A novel diaqua-bridged water soluble copper(II) complex acts as an efficient cytotoxic agent against lung cancer cells

The present work focuses on the synthesis and characterization of a new water soluble mu-diaqua bridged dinu-clear Cu(II) complex (complex 1) as an efficient chemotherapeutic drug candidate. Complex 1 was thoroughly characterized by various spectral and analytical techniques. DFT studies were employed to determine the HOMO-LUMO energies and electron density localization in the complex 1. The different intermolecular char-acteristics that support the crystal stability in complex 1 were examined by Hirshfeld surface analysis. The corroborative results of DNA binding studies of complex 1 were suggestive of an electrostatic binding mode. Furthermore, in vitro cytotoxicity assessment of complex 1 against A549 and MDA-MB-231 cancer cell lines revealed its efficient and selective cytotoxicity for A549 cancer cell line.

Automated summary

The present work focuses on the synthesis and characterization of a new water soluble dinuclear Cu(II) complex as a potential chemotherapeutic drug. The complex was thoroughly characterized and its intermolecular characteristics and DNA binding mode were investigated. The complex exhibited efficient and selective cytotoxicity against A549 cancer cell line.