☆ 4.6 Review

Challenges and solutions for therapeutic TCR-based agents

IMMUNOLOGICAL REVIEWS (2023)

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Article Biotechnology & Applied Microbiology

Non-viral precision T cell receptor replacement for personalized cell therapy

Susan P. P. Foy et al.

Summary: We used CRISPR-Cas9 non-viral precision genome-editing to knockout the endogenous TCR genes and insert neoantigen-specific TCRs into T cells of cancer patients. This approach demonstrated the feasibility of isolating and cloning multiple TCRs that recognize mutational neoantigens. The gene-edited T cells showed promising results in a phase I clinical trial.

NATURE REVIEWS DRUG DISCOVERY (2023)

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Article Biotechnology & Applied Microbiology

Facile repurposing of peptide-MHC-restricted antibodies for cancer immunotherapy

Xinbo Yang et al.

Summary: This article introduces a strategy for the rapid isolation of highly peptide-specific and "MHC-restricted" antibodies, by re-engineering preselected antibodies that engage peptide-MHC in a manner structurally similar to conventional αβ-TCRs. The authors created structure-based libraries focused on the peptide-interacting residues of TCRm antibody complementarity-determining region (CDR) loops, and rapidly generated MHC-restricted antibodies to both mouse and human tumor antigens. This approach has the potential to yield tumor antigen-specific antibodies in several weeks, enabling rapid clinical translation.

NATURE BIOTECHNOLOGY (2023)

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Article Oncology

A novel antibody-TCR (AbTCR) T-cell therapy is safe and effective against CD19-positive relapsed/refractory B-cell lymphoma

Pengcheng He et al.

Summary: This study provides initial clinical validation of the AbTCR platform as a novel cancer treatment with the potential to provide durable clinical benefit with low toxicity.

JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY (2023)

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Review Hematology

Natural killer T cells and other innate-like T lymphocytes as emerging platforms for allogeneic cancer cell therapy

Amy N. Courtney et al.

Summary: T cells expressing CARs have been successful in treating hematologic malignancies, but not solid cancers. Developing alternative immune cells like NKT cells that can be used in allogeneic settings is important. NKT cells have advantages over T cells and studies have shown their potential in cancer immunotherapy.

BLOOD (2023)

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Article Biochemistry & Molecular Biology

Engineering CAR-T cells to activate small-molecule drugs in situ

Thomas J. Gardner et al.

Summary: CAR-T cell therapy is a significant breakthrough in cancer treatment, but currently limited to B cell cancers. Challenges include resistance from antigen-negative tumor cells, immunosuppression in the tumor microenvironment, and T cell exhaustion. A novel class of CAR-T cells has been developed to activate a systemically administered small-molecule prodrug in situ at a tumor site to enhance anticancer activity.

NATURE CHEMICAL BIOLOGY (2022)

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Article Cell Biology

Targeting an alternate Wilms' tumor antigen 1 peptide bypasses immunoproteasome dependency

Miranda C. Lahman et al.

Summary: Understanding the mechanisms underlying tumor control or resistance is crucial for designing effective antileukemic immunotherapy. This study identified an immune escape mechanism in an AML patient and found that targeting epitopes generated by immunoproteasome-deficient cells can effectively control AML growth, potentially improving therapeutic efficacy.

SCIENCE TRANSLATIONAL MEDICINE (2022)

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Article Hematology

A TCR mimic CAR T cell specific for NDC80 is broadly reactive with solid tumors and hematologic malignancies

Martin G. Klatt et al.

Summary: Mass spectrometry identified a non-immunogenic HLA ligand as a target for CAR T-cell therapy, which showed broad effectiveness against multiple cancer types, particularly hematologic cancers, and had no toxic effects on healthy cells.

BLOOD (2022)

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Article Biochemistry & Molecular Biology

Challenges of the Immunotherapy: Perspectives and Limitations of the Immune Checkpoint Inhibitor Treatment

Paula Dobosz et al.

Summary: This paper reviews recent findings in the field of immunotherapy, with a focus on immune checkpoint inhibitors. The challenges, such as resistance and immune-related adverse events, are discussed, as well as future perspectives on environmental modifiers of immunity and the development of anti-cancer vaccines and combined therapies.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

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News Item Biotechnology & Applied Microbiology

First soluble TCR therapy opens 'new universe' of cancer targets

Elie Dolgin

NATURE BIOTECHNOLOGY (2022)

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Review Biochemistry & Molecular Biology

Engineered cellular immunotherapies in cancer and beyond

Amanda V. Finck et al.

Summary: This Review discusses the goals and challenges of cellular immunotherapy in cancer and outlines strategies to overcome these challenges, highlighting the importance of this field in the treatment of other diseases.

NATURE MEDICINE (2022)

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Article Biochemistry & Molecular Biology

Immunogenicity and therapeutic targeting of a public neoantigen derived from mutated PIK3CA

Smita S. Chandran et al.

Summary: Using a high-throughput platform combining single-cell transcriptomic and T cell receptor sequencing, researchers identified an immunogenic public neoantigen derived from mutant PIK3CA. The study further demonstrated that this neoantigen has therapeutic potential and can induce tumor regression when TCR-engineered T cells are adoptively transferred.

NATURE MEDICINE (2022)

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Article Multidisciplinary Sciences

A TCR mimic monoclonal antibody for the HPV-16 E7-epitope p11-19/HLA-A*02:01 complex

Tao Dao et al.

Summary: Although HPV virus vaccination is available, more effective treatments are needed for HPV-induced cancers. This study discovered TCR mimic monoclonal antibodies that could potentially serve as a therapeutic strategy for HPV-induced human cancers.

PLOS ONE (2022)

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Article Multidisciplinary Sciences

TCR-mimic bispecific antibodies to target the HIV-1 reservoir

Srona Sengupta et al.

Summary: HIV-1 infection is incurable due to the persistence of the virus in a latent reservoir of resting memory CD4(+) T cells. The lack of effective latency-reversing agents and kill strategies has hindered the success of shock-and-kill approaches. This study develops T cell receptor-mimic antibodies that promote killing of infected cells and lays the foundation for a novel therapeutic killing strategy toward elimination of the HIV-1 reservoir.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2022)

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Article Multidisciplinary Sciences

Molecular signatures of antitumor neoantigen-reactive T cells from metastatic human cancers

Frank J. Lowery et al.

Summary: Mapping TCRs from metastatic tumors to single-cell transcriptomes identified tumor-specific expanded neoantigen-specific TILs with dysfunctional phenotypes. Prospectively testing signature-derived clonotypes demonstrated TCR recognition of tumor antigens, suggesting a common metastatic TIL exhaustion program. NeoTCR signatures enable successful TCR prediction for cancer immunotherapy based on TIL transcriptomic states.

SCIENCE (2022)

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Review Immunology

Emerging Strategies in TCR-Engineered T Cells

Fang Wei et al.

Summary: Immunotherapy of cancer, especially TCR-T, has shown remarkable progress in recent years. This review summarizes the challenges and opportunities of TCR-T and proposes a strategy of combining different treatments to target solid tumors effectively.

FRONTIERS IN IMMUNOLOGY (2022)

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Review Immunology

Mechanisms of MHC-I Downregulation and Role in Immunotherapy Response

Brandie C. Taylor et al.

Summary: Immunotherapy is a key strategy in cancer treatment, but understanding and overcoming resistance to it is important. One way tumor cells evade immunosurveillance is by downregulating MHC-I expression. This article reviews current research on MHC-I downregulation and its impact on immunotherapy response, as well as potential strategies to upregulate MHC-I therapeutically.

FRONTIERS IN IMMUNOLOGY (2022)

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Review Immunology

Engineering γδ T Cells: Recognizing and Activating on Their Own Way

Ruoyu Dong et al.

Summary: γδT cells possess both adaptive and innate immune characteristics, enabling them to recognize antigens in a MHC-independent manner. Current designs of engineered γδT cells do not fully utilize their specific characteristics, resulting in limited efficacy in preclinical or clinical trials.

