期刊
MICROBES AND INFECTION
卷 18, 期 9, 页码 559-564出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.micinf.2016.05.002
关键词
Acinetobacter baumannii; Acinetobacter pittii; Adherence; Cytotoxicity; Epithelial cells
资金
- Instituto de Salud Carlos III, Spain [PI13/01310]
- Plan Nacional de I+D+i
- Instituto de Salud Carlos III, Subdireccion General de Redes y Centros de Investigacion Cooperativa, Ministerio de Economia y Competitividad, Spanish Network for Research in Infectious Diseases - European Development Regional Fund [REIPI RD12/0015]
The molecular and genetic basis of Acinetobacter baumannii and Acinetobacter pittii virulence remains poorly understood, and there is still lack of knowledge in host cell response to these bacteria. In this study, we have used eleven clinical Acinetobacter strains (A. baumannii n = 5; A. pittii n = 6) to unravel bacterial adherence, invasion and cytotoxicity to human lung epithelial cells. Our results showed that adherence to epithelial cells by Acinetobacter strains is scarce and cellular invasion was not truly detected. In addition, all Acinetobacter strains failed to induce any cytotoxic effect on A549 cells. (C) 2016 Institut Pasteur. Published by Elsevier Masson SAS. All rights reserved.
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