Macrophage-derived inflammation promotes pulmonary vascular remodeling in hypoxia-induced pulmonary arterial hypertension mice

Article Cardiac & Cardiovascular Systems

SPARC, a Novel Regulator of Vascular Cell Function in Pulmonary Hypertension

Christine Veith et al.

Summary: This study provides evidence for the involvement of SPARC in the pathogenesis of human PH and chronic hypoxia-induced PH in mice, most likely by affecting vascular cell function.

CIRCULATION (2022)

添加到收藏夹

Review Immunology

Functional Hallmarks of Healthy Macrophage Responses: Their Regulatory Basis and Disease Relevance

Katherine M. Sheu et al.

Summary: This review discusses the importance and functions of macrophages in the immune system. The effector and sentinel functions of healthy macrophages rely on response specificity, context dependence, and stimulus memory. Impairment of these hallmark properties may lead to immune dysregulation.

ANNUAL REVIEW OF IMMUNOLOGY (2022)

添加到收藏夹

Review Medicine, General & Internal

Diagnosis and Treatment of Pulmonary Arterial Hypertension A Review

Nicole F. Ruopp et al.

Summary: Pulmonary arterial hypertension, a subtype of pulmonary hypertension characterized by pulmonary arterial remodeling, can progress to right heart failure and death if left untreated. Approved therapies targeting multiple biological pathways have significantly improved survival rates.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2022)

添加到收藏夹

Article Physiology

Effects of acetazolamide on pulmonary artery pressure and prevention of high-altitude pulmonary edema after rapid active ascent to 4,559 m

Marc Moritz Berger et al.

Summary: Acetazolamide is not recommended for prevention of high-altitude pulmonary edema (HAPE) in mountaineers ascending rapidly to over 4,500 m, despite its ability to alleviate symptoms of acute mountain sickness (AMS) and improve arterial oxygenation.

JOURNAL OF APPLIED PHYSIOLOGY (2022)

添加到收藏夹

Article Critical Care Medicine

Macrophage-NLRP3 Activation Promotes Right Ventricle Failure in Pulmonary Arterial Hypertension

Ruaa Al-Qazazi et al.

Summary: This study evaluates the contribution of NLRP3 inflammasome activation in RV macrophages to PAH RVF. The results show that NLRP3-macrophage activation occurs in both preclinical PAH models and PAH patients. Inhibiting NLRP3 signaling improves RV function, suggesting a new therapeutic paradigm for PAH RVF.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2022)

添加到收藏夹

Review Chemistry, Medicinal

Recent Advances in the Treatment of Pulmonary Arterial Hypertension

Naoyuki Otani et al.

Summary: Pulmonary arterial hypertension (PAH) is a disease that leads to right-sided heart failure and death. Basic research has identified the decrease in levels of endogenous vasodilators and increase in levels of endogenous vasoconstrictors in PAH patients, leading to the development of therapeutic agents. Current treatments target specific pathways to improve prognosis.

PHARMACEUTICALS (2022)

添加到收藏夹

Review Pharmacology & Pharmacy

The role of chemokines and chemokine receptors in pulmonary arterial hypertension

Argen Mamazhakypov et al.

Summary: This review highlights the central role of inflammation in pulmonary arterial hypertension (PAH) and the regulation of chemokines and chemokine receptors in PAH and right ventricular remodeling. Studies have shown that pharmacological targeting of chemokines and receptors could be an effective therapeutic approach for PAH.

BRITISH JOURNAL OF PHARMACOLOGY (2021)

添加到收藏夹

Review Biochemistry & Molecular Biology

Macrophage-derived cytokines in pneumonia: Linking cellular immunology and genetics

Marina Dukhinova et al.

Summary: The formation and balance of cytokine profiles during pneumonia is a hot topic in medical immunology, with the diversity of cytokines determined by variations in cytokine-receptor interactions, which can lead to cytokine storms and functional decline in specific tissues and organs.

CYTOKINE & GROWTH FACTOR REVIEWS (2021)

添加到收藏夹

Review Medicine, General & Internal

Pulmonary Arterial Hypertension

Paul M. Hassoun

NEW ENGLAND JOURNAL OF MEDICINE (2021)

添加到收藏夹

Review Environmental Sciences

Pulmonary Hypertension in Acute and Chronic High Altitude Maladaptation Disorders

Akylbek Sydykov et al.

Summary: Alveolar hypoxia in high altitude environments leads to pulmonary hypertension and potentially life-threatening disorders such as high altitude pulmonary edema. While vasodilators show promise in reducing pulmonary artery pressure in residents at high altitudes, no approved drugs currently exist for treating chronic high altitude pulmonary hypertension.

INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH (2021)

添加到收藏夹

Article Clinical Neurology

Systemic sclerosis-associated myositis features minimal inflammation and characteristic capillary pathology

Elise Siegert et al.