FRONTIERS IN IMMUNOLOGY (2022)

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Review Oncology

To go or not to go? Biological logic gating engineered T cells

Rebecca C. Abbott et al.

Summary: Genetically engineered T cells have been effective in treating hematological malignancies, but not in solid tumors. Biological logic gating in T cells is a promising approach to overcome the challenges associated with solid tumors.

JOURNAL FOR IMMUNOTHERAPY OF CANCER (2022)

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Article Medicine, Research & Experimental

A TCR mimic monoclonal antibody reactive with the public phospho- neoantigen pIRS2/HLA-A*02:01 complex

Tao Dao et al.

Summary: Phosphopeptides derived from dysregulated protein phosphorylation in cancer cells can be processed and presented by MHC class I and class II molecules, making them a potential source of widely expressed tumor-specific antigens. In this study, a TCR mimic antibody specific for a phosphopeptide derived from insulin receptor substrate 2 (pIRS2) presented by HLA-A*02:01 was developed. This antibody successfully recognized the pIRS2/HLA-A2 complex on tumor cell lines and exhibited tumor cell killing ability in a restricted manner. This is the first TCR mimic antibody targeting a phosphopeptide/MHC class I complex, suggesting its potential for clinical applications.

JCI INSIGHT (2022)

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Review Medicine, General & Internal

Adoptive Immunotherapy With Engineered iNKT Cells to Target Cancer Cells and the Suppressive Microenvironment

Gloria Delfanti et al.

Summary: Invariant Natural Killer T (iNKT) cells are a type of lymphocytes that can combat solid and hematological malignancies. They have unique functional features and are attractive for cell immunotherapy. iNKT cells can directly kill cancer cells and suppress immunosuppressive cells in the tumor microenvironment. Moreover, they can be transplanted across MHC barriers without causing alloreaction because of the identical CD1d molecules in all individuals.

FRONTIERS IN MEDICINE (2022)

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Review Biochemistry & Molecular Biology

Joining Forces for Cancer Treatment: From TCR versus CAR to TCR and CAR

Karin Teppert et al.

Summary: This article provides a comprehensive review comparing the architecture, synapse formation, and signaling of TCRs and CARs, highlighting the similarities and differences, as well as the knowns and unknowns. Additionally, the current status of combining CAR and TCR technologies is discussed, advocating a shift in perspective from TCR versus CAR to TCR and CAR.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

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Editorial Material Oncology

Dark genome, bright ideas: Recent approaches to harness transposable elements in immunotherapies

Ashley Reid Cahn et al.

Summary: This article reviews recent progress in understanding the role of transposable elements (TEs) as mediators of immune responses in cancer and discusses how novel therapeutic strategies can utilize TE immunogenicity for cancer immunotherapy.

CANCER CELL (2022)

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Article Medicine, General & Internal

PD-1 Blockade in Mismatch Repair-Deficient, Locally Advanced Rectal Cancer

Andrea Cercek et al.

Summary: This study found that mismatch repair-deficient, locally advanced rectal cancer is highly sensitive to PD-1 blockade. Additionally, no adverse events of grade 3 or higher have been reported, and no cases of progression or recurrence have been observed. Longer follow-up is needed to assess the duration of response.

NEW ENGLAND JOURNAL OF MEDICINE (2022)

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Review Immunology

Gamma Delta T-Cell Based Cancer Immunotherapy: Past-Present-Future

Jose Saura-Esteller et al.

Summary: Gamma delta T-cells can recognize and kill transformed cells independently of HLA-antigen presentation, making them a promising effector cell compartment for cancer immunotherapy. Current research is focused on the V delta 1 and V delta 2 T-cell subtypes, with V delta 1 enriched in tissues and V delta 2 enriched in circulation.

FRONTIERS IN IMMUNOLOGY (2022)

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Review Cell Biology

Application and Design of Switches Used in CAR

Pawel Glowacki et al.

Summary: CAR-T therapy is an exciting treatment for cancer, but its safe application to solid tumors is still a challenge. Scientists have addressed this issue by developing molecular switches to remotely control CAR-T lymphocytes and provide additional functions.

CELLS (2022)

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Article Immunology

TCR-engineered iNKT cells induce robust antitumor response by dual targeting cancer and suppressive myeloid cells

Gloria Delfanti et al.

Summary: Adoptive immunotherapy using T cells engineered with tumor-specific TCRs holds promise for cancer treatment. In this study, researchers harnessed iNKT cells with a second TCR specific for a tumor-associated peptide to generate bispecific effectors for CD1d- and MHC-restricted antigens. The TCR-engineered iNKT cells demonstrated high efficacy in restraining tumor progression and achieved robust cancer control by simultaneously modulating intratumoral suppressive myeloid populations and killing malignant cells. These findings support the potential use of tumor-redirected TCR-iNKT cells and local alpha-GalCer boosting as a therapy for cancer patients.

SCIENCE IMMUNOLOGY (2022)

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Article Immunology

Combination strategies to durably suppress HIV-1: Soluble T cell receptors

Zoe Wallace et al.

Summary: This review discusses the development of ImmTAV molecules as a new therapy for chronic hepatitis B and HIV. These molecules enhance the function of virus-specific T cells, detect and kill infected cells even at low antigen levels, and can target different viral variants.

JOURNAL OF VIRUS ERADICATION (2022)

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Article Oncology

Adoptive Cellular Therapy with Autologous Tumor-Infiltrating Lymphocytes and T-cell Receptor- Engineered T Cells Targeting Common p53 Neoantigens in Human Solid Tumors

Sanghyun P. Kim et al.

Summary: Adoptive cellular therapy (ACT) targeting TP53 mutations shared among different cancer types shows durable clinical responses, but limited efficacy. A library of 39 T-cell receptors (TCRs) targeting shared TP53 mutations in 7.3% of solid tumor patients was reported. Treatment with ex vivo-expanded autologous tumor-infiltrating lymphocytes (TILs) or autologous peripheral blood lymphocytes transduced with an allogeneic HLA-A*02-restricted TCR specific for p53R175H showed improved efficacy.

CANCER IMMUNOLOGY RESEARCH (2022)

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Article Oncology

Inducible localized delivery of an anti-PD-1 scFv enhances anti-tumor activity of ROR1 CAR-T cells in TNBC

Micaela Harrasser et al.

Summary: The research team developed a new generation of ROR1-targeting inducible armored CAR platform, which can release an immune stimulating payload only in the presence of target tumor cells, enhancing the therapeutic activity of CAR-T cells and showing significant survival advantages in TNBC mouse models.

BREAST CANCER RESEARCH (2022)

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Article Gastroenterology & Hepatology

Immunological alterations after immunotherapy with short lived HBV-TCR T cells associates with long-term treatment response in HBV-HCC

Anthony Tanoto Tan et al.

Summary: The study demonstrates the feasibility of using messenger RNA HBV-TCR-redirected T cells for treating patients with HBV-HCC, resulting in long-term clinical benefits. However, further validation is needed to assess the reliability and longevity of immune monitoring.

HEPATOLOGY COMMUNICATIONS (2022)

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Article Biotechnology & Applied Microbiology

Engineered off-the-shelf therapeutic T cells resist host immune rejection

Feiyan Mo et al.

Summary: Engineered T cells targeting allogeneic lymphocytes through the alloimmune defense receptor (ADR) demonstrated effective tumor eradication in mouse models of hematopoietic and solid cancers, offering a potential 'off-the-shelf' therapy for immunocompetent recipients. The ADR selectively recognizes the 4-1BB receptor transiently expressed on activated lymphocytes, allowing for prolonged persistence and therapeutic benefit of rejection-resistant allogeneic T cells. This approach may provide a promising solution to the challenges of manufacturing autologous T cells for cancer therapy.

