Construction of Core-Shell MOF CSMnP with Enzyme-Like Activity for Chemotherapy and Chemodynamic Therapy

Materials with enzyme-like activity have received a lot of attention in the field of tumor catalytic therapy. Here, biocompatible core-shell MOF CSMnP with two valence states of Mn ion, which could process chemodynamic therapy (CDT), was designed and synthesized. Besides, it could also promote a series of catalytic processes in the tumor microenvironment (TME). CSMnP catalyzed endogenous hydrogen peroxide (H2O2) to oxygen (O-2) via catalase-like activity and then combined with the outer layer Mn(II)-PBC to convert O-2 into superoxide radicals (O-center dot(2)-), exhibiting oxidase-like activity. Besides, intracellular glutathione (GSH) could be effectively consumed through the glutathione oxidase-like activity of Mn3+. The occurrence of the cascade reactions effectively amplified the enzymatic production to enhance CDT. Furthermore, the therapeutic effect of CSMnP was improved through the loading of cationic drug DOX. The loading capacity was 11.10 wt %, which was 2.2 times that of Mn(III)-PBC (4.95 wt %), and the release of DOX showed a characteristic response. Therefore, the core-shell MOF with enzyme-like activity had a potential application for tumor combination therapy.

Automated summary

The core-shell MOF CSMnP with enzyme-like activity was designed and synthesized for chemodynamic therapy and promotion of catalytic processes in the tumor microenvironment. The loading capacity of the MOF for the cationic drug DOX was significantly higher than that of Mn(III)-PBC, and the release of DOX showed a characteristic response. It has potential applications for tumor combination therapy.