Summary: Systemic sclerosis patients with muscle weakness were found to have a characteristic capillary pathology called minimal myositis with capillary pathology (MMCP) in approximately 67% of cases. This study used large-scale electron microscopy to reveal specific capillary morphology in skeletal muscles, introducing a new level of precision in ultrastructural analysis. The findings suggest a relatively homogeneous clinical picture among MMCP patients, with milder disease and specific patterns of organ involvement.

ACTA NEUROPATHOLOGICA (2021)

添加到收藏夹

Review Chemistry, Multidisciplinary

Cytokines: From Clinical Significance to Quantification

Chao Liu et al.

Summary: Cytokines play a critical role in regulating immune and inflammatory responses, serving as biomarkers for many diseases. Quantification of cytokines provides valuable insights into physiological and pathological processes for diagnosis and treatment in both clinical medicine and biology. Advances in in vitro and in vivo assays, biosensors, and quantification platforms aim to achieve real-time multiplex cytokine analysis for biomedical research and clinical practice.

ADVANCED SCIENCE (2021)

添加到收藏夹

Article Hematology

Altered Macrophage Polarization Induces Experimental Pulmonary Hypertension and Is Observed in Patients With Pulmonary Arterial Hypertension

Amira Zawia et al.

Summary: The study showed that reducing CD68 macrophages globally affects the development of experimental PAH, particularly in male mice. Imbalance of macrophages can lead to changes in the PAH phenotype.

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2021)

添加到收藏夹

Editorial Material Critical Care Medicine

Promising Advances for Imaging Lung Macrophage Recruitment

Delphine L. Chen

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2020)

添加到收藏夹

Article Critical Care Medicine

Risk Reduction and Right Heart Reverse Remodeling by Upfront Triple Combination Therapy in Pulmonary Arterial Hypertension

Michele D'Alto et al.

CHEST (2020)

添加到收藏夹

Review Cardiac & Cardiovascular Systems

Chronic inflammation within the vascular wall in pulmonary arterial hypertension: more than a spectator

Alice Huertas et al.

CARDIOVASCULAR RESEARCH (2020)

添加到收藏夹

Article Respiratory System

Relationship between compliance and pulmonary vascular resistance in pulmonary arterial hypertension

Sarah Guigui et al.

JOURNAL OF THORACIC DISEASE (2020)

添加到收藏夹

Review Cell Biology

Perivascular Inflammation in Pulmonary Arterial Hypertension

Yijie Hu et al.

CELLS (2020)

添加到收藏夹

Review Pharmacology & Pharmacy

Inflammasomes: a novel therapeutic target in pulmonary hypertension?

Tara Elizabeth Scott et al.

BRITISH JOURNAL OF PHARMACOLOGY (2019)

添加到收藏夹

Article Biochemistry & Molecular Biology

Focus on Early Events: Pathogenesis of Pulmonary Arterial Hypertension Development

Olga Rafikova et al.

ANTIOXIDANTS & REDOX SIGNALING (2019)

添加到收藏夹

Review Immunology

Interleukin-33 (IL-33): A nuclear cytokine from the IL-1 family

Corinne Cayrol et al.

IMMUNOLOGICAL REVIEWS (2018)

添加到收藏夹

Article Critical Care Medicine

Endothelial and Smooth Muscle Cell Interaction via FoxM1 Signaling Mediates Vascular Remodeling and Pulmonary Hypertension

Zhiyu Dai et al.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2018)

添加到收藏夹

Article Immunology

The effects of interleukin-33 on airways collagen deposition and matrix metalloproteinase expression in a murine surrogate of asthma

Gao An et al.

IMMUNOLOGY (2018)

添加到收藏夹

Review Cell Biology

Macrophage plasticity, polarization, and function in health and disease

Abbas Shapouri-Moghaddam et al.

JOURNAL OF CELLULAR PHYSIOLOGY (2018)

添加到收藏夹

Editorial Material Medicine, Research & Experimental

Classical IL-6 signaling: a promising therapeutic target for pulmonary arterial hypertension

Soni Savai Pullamsetti et al.

JOURNAL OF CLINICAL INVESTIGATION (2018)

添加到收藏夹

Article Immunology

Inflammatory Macrophage Expansion in Pulmonary Hypertension Depends upon Mobilization of Blood-Borne Monocytes

Jonathan Florentin et al.

JOURNAL OF IMMUNOLOGY (2018)

添加到收藏夹

Article Cell & Tissue Engineering

Early gestational mesenchymal stem cell secretome attenuates experimental bronchopulmonary dysplasia in part via exosome-associated factor TSG-6

Sushma Chaubey et al.