NATURE BIOTECHNOLOGY (2021)

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Review Immunology

HLA class I loss in colorectal cancer: implications for immune escape and immunotherapy

Per Anderson et al.

Summary: T cell-mediated immune therapies show promise in treating various malignancies, but only a small fraction of patients respond to treatment. Understanding the lack of responses and identifying predictive biomarkers is crucial. CRC is a heterogeneous disease, and the loss of HLA-I in CRC is associated with immune evasion and metastasis.

CELLULAR & MOLECULAR IMMUNOLOGY (2021)

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Meeting Abstract Hematology

Clinical-Scale Production and Characterization of Ntla-5001-a Novel Approach to Manufacturing CRISPR/Cas9 Engineered T Cell Therapies

Daniel Cossette et al.

BLOOD (2021)

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Meeting Abstract Hematology

Allogeneic NKT Cells Expressing a CD19-Specific CAR in Patients with Relapsed or Refractory B-Cell Malignancies: An Interim Analysis

Carlos A. Ramos et al.

BLOOD (2021)

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Review Biochemistry & Molecular Biology

Role of NMR in High Ordered Structure Characterization of Monoclonal Antibodies

Yuji Tokunaga et al.

Summary: The importance of obtaining high ordered structure (HOS) information for the efficacy and safety of monoclonal antibodies (mAbs) is highlighted. Non-invasive and quantitative nuclear magnetic resonance (NMR) spectroscopy is ideal for this purpose, but the high molecular weight of mAbs presents challenges in applying NMR techniques directly. The review discusses the application of NMR techniques, including the recent advances in N-15 direct detection NMR strategy for analyzing mAbs, which can benefit next-generation mAbs.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Article Medicine, Research & Experimental

MAL2 drives immune evasion in breast cancer by suppressing tumor antigen presentation

Yuanzhang Fang et al.

Summary: Immune evasion is a critical event in tumor progression, and downregulation of antigen presentation by tumor cells is a primary mechanism of immune escape. The identification of MAL2 as a key player in enhancing antigen presentation on tumor cells and increasing cytotoxicity of immune cells suggests its potential as a therapeutic target for breast cancer immunotherapy.

JOURNAL OF CLINICAL INVESTIGATION (2021)

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Article Immunology

The SIRPα-CD47 immune checkpoint in NK cells

Tobias Deuse et al.

Summary: The study reveals that disruption of the SIRP alpha-CD47 immune checkpoint may enhance NK cell antitumor responses, and that elevated CD47 expression may prevent NK cell-mediated killing of allogeneic and xenogeneic tissues.

JOURNAL OF EXPERIMENTAL MEDICINE (2021)

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Article Gastroenterology & Hepatology

Immunotherapy of HBV-related advanced hepatocellular carcinoma with short-term HBV-specific TCR expressed T cells: results of dose escalation, phase I trial

Fanping Meng et al.

Summary: The study demonstrates that the adoptive transfer of HBV-specific TCR redirected T cells into advanced HBV-HCC patients is generally safe and well-tolerated, with some clinical efficacy observed. These findings support the continued development and eventual application of this treatment strategy in patients with advanced HBV-related HCC.

HEPATOLOGY INTERNATIONAL (2021)

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Review Oncology

Outlook for New CAR-Based Therapies with a Focus on CAR NK Cells: What Lies Beyond CAR-Engineered T Cells in the Race against Cancer

May Daher et al.

Summary: CAR engineering has transformed the field of cellular therapy for cancer treatment by redirecting the specificity of immune effector cells. The use of natural killer (NK) cells as platforms for CAR engineering has emerged as a safe and effective alternative to traditional CAR-T cells. Expanding this strategy beyond T lymphocytes may lead to safer and more effective off-the-shelf cellular therapy products to combat cancer.

CANCER DISCOVERY (2021)

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Article Biotechnology & Applied Microbiology

CRISPR/Cas9-mediated knockout of clinically relevant alloantigenes in human primary T cells

Elahe Kamali et al.

Summary: CRISPR/Cas9 technology holds great potential in cancer immunotherapy, but genetic knockout in human T cells remains challenging. Knockout through electroporation of CRISPR/Cas9 plasmids is technically feasible, albeit with low efficiency.

BMC BIOTECHNOLOGY (2021)

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Article Immunology

HLA loss of heterozygosity-mediated discordant responses to immune checkpoint blockade in squamous cell lung cancer with renal metastasis

Sheng Yu et al.

Summary: This study reported a case of squamous cell lung carcinoma with renal metastasis treated with pembrolizumab, showing different responses between the primary tumor and rare renal metastases. Loss of heterogeneity in HLA genes and high levels of intratumor heterogeneity were found to impact therapy resistance during tumor evolution, suggesting that they should also be considered during immunotherapy along with tumor mutational burden and PD-L1.

IMMUNOTHERAPY (2021)

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Article Biochemistry & Molecular Biology

TCR-engineered T cells targeting E7 for patients with metastatic HPV-associated epithelial cancers

Nisha B. Nagarsheth et al.

Summary: In a first-in-human phase 1 trial, T cells targeting HPV-16 E7 showed promising results in treating metastatic epithelial cancers, with objective clinical responses observed in 6 out of 12 patients. This suggests that genetically engineered T cell therapy may be effective in treating common carcinomas, but further studies are needed to understand the resistance mechanisms in advanced epithelial cancer.

NATURE MEDICINE (2021)

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Article Multidisciplinary Sciences

Targeting a neoantigen derived from a common TP53 mutation

Emily Han-Chung Hsiue et al.

Summary: An antibody highly specific to the most common TP53 mutation has been identified and converted into an immunotherapeutic agent. Despite low complex density on the cancer cell surface, the bispecific antibody effectively activates T cells to lyse cancer cells expressing the neoantigen. This approach may be used to target cancers with mutations that are difficult to target conventionally.

SCIENCE (2021)

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Review Immunology

Cancer Immune Evasion Through Loss of MHC Class I Antigen Presentation

Karthik Dhatchinamoorthy et al.

Summary: Loss of MHC I antigen presentation is common in many cancers, which may impair immune responses and affect the efficacy of immunotherapy. Studies have discussed underlying mechanisms through which some cancers evade immune killing by shutting down the MHC I pathway, and proposed potential strategies to overcome this limitation.

FRONTIERS IN IMMUNOLOGY (2021)

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Article Immunology

HLA Class I Knockout Converts Allogeneic Primary NK Cells Into Suitable Effectors for Off-the-Shelf Immunotherapy

Keven Hoerster et al.

Summary: The study demonstrates the feasibility of genome editing in primary allogeneic NK cells to reduce their recognition and killing by mismatched T cells, making them potential off-the-shelf immune effectors for immunotherapy in cancer. Genetically engineered NK cells are functionally indistinguishable from unmodified cells with natural cytotoxicity towards AML cell lines.

FRONTIERS IN IMMUNOLOGY (2021)

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Article Immunology

Bispecific antibodies targeting mutant RAS neoantigens

Jacqueline Douglass et al.

Summary: The study isolated specific single-chain variable fragments targeting mutations in the RAS oncogenes. By developing an immunotherapeutic agent capable of killing cancer cells expressing very low levels of RAS-derived antigens, the researchers demonstrated the potential for more specific anticancer therapeutics. The use of CRISPR-mediated alterations provided strong genetic evidence for the specificity of the developed immunotherapeutic agent.

SCIENCE IMMUNOLOGY (2021)

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Review Oncology

The Current Landscape of NKT Cell Immunotherapy and the Hills Ahead

Adam Nelson et al.

Summary: NKT cells are a specialized subset of lipid-reactive T lymphocytes that play direct and indirect roles in immunosurveillance and anti-tumor immunity. Preclinical studies have shown that NKT cell activation via delivery of exogenous glycolipids elicits a significant anti-tumor immune response. This review also examines challenges and future directions for improving the therapy.

