期刊
MICROBIOLOGY AND IMMUNOLOGY
卷 60, 期 10, 页码 708-711出版社
WILEY
DOI: 10.1111/1348-0421.12440
关键词
autophagy; JEV; p62; SQSTM1
资金
- JSPS KAKENHI [JP25430119]
- Kanazawa Medical University [S2014-6, S2015-1]
The role of the autophagy adaptor protein p62/SQSTM1 in Japanese encephalitis virus (JEV) replication in mouse embryonic fibroblasts (MEFs) was investigated. Amounts of JEV RNA and E protein were significantly smaller in p62-deficient cells than wild-type cells at 24 hr post-infection (p.i.). JEV RNA quantitation and viral plaque assays showed significant reductions in viral titers in p62-deficient cell culture fluid. Our results indicate that JEV replication is impaired in p62-deficient MEFs, suggesting that p62 positively regulates JEV replication in host cells.
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