期刊
CHEMICAL COMMUNICATIONS
卷 51, 期 68, 页码 13290-13293出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c5cc03651h
关键词
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资金
- Novartis-MIT Center for Continuous Manufacturing
- NSF [CHE-9808061, DBI-9729592]
An automated, continuous flow droplet screening system is presented, enabling real-time simultaneous solvent and continuous variable optimization. An optimal design of experiments strategy is applied to the alkylation of 1,2-diaminocyclohexane in 16 mu L droplets, with scale-up demonstrated. Analysis of segmented flow results suggests correlation of yield with solvent hydrogen bond basicity.
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