CANCERS (2021)

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Review Oncology

CAR-T cell therapy: current limitations and potential strategies

Robert C. Sterner et al.

Summary: CAR-T cell therapy has shown remarkable clinical responses in certain subsets of leukemia or lymphoma, but faces challenges in solid tumors and hematological malignancies. Innovative strategies and approaches are necessary to overcome these challenges and improve the efficacy of CAR-T cells.

BLOOD CANCER JOURNAL (2021)

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Review Immunology

Neoantigen: A New Breakthrough in Tumor Immunotherapy

Zheying Zhang et al.

Summary: Cancer immunotherapy enhances the body's immune response to target and eliminate cancer cells, with a focus on the emerging approach of tumor neoantigens. Studies have shown the relationship between neoantigens and T cell recognition of cancer cells, highlighting the potential of vaccines developed against these specific antigens in clinical trials.

FRONTIERS IN IMMUNOLOGY (2021)

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Article Oncology

Comparison of non-myeloablative lymphodepleting preconditioning regimens in patients undergoing adoptive T cell therapy

Abraham Nissani et al.

Summary: Different non-myeloablative (NMA) regimens using cyclophosphamide or total body irradiation (TBI) combined with fludarabine have varying impacts on bone marrow suppression and recovery, with the 60Cy/125Flu preconditioning appearing to achieve maximum effect with minimum toxicity.

JOURNAL FOR IMMUNOTHERAPY OF CANCER (2021)

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Article Oncology

HLA Ligand Atlas: a benign reference of HLA-presented peptides to improve T-cell-based cancer immunotherapy

Ana Marcu et al.

Summary: This study established the HLA Ligand Atlas, a comprehensive collection of immunopeptidomes from benign human tissue samples, enabling a balanced comparison between tumor and benign tissues. Results showed significant differences in immunopeptidomes between tissues and individuals, with the discovery of peptides from non-canonical genomic regions. This resource is a step towards defining safer tumor-associated targets for T-cell-based immunotherapies.

JOURNAL FOR IMMUNOTHERAPY OF CANCER (2021)

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Article Hematology

Targeting intracellular WT1 in AML with a novel RMF-peptide-MHC-specific T-cell bispecific antibody

Christian Augsberger et al.

Summary: The novel T-cell bispecific (TCB) antibody targets intracellular antigens, recognizing multiple leukemia-associated targets. WT1-TCB demonstrates potent killing of AML cells through various methods, with enhanced cytotoxicity when combined with immunomodulatory drugs.

BLOOD (2021)

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Review Medicine, General & Internal

Perspectives of tumor-infiltrating lymphocyte treatment in solid tumors

Shuhang Wang et al.

Summary: TIL therapy involves harvesting, culturing, and infusing infiltrated lymphocytes from tumors, offering unique advantages in treating solid tumors, yet facing limitations in its current applications.

BMC MEDICINE (2021)

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Article Oncology

Identification and Validation of T-cell Receptors Targeting RAS Hotspot Mutations in Human Cancers for Use in Cell-based Immunotherapy

Noam Levin et al.

Summary: This study identified T-cell receptors that recognize mutated RAS antigens with high specificity and avidity, potentially serving as promising reagents for adoptive cell therapies targeting RAS mutations in cancer patients.

CLINICAL CANCER RESEARCH (2021)

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Article Oncology

Allogeneic CAR Invariant Natural Killer T Cells Exert Potent Antitumor Effects through Host CD8 T-Cell Cross-Priming

Federico Simonetta et al.

Summary: The study assessed the antitumor effects of allogeneic CAR iNKT cells, demonstrating their ability to induce tumor-specific immunity across major MHC barriers and elicit potent antitumor responses from host CD8 T cells. This suggests that the use of off-the-shelf allogeneic CAR iNKT cells could address significant unmet needs in the clinic.

CLINICAL CANCER RESEARCH (2021)

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Letter Oncology

IL-7 and CCL19-secreting CAR-T cell therapy for tumors with positive glypican-3 or mesothelin

Nengzhi Pang et al.

Summary: The study found that engineering human CAR-T cells to secrete human IL-7 and CCL19 (7x19) enhanced expansion and migration capabilities in vitro, and showed superior tumor suppression ability in experimental models compared to conventional CAR-T cells. In clinical trials, the incorporation of 7x19 into CAR-T cells led to significant tumor disappearance in patients with advanced HCC and PC, demonstrating the enhanced antitumor activity against human solid tumors.

JOURNAL OF HEMATOLOGY & ONCOLOGY (2021)

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Review Oncology

T-Cell Receptor Mimic Antibodies for Cancer Immunotherapy

Zhijian Duan et al.

Summary: Antibody-based immunotherapies have shown efficacy in cancer treatment, but their targets are limited. Research has shown that short peptides from intracellular targets could be potential immunotherapy targets. TCRm antibodies are a promising new direction, and future clinical studies will help further understand their mechanisms of action.

MOLECULAR CANCER THERAPEUTICS (2021)

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Editorial Material Biochemistry & Molecular Biology

Immersion in the search for effective cancer immunotherapies

Steven A. Rosenberg

MOLECULAR MEDICINE (2021)

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Article Biotechnology & Applied Microbiology

Incorporation of bacterial immunoevasins to protect cell therapies from host antibody-mediated immune rejection

Leila Peraro et al.

Summary: The use of IgG protease IdeS in programming CAR T cells protects engineered cells from host rejection and enhances the success rate of allogeneic cell therapies. This technology shows promise for repeated human infusions, more complex engineered cells, and expanding the use of off-the-shelf cellular therapies.

MOLECULAR THERAPY (2021)

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Article Medicine, General & Internal

Overall Survival Benefit with Tebentafusp in Metastatic Uveal Melanoma

Paul Nathan et al.

Summary: The randomized trial of tebentafusp for metastatic uveal melanoma showed a higher 1-year overall survival rate among patients who received tebentafusp compared to those who received the investigator's choice of therapy, indicating superior efficacy.

NEW ENGLAND JOURNAL OF MEDICINE (2021)

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Review Oncology

Deregulation of HLA-I in cancer and its central importance for immunotherapy

Ahmet Hazini et al.

Summary: Tumors undergo clonal selection, leading to the expression of tumor antigens in a subset of tumor cells. Immunosurveillance exerts selective pressure by eliminating tumor cells expressing recognized antigens by T cells, and may also select for tumor cells that evade immune detection by acquiring deficiencies in their HLA presentation pathways.

JOURNAL FOR IMMUNOTHERAPY OF CANCER (2021)

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Review Oncology

Therapeutic cancer vaccines

Mansi Saxena et al.

Summary: Therapeutic cancer vaccines aim to induce tumor regression, eradicate minimal residual disease, establish lasting anti-tumor memory, and avoid non-specific or adverse reactions. However, challenges arise due to tumor-induced immunosuppression and immunoresistance, hindering the achievement of these goals.

NATURE REVIEWS CANCER (2021)

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Article Oncology

Somatic HLA Class I Loss Is a Widespread Mechanism of Immune Evasion Which Refines the Use of Tumor Mutational Burden as a Biomarker of Checkpoint Inibitor Response

Meagan Montesion et al.

Summary: The study uncovers the pan-cancer landscape of HLA-I LOH, showing an unexpected relationship between HLA-I LOH and TMB, and demonstrating HLA-I LOH as a significant negative predictor of outcomes after ICI treatment. These findings inform a combined predictor of outcomes after ICI and have implications for tumor vaccine development.

CANCER DISCOVERY (2021)

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Article Biotechnology & Applied Microbiology

Simultaneous Deletion of Endogenous TCRαβ for TCR Gene Therapy Creates an Improved and Safe Cellular Therapeutic

Laura T. Morton et al.

MOLECULAR THERAPY (2020)

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Review Cell Biology

αβ and γδ T cell receptors: Similar but different

Anna Morath et al.

