期刊
METHODS
卷 109, 期 -, 页码 158-166出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.ymeth.2016.06.025
关键词
Photodynamic therapy; Singlet oxygen; Hydroxyl radical; Singlet oxygen sensor green; Hydroxyphenyl fluorescein; Fullerenes; Bacteriochlorins; Phenothiazinium salts
资金
- US NIH [R01AI050875]
Photodynamic therapy involves the excitation of a non-toxic dye by harmless visible light to produce a long-lived triplet state that can interact with molecular oxygen to produce reactive oxygen species (ROS), which can damage biomolecules and kill cells. ROS produced by electron transfer (Type 1) include superoxide, hydrogen peroxide and hydroxyl radical (Ha), while singlet oxygen (O-1(2)) is produced by energy transfer. Diverse methods exist to distinguish between these two pathways, some of which are more specific or more sensitive than others. In this review we cover the use of two fluorescence probes: singlet oxygen sensor green (SOSG) detects O-1(2); and 4-hydroxyphenyl-fluorescein (HPF) that detects Ha. Interesting data was collected concerning the photochemical pathways of functionalized fullerenes compared to tetrapyrroles, stable synthetic bacteriochlorins with and without central metals, phenothiazinium dyes interacting with inorganic salts such as azide. (C) 2016 Elsevier Inc. All rights reserved.
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