STEM CELL RESEARCH & THERAPY (2018)

添加到收藏夹

Article Medicine, General & Internal

IL-33 Initiates Vascular Remodelling in Hypoxic Pulmonary Hypertension by up-Regulating HIF-1 alpha and VEGF Expression in Vascular Endothelial Cells

Jie Liu et al.

EBIOMEDICINE (2018)

添加到收藏夹

Article Biochemistry & Molecular Biology

Roles for the CX3CL1/CX3CR1 and CCL2/CCR2 Chemokine Systems in Hypoxic Pulmonary Hypertension

Valerie Amsellem et al.

AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY (2017)

添加到收藏夹

Article Critical Care Medicine

Regulatory T Cell Dysfunction in Idiopathic, Heritable and Connective Tissue-Associated Pulmonary Arterial Hypertension

Alice Huertas et al.

CHEST (2016)

添加到收藏夹

Review Biochemistry & Molecular Biology

STAT3 signaling in immunity

Emily J. Hillmer et al.

CYTOKINE & GROWTH FACTOR REVIEWS (2016)

添加到收藏夹

Article Immunology

Nasal administration of interleukin-33 induces airways angiogenesis and expression of multiple angiogenic factors in a murine asthma surrogate

Shan Shan et al.

IMMUNOLOGY (2016)

添加到收藏夹

Review Immunology

Interleukin-33 in health and disease

Foo Yew Liew et al.

NATURE REVIEWS IMMUNOLOGY (2016)

添加到收藏夹

Review Physiology

The role of inflammation in hypoxic pulmonary hypertension: from cellular mechanisms to clinical phenotypes

Steven C. Pugliese et al.

AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY (2015)

添加到收藏夹

Article Critical Care Medicine

The Causal Role of IL-4 and IL-13 in Schistosoma mansoni Pulmonary Hypertension

Rahul Kumar et al.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2015)

添加到收藏夹

Review Cardiac & Cardiovascular Systems

Inflammation and Immunity in the Pathogenesis of Pulmonary Arterial Hypertension

Marlene Rabinovitch et al.

CIRCULATION RESEARCH (2014)

添加到收藏夹

Letter Respiratory System

Proinflammatory cytokine levels are linked to death in pulmonary arterial hypertension

Jean-Luc Cracowski et al.

EUROPEAN RESPIRATORY JOURNAL (2014)

添加到收藏夹

Letter Respiratory System

Cytokines in pulmonary arterial hypertension: consider sensitivity when using multiplex technology

Denis Monneret

EUROPEAN RESPIRATORY JOURNAL (2014)

添加到收藏夹

Editorial Material Respiratory System

Is inflammation a potential therapeutic target in chronic thromboembolic pulmonary hypertension?

Rozenn Quarck et al.

EUROPEAN RESPIRATORY JOURNAL (2014)

添加到收藏夹

Article Cardiac & Cardiovascular Systems

Reliability of Noninvasive Assessment of Systolic Pulmonary Artery Pressure by Doppler Echocardiography Compared to Right Heart Catheterization: Analysis in a Large Patient Population

Sebastian Greiner et al.

JOURNAL OF THE AMERICAN HEART ASSOCIATION (2014)

添加到收藏夹

Article Critical Care Medicine

A Central Role for CD68(+) Macrophages in Hepatopulmonary Syndrome Reversal by Macrophage Depletion

Thenappan Thenappan et al.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2011)

添加到收藏夹

Review Immunology

Phenotypic and functional plasticity of cells of innate immunity: macrophages, mast cells and neutrophils

Stephen J. Galli et al.

NATURE IMMUNOLOGY (2011)

添加到收藏夹

Article Cardiac & Cardiovascular Systems

Fenfluramine-Induced Gene Dysregulation in Human Pulmonary Artery Smooth Muscle and Endothelial Cells

Weijuan Yao et al.

Pulmonary Circulation (2011)

添加到收藏夹

Article Critical Care Medicine

Strategic Plan for Lung Vascular Research An NHLBI-ORDR Workshop Report

Serpil Erzurum et al.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2010)

添加到收藏夹

Article Allergy

Immunologic messenger molecules: Cytokines, interferons, and chemokines

Scott P. Commins et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2010)

添加到收藏夹

Article Immunology

IL-33, an interleukin-1-like cytokine that signals via the IL-1 receptor-related protein ST2 and induces T helper type 2-associated cytokines

J Schmitz et al.

IMMUNITY (2005)

添加到收藏夹

Article Physiology

Decreased alveolar oxygen induces lung inflammation

C Madjdpour et al.

AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY (2003)

添加到收藏夹

Review Multidisciplinary Sciences

Points of control in inflammation

C Nathan

NATURE (2002)

添加到收藏夹

Macrophage-derived inflammation promotes pulmonary vascular remodeling in hypoxia-induced pulmonary arterial hypertension mice

相关参考文献

导出引文

分享论文