JOURNAL OF LEUKOCYTE BIOLOGY (2020)

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Article Biotechnology & Applied Microbiology

A large peptidome dataset improves HLA class I epitope prediction across most of the human population

Siranush Sarkizova et al.

NATURE BIOTECHNOLOGY (2020)

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Article Immunology

Genome-wide CRISPR-Cas9 screening reveals ubiquitous T cell cancer targeting via the monomorphic MHC class I-related protein MR1

Michael D. Crowther et al.

NATURE IMMUNOLOGY (2020)

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Review Oncology

Engineering strategies to overcome the current roadblocks in CAR T cell therapy

Sarwish Rafiq et al.

NATURE REVIEWS CLINICAL ONCOLOGY (2020)

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Article Multidisciplinary Sciences

Combining DNMT and HDAC6 inhibitors increases anti-tumor immune signaling and decreases tumor burden in ovarian cancer

Sara Moufarrij et al.

SCIENTIFIC REPORTS (2020)

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Article Oncology

Identification of the Targets of T-cell Receptor Therapeutic Agents and Cells by Use of a High-Throughput Genetic Platform

Ron S. Gejman et al.

CANCER IMMUNOLOGY RESEARCH (2020)

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Review Immunology

Regulation of T Helper Cell Fate by TCR Signal Strength

Nayan D. Bhattacharyya et al.

FRONTIERS IN IMMUNOLOGY (2020)

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Article Multidisciplinary Sciences

Oncoprotein SND1 hijacks nascent MHC-I heavy chain to ER-associated degradation, leading to impaired CD8(+) T cell response in tumor

Yuan Wang et al.

SCIENCE ADVANCES (2020)

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Article Multidisciplinary Sciences

Autophagy promotes immune evasion of pancreatic cancer by degrading MHC-I

Keisuke Yamamoto et al.

NATURE (2020)

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Article Immunology

Adoptive cellular therapy with T cells expressing the dendritic cell growth factor Flt3L drives epitope spreading and antitumor immunity

Junyun Lai et al.

NATURE IMMUNOLOGY (2020)

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Article Biochemistry & Molecular Biology

NetMHCpan-4.1 and NetMHCIIpan-4.0: improved predictions of MHC antigen presentation by concurrent motif deconvolution and integration of MS MHC eluted ligand data

Birkir Reynisson et al.

NUCLEIC ACIDS RESEARCH (2020)

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Article Gastroenterology & Hepatology

Immune-Mobilizing Monoclonal T Cell Receptors Mediate Specific and Rapid Elimination of Hepatitis B-Infected Cells

Joannah R. Fergusson et al.

HEPATOLOGY (2020)

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Article Multidisciplinary Sciences

( )Single-cell transcriptomics identifies multiple pathways underlying antitumor function of TCR- and CD8 alpha beta-engineered human CD4(+) T cells

Jan A. Rath et al.

SCIENCE ADVANCES (2020)

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Review Oncology

Targeted Cellular Micropharmacies: Cells Engineered for Localized Drug Delivery

Thomas J. Gardner et al.

CANCERS (2020)

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Review Multidisciplinary Sciences

Strategies for Genetically Engineering Hypoimmunogenic Universal Pluripotent Stem Cells

Wei Zhao et al.

ISCIENCE (2020)

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Article Biochemistry & Molecular Biology

Key Parameters of Tumor Epitope Immunogenicity Revealed Through a Consortium Approach Improve Neoantigen Prediction

Daniel K. Wells et al.

CELL (2020)

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Article Biochemistry & Molecular Biology

A Phase Ib Trial of Personalized Neoantigen Therapy Plus Anti-PD-1 in Patients with Advanced Melanoma, Non-small Cell Lung Cancer, or Bladder Cancer

Patrick A. Ott et al.

CELL (2020)

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Correction Immunology

Cancer immunotherapy with γδ T cells: many paths ahead of us (vol 45, pg 971, 2020)

Dieter Kabelitz et al.

CELLULAR & MOLECULAR IMMUNOLOGY (2020)

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Article Medicine, Research & Experimental

mRNA vaccine-induced neoantigen-specific T cell immunity in patients with gastrointestinal cancer

Gal Cafri et al.

JOURNAL OF CLINICAL INVESTIGATION (2020)

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Review Immunology

Localized Interleukin-12 for Cancer Immunotherapy

Khue G. Nguyen et al.

FRONTIERS IN IMMUNOLOGY (2020)

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Review Immunology

Predicting Cross-Reactivity and Antigen Specificity of T Cell Receptors

Chloe H. Lee et al.

FRONTIERS IN IMMUNOLOGY (2020)

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Article Medicine, Research & Experimental

Solving an MHC allele-specific bias in the reported immunopeptidome

Martin G. Klatt et al.

JCI INSIGHT (2020)

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Article Pharmacology & Pharmacy

Cell-mediated targeting drugs delivery systems

Hongli Yu et al.

DRUG DELIVERY (2020)

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Article Medicine, Research & Experimental

Neoantigen screening identifies broad TP53 mutant immunogenicity in patients with epithelial cancers

Parisa Malekzadeh et al.

JOURNAL OF CLINICAL INVESTIGATION (2019)

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Article Biochemical Research Methods

T cell antigen discovery via signaling and antigen-presenting bifunctional receptors

Alok Joglekar et al.

NATURE METHODS (2019)

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Article Immunology

Engineering antigen-specific NK cell lines against the melanoma-associated antigen tyrosinase via TCR gene transfer

Ayhan Parlar et al.

EUROPEAN JOURNAL OF IMMUNOLOGY (2019)

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Review Cell Biology

Mechanisms of natural killer cell-mediated cellular cytotoxicity

Isabel Prager et al.

JOURNAL OF LEUKOCYTE BIOLOGY (2019)

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Article Multidisciplinary Sciences

Nanobody-based CAR T cells that target the tumor microenvironment inhibit the growth of solid tumors in immunocompetent mice

Yushu Joy Xie et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2019)

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Article Genetics & Heredity

Elevated neoantigen levels in tumors with somatic mutations in the HLA-A, HLA-B, HLA-C and B2M genes

Andrea Castro et al.

BMC MEDICAL GENOMICS (2019)

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Review Oncology

Novel TCR-based biologics: mobilising T cells to warm 'cold' tumours

Kate L. Lowe et al.

CANCER TREATMENT REVIEWS (2019)

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Article Immunology

NK cells switch from granzyme B to death receptor-mediated cytotoxicity during serial killing

Isabel Prager et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2019)

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Article Biotechnology & Applied Microbiology

CAR-T cells secreting BiTEs circumvent antigen escape without detectable toxicity

Bryan D. Choi et al.

NATURE BIOTECHNOLOGY (2019)

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Article Biochemistry & Molecular Biology

T cell receptor gene therapy targeting WT1 prevents acute myeloid leukemia relapse post-transplant

Aude G. Chapuis et al.

NATURE MEDICINE (2019)

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Article Oncology

Unique Neoantigens Arise from Somatic Mutations in Patients with Gastrointestinal Cancers

Maria R. Parkhurst et al.

CANCER DISCOVERY (2019)

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Article Oncology

Intrinsic Resistance to Immune Checkpoint Blockade in a Mismatch Repair-Deficient Colorectal Cancer

Carino Gurjao et al.

CANCER IMMUNOLOGY RESEARCH (2019)

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Review Immunology

Autoreactive T-Lymphocytes in Inflammatory Skin Diseases

Wolf-Henning Boehncke et al.

FRONTIERS IN IMMUNOLOGY (2019)

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Review Biochemistry & Molecular Biology

Clinical Trials with Combination of Cytokine-Induced Killer Cells and Dendritic Cells for Cancer Therapy

Francesca Garofano et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

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Review Oncology

TCR-like antibodies in cancer immunotherapy

Qinghua He et al.

