期刊
CHEMICAL COMMUNICATIONS
卷 51, 期 16, 页码 3328-3331出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c4cc09844g
关键词
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资金
- National Natural Science Foundation of China [21172059, 21272059, 21202039, 21372066, 21472037, 21402041]
- National Basic Research Program of China (973 Program) [2014CB560713]
- Program for the Innovative Research Team from the University of Henan Province [2012IRTSTHN006]
- Program for Science & Technology Innovation Talents in Universities of Henan Province [13HASTIT013]
- Doctoral Program of Higher Education of China [20124104110006]
The diversity-oriented synthesis of acyclic nucleosides has been achieved via ring-opening of vinyl cyclopropanes with purines. With Pd-2(dba)(3)center dot CHCl3 as a catalyst, the 1,5-ring-opening reaction proceeded well and afforded N9 adducts as the major form, in which the C=C bonds in the side chain were exclusively E-form. In the presence of AlCl3, the 1,3-ring-opening reaction occurred smoothly, giving N9 adducts as the dominate products. Meanwhile, when MgI2 was used as the catalyst, the 1,3-ring-opening reaction also worked well to form N7 adducts.
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