chronic Liver Disease

Zhuolun Song et al.

Summary: Despite being initially discovered in bone, osteopontin (OPN) is expressed in other tissues as well. In addition to its well-established physiological roles, research suggests that OPN is also involved in chronic liver disease.

HEPATOLOGY (2021)

添加到收藏夹

Article Gastroenterology & Hepatology

Assessing the role of amino acids in systemic inflammation and organ failure in patients with ACLF

Giacomo Zaccherini et al.

Summary: In patients with ACLF, metabolite modules increased along with markers of systemic inflammation and oxidative stress. Most proteinogenic amino acids were present and increased. A metabolic network involving amino acids was activated, suggesting increased nucleotide synthesis. Certain compounds involved in antioxidant synthesis were increased. Intermediates of ketogenic amino acids catabolism were increased. Levels of spermidine, an autophagy inducer, were decreased.

JOURNAL OF HEPATOLOGY (2021)

添加到收藏夹

Article Gastroenterology & Hepatology

PREDICT identifies precipitating events associated with the clinical course of acutely decompensated cirrhosis

Jonel Trebicka et al.

Summary: This study analyzed the precipitants leading to acute decompensation in cirrhosis patients, identifying proven bacterial infections and severe alcoholic hepatitis as the main causes. The number of precipitants was significantly associated with 90-day mortality, emphasizing the need for specific preventive and therapeutic strategies targeting these events.

JOURNAL OF HEPATOLOGY (2021)

添加到收藏夹

Article Immunology

Increased Circulating T Follicular Helper Cells Induced via IL-12/21 in Patients With Acute on Chronic Hepatitis B Liver Failure

Bingying Du et al.

Summary: The study found that the frequency of T follicular helper (Tfh) cells significantly increased in HBV-ACLF patients, correlating with MELD score. Additionally, HBV-ACLF patients had higher serum levels of IL-12 and IL-21. Naive CD4(+) T cells from healthy controls differentiated into Tfh cells when exposed to serum from HBV-ACLF patients.

FRONTIERS IN IMMUNOLOGY (2021)

添加到收藏夹

Review Gastroenterology & Hepatology

Acute-on-chronic liver failure: A distinct clinical syndrome

Richard Moreau et al.

Summary: ACLF has different operating definitions in different geographic regions, with Western countries focusing on patients with cirrhosis and Asia focusing on patients with chronic liver diseases. ACLF can be precipitated by different acute insults and defined by different consortia, but all agree that it is a distinct clinical entity.

JOURNAL OF HEPATOLOGY (2021)

添加到收藏夹

Article Gastroenterology & Hepatology