JOURNAL OF HEMATOLOGY & ONCOLOGY (2019)

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Meeting Abstract Hematology

A Phase I Study Evaluating the Safety and Persistence of Allorestricted WT1-TCR Gene Modified Autologous T Cells in Patients with High-Risk Myeloid Malignancies Unsuitable for Allogeneic Stem Cell Transplantation

Emma C. Morris et al.

BLOOD (2019)

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Article Multidisciplinary Sciences

Framework engineering to produce dominant T cell receptors with enhanced antigen-specific function

Sharyn Thomas et al.

NATURE COMMUNICATIONS (2019)

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Article Biochemical Research Methods

Predicting peptide presentation by major histocompatibility complex class I: an improved machine learning approach to the immunopeptidome

Kevin Michael Boehm et al.

BMC BIOINFORMATICS (2019)

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Article Biochemistry & Molecular Biology

The Immune Epitope Database (IEDB): 2018 update

Randi Vita et al.

NUCLEIC ACIDS RESEARCH (2019)

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Article Immunology

A Novel T-Cell Engaging Bi-specific Antibody Targeting the Leukemia Antigen PR1/HLA-A2

Amanda C. Herrmann et al.

FRONTIERS IN IMMUNOLOGY (2019)

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Article Medicine, General & Internal

NK cells specifically TCR-dressed to kill cancer cells

Nadia Mensali et al.

EBIOMEDICINE (2019)

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Article Pathology

Loss of Human Leukocyte Antigen Class I Expression Is Associated with Poor Prognosis in Patients with Advanced Breast Cancer

Hong Sik Park et al.

JOURNAL OF PATHOLOGY AND TRANSLATIONAL MEDICINE (2019)

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Article Multidisciplinary Sciences

Patient HLA class I genotype influences cancer response to checkpoint blockade immunotherapy

Diego Chowell et al.

SCIENCE (2018)

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Article Oncology

CRISPR knock out of programmed cell death protein 1 enhances anti-tumor activity of cytotoxic T lymphocytes

Zhilong Zhao et al.

ONCOTARGET (2018)

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Article Gastroenterology & Hepatology

microRNA 125a Regulates MHC-I Expression on Esophageal Adenocarcinoma Cells, Associated With Suppression of Antitumor Immune Response and Poor Outcomes of Patients

Luigi Mari et al.

GASTROENTEROLOGY (2018)

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Article Gastroenterology & Hepatology

Identification of -fetoprotein-specific T-cell receptors for hepatocellular carcinoma immunotherapy

Wei Zhu et al.

HEPATOLOGY (2018)

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Article Biotechnology & Applied Microbiology

IL-7 and CCL19 expression in CAR-T cells improves immune cell infiltration and CAR-T cell survival in the tumor

Keishi Adachi et al.

NATURE BIOTECHNOLOGY (2018)

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Article Biotechnology & Applied Microbiology

Enhancing T cell therapy through TCR-signaling-responsive nanoparticle drug delivery

Li Tang et al.

NATURE BIOTECHNOLOGY (2018)

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Article Biochemistry & Molecular Biology

Immune recognition of somatic mutations leading to complete durable regression in metastatic breast cancer

Nikolaos Zacharakis et al.

NATURE MEDICINE (2018)

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Article Multidisciplinary Sciences

DNA methyltransferase inhibition upregulates MHC-I to potentiate cytotoxic T lymphocyte responses in breast cancer

Na Luo et al.

NATURE COMMUNICATIONS (2018)

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Review Pathology

New Insights into Graft-Versus-Host Disease and Graft Rejection

Eric Perkey et al.

ANNUAL REVIEW OF PATHOLOGY: MECHANISMS OF DISEASE, VOL 13 (2018)

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Article Oncology

CAR-T Cells Surface-Engineered with Drug-Encapsulated Nanoparticles Can Ameliorate Intratumoral T-cell Hypofunction

Natnaree Siriwon et al.

CANCER IMMUNOLOGY RESEARCH (2018)

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Review Immunology

Engineering Approaches in Human Gamma Delta T Cells for Cancer Immunotherapy

Jonathan Fisher et al.

FRONTIERS IN IMMUNOLOGY (2018)

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Review Immunology

Novel Approaches to Exploiting Invariant NKT Cells in Cancer Immunotherapy

Benjamin J. Wolf et al.

FRONTIERS IN IMMUNOLOGY (2018)

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Article Oncology

CD19 CAR T Cells Expressing IL-12 Eradicate Lymphoma in Fully Lymphoreplete Mice through Induction of Host Immunity

Gray Kueberuwa et al.

MOLECULAR THERAPY-ONCOLYTICS (2018)

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Article Hematology

Antitumor activity of CAR-T cells targeting the intracellular oncoprotein WT1 can be enhanced by vaccination

Yasushi Akahori et al.

BLOOD (2018)

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Article Biotechnology & Applied Microbiology

Targeted delivery of a PD-1-blocking scFv by CAR-T cells enhances anti-tumor efficacy in vivo

Sarwish Rafiq et al.

NATURE BIOTECHNOLOGY (2018)

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Article Biochemistry & Molecular Biology

T cell receptor cross-reactivity expanded by dramatic peptide-MHC adaptability

Timothy P. Riley et al.

NATURE CHEMICAL BIOLOGY (2018)

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Article Multidisciplinary Sciences

Acquired cancer resistance to combination immunotherapy from transcriptional loss of class I HLA

K. G. Paulson et al.

NATURE COMMUNICATIONS (2018)

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Article Oncology

Checkpoint Blockade Reverses Anergy in IL-13Rα2 Humanized scFv-Based CAR T Cells to Treat Murine and Canine Gliomas

Yibo Yin et al.

MOLECULAR THERAPY-ONCOLYTICS (2018)

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Article Cardiac & Cardiovascular Systems

Human Leukocyte Antigen Class I and II Knockout Human Induced Pluripotent Stem Cell-Derived Cells: Universal Donor for Cell Therapy

Saidulu Mattapally et al.

JOURNAL OF THE AMERICAN HEART ASSOCIATION (2018)

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Article Cell Biology

A novel antibody-TCR (AbTCR) platform combines Fab-based antigen recognition with gamma/delta-TCR signaling to facilitate T-cell cytotoxicity with low cytokine release

Yiyang Xu et al.

CELL DISCOVERY (2018)

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Article Medicine, Research & Experimental

TCR-mimic bispecific antibodies targeting LMP2A show potent activity against EBV malignancies

Mahiuddin Ahmed et al.

JCI INSIGHT (2018)

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Article Hematology

Phase 2 trial of a multivalent WT1 peptide vaccine (galinpepimut-S) in acute myeloid leukemia

Peter G. Maslak et al.

BLOOD ADVANCES (2018)

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Article Oncology

Targeting Alpha-Fetoprotein (AFP)-MHC Complex with CART-Cell Therapy for Liver Cancer

Hong Liu et al.

CLINICAL CANCER RESEARCH (2017)

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Article Oncology

Optimized T-cell receptor-mimic chimeric antigen receptor T cells directed toward the intracellular Wilms Tumor 1 antigen

S. Rafiq et al.

LEUKEMIA (2017)

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Article Medicine, Research & Experimental

A therapeutic T cell receptor mimic antibody targets tumor-associated PRAME peptide/HLA-I antigens

Aaron Y. Chang et al.

JOURNAL OF CLINICAL INVESTIGATION (2017)

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Article Multidisciplinary Sciences

Identification of essential genes for cancer immunotherapy

Shashank J. Patel et al.

NATURE (2017)

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Article Biotechnology & Applied Microbiology

HLA-E-expressing pluripotent stem cells escape allogeneic responses and lysis by NK cells

German G. Gornalusse et al.

NATURE BIOTECHNOLOGY (2017)

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Article Multidisciplinary Sciences

Mismatch repair deficiency predicts response of solid tumors to PD-1 blockade

Dung T. Le et al.

SCIENCE (2017)

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Article Multidisciplinary Sciences

Resistance to checkpoint blockade therapy through inactivation of antigen presentation

Moshe Sade-Feldman et al.

