期刊
IMMUNOLOGY AND CELL BIOLOGY
卷 -, 期 -, 页码 -出版社
WILEY
DOI: 10.1111/imcb.12676
关键词
cytokine expression; cytotoxicity; functional maturation; granzyme B; NK cells; NOD mice
NK cells are innate immune cells that target infected and tumor cells. mNK cells from NOD mice exhibit a defect in functional maturation and have impaired cytotoxic functions, which is independent of their functional maturation defect. The study shows that the expression of granzyme B is severely impaired in mNK cells from NOD mice, explaining their inability to control tumor growth in vivo. Therefore, phenotypic functional maturation of mNK cells can be uncoupled from the acquisition of cytotoxic functions.
NK cells are innate immune cells that target infected and tumor cells. Mature NK (mNK) cells undergo functional maturation characterized by four distinct stages, during which they acquire their cytotoxic properties. mNK cells from non-obese diabetic (NOD) mice exhibit a defect in functional maturation and have impaired cytotoxic functions. Hence, we tested whether the impaired cytotoxic function observed in mNK cells from NOD mice can be explained by their defect in functional maturation. By comparing the function of mNK cells from B6, B6(g7) and NOD mice, we show that the expression of granzyme B is severely impaired in mNK cells from NOD mice, agreeing with their inability to control tumor growth in vivo. The low level of granzyme B expression in mNK cells from NOD mice is found at all stages of functional maturation and is therefore independent of their functional maturation defect. Consequently, this study demonstrates that phenotypic functional maturation of mNK cells can be uncoupled from the acquisition of cytotoxic functions.
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