A fast-responsive mitochondria-targeted fluorescent probe detecting endogenous hypochlorite in living RAW 264.7 cells and nude mouse

A very fast-responsive fluorescent probe PZ-Py for imaging mitochondrial HClO/ClO-, with a relatively long emission wavelength, was prepared. The limit of detection was evaluated to be 17.9 nM. Moreover, the probe PZ-Py was successfully applied in the imaging of endogenous HClO/ClO- in the mitochondria of RAW 264.7 cells and living nude mouse.