NATURE COMMUNICATIONS (2017)

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Review Medicine, Research & Experimental

Leukocyte-mediated Delivery of Nanotherapeutics in Inflammatory and Tumor Sites

Xinyue Dong et al.

THERANOSTICS (2017)

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Article Cell Biology

CAR T Cells Releasing IL-18 Convert to T-Bethigh FoxO1low Effectors that Exhibit Augmented Activity against Advanced Solid Tumors

Markus Chmielewski et al.

CELL REPORTS (2017)

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Review Immunology

Canonical and Non-Canonical Aspects of JAK-STAT Signaling: Lessons from interferons for Cytokine Responses

Andrea Majoros et al.

Frontiers in Immunology (2017)

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Article Multidisciplinary Sciences

Hypoxia and hypoxia-inducible factor (HIF) downregulate antigen-presenting MHC class I molecules limiting tumor cell recognition by T cells

Shalini Sethumadhavan et al.

PLOS ONE (2017)

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Article Oncology

A Randomized Phase II Trial of Adjuvant Galinpepimut-S, WT-1 Analogue Peptide Vaccine, After Multimodality Therapy for Patients with Malignant Pleural Mesothelioma

Marjorie G. Zauderer et al.

CLINICAL CANCER RESEARCH (2017)

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Article Oncology

Enhanced Cancer Immunotherapy by Chimeric Antigen Receptor-Modified T Cells Engineered to Secrete Checkpoint Inhibitors

Si Li et al.

CLINICAL CANCER RESEARCH (2017)

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Article Hematology

Safety and persistence of WT1-specific T-cell receptor gene-transduced lymphocytes in patients with AML and MDS

Isao Tawara et al.

BLOOD (2017)

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Article Oncology

Adoptive Transfer of Invariant NKT Cells as Immunotherapy for Advanced Melanoma: A Phase I Clinical Trial

Mark A. Exley et al.

CLINICAL CANCER RESEARCH (2017)

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Article Hematology

Invariant NKT cells contribute to chronic lymphocytic leukemia surveillance and prognosis

Francesca Gorini et al.

BLOOD (2017)

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Review Oncology

Improving cancer immunotherapy with DNA methyltransferase inhibitors

Mohammad H. Saleh et al.

CANCER IMMUNOLOGY IMMUNOTHERAPY (2016)

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Article Biochemistry & Molecular Biology

Loss of IFN-γ Pathway Genes in Tumor Cells as a Mechanism of Resistance to Anti-CTLA-4 Therapy

Jianjun Gao et al.

CELL (2016)

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Article Biochemistry & Molecular Biology

Engineering T Cells with Customized Therapeutic Response Programs Using Synthetic Notch Receptors

Kole T. Roybal et al.

CELL (2016)

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Review Immunology

Recent advances in viral evasion of the MHC Class I processing pathway

Anouk B. C. Schuren et al.

CURRENT OPINION IN IMMUNOLOGY (2016)

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Article Immunology

Reversed T Cell Receptor Docking on a Major Histocompatibility Class I Complex Limits Involvement in the Immune Response

Stephanie Gras et al.

IMMUNITY (2016)

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Article Biochemistry & Molecular Biology

Structure of a TCR-Mimic Antibody with Target Predicts Pharmacogenetics

Niloufar Ataie et al.

JOURNAL OF MOLECULAR BIOLOGY (2016)

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Article Biotechnology & Applied Microbiology

CD123-Engager T Cells as a Novel Immunotherapeutic for Acute Myeloid Leukemia

Challice L. Bonifant et al.

MOLECULAR THERAPY (2016)

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Article Biochemistry & Molecular Biology

Prospects for gene-engineered T cell immunotherapy for solid cancers

Christopher A. Klebanoff et al.

NATURE MEDICINE (2016)

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Article Medicine, General & Internal

T-Cell Transfer Therapy Targeting Mutant KRAS in Cancer

Eric Tran et al.

NEW ENGLAND JOURNAL OF MEDICINE (2016)

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Article Multidisciplinary Sciences

NLRC5/MHC class I transactivator is a target for immune evasion in cancer

Sayuri Yoshihama et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2016)

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Article Multidisciplinary Sciences

Clonal neoantigens elicit T cell immunoreactivity and sensitivity to immune checkpoint blockade

Nicholas McGranahan et al.

SCIENCE (2016)

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Article Cell Biology

Proteomic screening identifies calreticulin as a miR-27a direct target repressing MHC class I cell surface exposure in colorectal cancer

T. Colangelo et al.

CELL DEATH & DISEASE (2016)

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Article Oncology

Chimeric antigen receptor T cells secreting anti-PD-L1 antibodies more effectively regress renal cell carcinoma in a humanized mouse model

Eloah Rabello Suarez et al.

ONCOTARGET (2016)

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Article Biology

Domain-swapped T cell receptors improve the safety of TCR gene therapy

Michael T. Bethune et al.

ELIFE (2016)

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Article Oncology

Kinase Regulation of Human MHC Class I Molecule Expression on Cancer Cells

Elliott J. Brea et al.

CANCER IMMUNOLOGY RESEARCH (2016)

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Article Multidisciplinary Sciences

T cells expressing CD19-specific Engager Molecules for the Immunotherapy of CD19-positive Malignancies

Mireya Paulina Velasquez et al.

SCIENTIFIC REPORTS (2016)

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Meeting Abstract Hematology

IL-18 Secreting CAR T Cells Enhance Cell Persistence, Induce Prolonged B Cell Aplasia and Eradicate CD19+Tumor Cells without Need for Prior Conditioning

Mauro P. Avanzi et al.

BLOOD (2016)

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Article Pharmacology & Pharmacy

Blinatumomab: First Global Approval

Mark Sanford

DRUGS (2015)

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Article Biochemistry & Molecular Biology

Immunomodulatory action of the DNA methyltransferase inhibitor SGI-110 in epithelial ovarian cancer cells and xenografts

Pragya Srivastava et al.

EPIGENETICS (2015)

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Article Biotechnology & Applied Microbiology

Cytokine-Induced Killer Cells Engineered with Exogenous T-Cell Receptors Directed Against Melanoma Antigens: Enhanced Efficacy of Effector Cells Endowed with a Double Mechanism of Tumor Recognition

Angela R. Elia et al.

HUMAN GENE THERAPY (2015)

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Article Biochemistry & Molecular Biology

Multiple Structural and Epigenetic Defects in the Human Leukocyte Antigen Class I Antigen Presentation Pathway in a Recurrent Metastatic Melanoma Following Immunotherapy

Chien-Chung Chang et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2015)

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Article Gastroenterology & Hepatology

Immunotherapy of HCC metastases with autologous T cell receptor redirected T cells, targeting HBsAg in a liver transplant patient

Waseem Qasim et al.

JOURNAL OF HEPATOLOGY (2015)

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Article Biochemical Research Methods

Mass Spectrometry of Human Leukocyte Antigen Class I Peptidomes Reveals Strong Effects of Protein Abundance and Turnover on Antigen Presentation

Michal Bassani-Sternberg et al.

MOLECULAR & CELLULAR PROTEOMICS (2015)

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Article Biotechnology & Applied Microbiology

Engager T Cells: A New Class of Antigen-specific T Cells That Redirect Bystander T Cells

Kota Iwahori et al.

MOLECULAR THERAPY (2015)

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Article Biotechnology & Applied Microbiology

Therapeutic bispecific T-cell engager antibody targeting the intracellular oncoprotein WT1

Tao Dao et al.

NATURE BIOTECHNOLOGY (2015)

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Article Biochemistry & Molecular Biology

CD47 blockade triggers T cell-mediated destruction of immunogenic tumors

Xiaojuan Liu et al.

NATURE MEDICINE (2015)

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Article Biochemistry & Molecular Biology

Heparanase promotes tumor infiltration and antitumor activity of CAR-redirected T lymphocytes

Ignazio Caruana et al.

NATURE MEDICINE (2015)

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Article Biochemistry & Molecular Biology

NY-ESO-1-specific TCR-engineered T cells mediate sustained antigen-specific antitumor effects in myeloma

Aaron P. Rapoport et al.

NATURE MEDICINE (2015)

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Article Multidisciplinary Sciences

Transfer of mRNA Encoding Invariant NKT Cell Receptors Imparts Glycolipid Specific Responses to T Cells and γδT Cells

Kanako Shimizu et al.

PLOS ONE (2015)

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Review Multidisciplinary Sciences

Adoptive cell transfer as personalized immunotherapy for human cancer

Steven A. Rosenberg et al.

SCIENCE (2015)

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Article Multidisciplinary Sciences

A dendritic cell vaccine increases the breadth and diversity of melanoma neoantigen-specific T cells

Beatriz M. Carreno et al.

SCIENCE (2015)

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Review Cell Biology

Lymphatic system: An active pathway for immune protection

Shan Liao et al.

SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY (2015)

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Review Immunology

Viral immune evasion: Lessons in MHC class I antigen presentation

Michael L. van de Weijer et al.

SEMINARS IN IMMUNOLOGY (2015)

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Review Oncology

Cytokine-induced killer (CIK) cells: from basic research to clinical translation

Yelei Guo et al.

CHINESE JOURNAL OF CANCER (2015)

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Review Immunology

Biology of CD1-and MR1-Restricted T Cells

Mariolina Salio et al.

ANNUAL REVIEW OF IMMUNOLOGY, VOL 32 (2014)

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Review Chemistry, Multidisciplinary

Combinatorial Peptide Libraries: Mining for Cell-Binding Peptides

Bethany Powell Gray et al.

CHEMICAL REVIEWS (2014)

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Article Oncology

Adoptive Transfer of MART-1 T-Cell Receptor Transgenic Lymphocytes and Dendritic Cell Vaccination in Patients with Metastatic Melanoma

Thinle Chodon et al.

CLINICAL CANCER RESEARCH (2014)

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Article Cell & Tissue Engineering

Implication of different effector mechanisms by cord blood-derived and peripheral blood-derived cytokine-induced killer cells to kill precursor B acute lymphoblastic leukemia cell lines

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Tumor-targeted T cells modified to secrete IL-12 eradicate systemic tumors without need for prior conditioning

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An anti-PR1/HLA-A2 T-cell receptor-like antibody mediates complement-dependent cytotoxicity against acute myeloid leukemia progenitor cells

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Tumor-Specific CD8+ T Cells Expressing Interleukin-12 Eradicate Established Cancers in Lymphodepleted Hosts

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TCR Mimic Monoclonal Antibody Targets a Specific Peptide/HLA Class I Complex and Significantly Impedes Tumor Growth In Vivo Using Breast Cancer Models

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Evidence for a TCR Affinity Threshold Delimiting Maximal CD8 T Cell Function

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Hypermethylation of HLA class I gene is associated with HLA class I down-regulation in human gastric cancer

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Induction of Lethal Graft-versus-Host Disease by Anti-CD137 Monoclonal Antibody in Mice Prone to Chronic Graft-versus-Host Disease

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Gene therapy with human and mouse T-cell receptors mediates cancer regression and targets normal tissues expressing cognate antigen

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Affinity-Based Selection of Regulatory T Cells Occurs Independent of Agonist-Mediated Induction of Foxp3 Expression

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Infusion of the allogeneic cell line NK-92 in patients with advanced renal cell cancer or melanoma: a phase I trial

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Adoptive cell therapy for patients with melanoma, using tumor-infiltrating lymphocytes genetically engineered to secrete interleukin-2

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Arthritis induced by posttranslationally modified (citrullinated) fibrinogen in DR4-IE transgenic mice

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Letter Biotechnology & Applied Microbiology

BLOSUM62 miscalculations improve search performance

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Phosphorylation-dependent interaction between antigenic peptides and MHC class I: a molecular basis for the presentation of transformed self

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Association of antigen processing machinery and HLA class I defects with clinicopathological outcome in cervical carcinoma

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GVAX: an allogeneic, whole-cell, GM-CSF-secreting cellular immunotherapy for the treatment of prostate cancer

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Mammalian N-glycan branching protects against innate immune self-recognition and inflammation in autoimmune disease pathogenesis

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Enhanced antitumor activity of T cells engineered to express T-cell receptors with a second disulfide bond

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Extrathymic generation of tumor-specific T cells from genetically engineered human hematopoletic stem cells via notch signaling

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Up-regulation of HLA class-I antigen expression and antigen-specific CTL response in cervical cancer cells by the demethylating agent hydralazine and the histone deacetylase inhibitor valproic acid

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Gene transfer of tumor-reactive TCR confers both high avidity and tumor reactivity to nonreactive peripheral blood mononuclear cells and tumor-infiltrating lymphocytes

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Cancer regression in patients after transfer of genetically engineered lymphocytes

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Isotope-edited IR spectroscopy for the study of membrane proteins

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Enhanced antitumor activity of murine-human hybrid T-cell receptor (TCR) in human lymphocytes is associated with improved pairing and TCR/CD3 stability

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LOH at 6p21.3 region and HLA class I altered phenotypes in bladder carcinomas

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Directed evolution of human T cell receptor CDR2 residues by phage display dramatically enhances affinity for cognate peptide-MHC without increasing apparent cross-reactivity

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αβ T-cell receptor engineered γδ T cells mediate effective antileukemic reactivity

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Natural killer cells produce T cell-recruiting chemokines in response to antibody-coated tumor cells

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CANCER RESEARCH (2006)

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Primary human T lymphocytes engineered with a codon-optimized IL-15 gene resist cytokine withdrawal-induced apoptosis and persist long-term in the absence of exogenous cytokine

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Tumor-targeted, systemic delivery of therapeutic viral vectors using hitchhiking on antigen-specific T cells

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Comparative gene expression profiling of cytokine-induced killer cells in response to acute myloid leukemic and acute lymphoblastic leukemic stimulators using oligonucleotide arrays

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Successful adoptive transfer and in vivo expansion of human haploidentical NK cells in patients with cancer

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BLOOD (2005)

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Defects in the human leukocyte antigen class I antigen-processing machinery in head and neck squamous cell carcinoma: Association with clinical outcome

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Article Biotechnology & Applied Microbiology

Directed evolution of human T-cell receptors with picomolar affinities by phage display

Y Li et al.

NATURE BIOTECHNOLOGY (2005)

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High-affinity, peptide-specific T cell receptors can be generated by mutations in CDR1, CDR2 or CDR3

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A major histocompatibility complex-peptide-restricted antibody and T cell receptor molecules recognize their target by distinct binding modes -: Crystal structure of human leukocyte antigen (HLA)-A1-MAGE-A1 in complex with Fab-Hyb3

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Dissecting cytotoxic T cell responses towards the NY-ESO-1 protein by peptide/MHC-specific antibody fragments

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Autoreactive T cells in healthy individuals

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Reliable prediction of T-cell epitopes using neural networks with novel sequence representations

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Multiple mechanisms generate HLA class I altered phenotypes in laryngeal carcinomas:: high frequency of HLA haplotype loss associated with loss of heterozygosity in chromosome region 6p21

I Maleno et al.

CANCER IMMUNOLOGY IMMUNOTHERAPY (2002)

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Effectiveness of donor natural killer cell alloreactivity in mismatched hematopoietic transplants

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SCIENCE (2002)

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DNA hypermethylation is a mechanism for loss of expression of the HLA class I genes in human esophageal squamous cell carcinomas

Y Nie et al.

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In vitro evolution of a T cell receptor with high affinity for peptide/MHC

PD Holler et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2000)

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Differential tumor surveillance by natural killer (NK) and NKT cells

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JOURNAL OF EXPERIMENTAL MEDICINE (2000)

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