Epigenetic Clock: Future of Hypertension Prediction?

Article Biology

DunedinPACE, a DNA methylation biomarker of the pace of aging

Daniel W. Belsky et al.

Summary: This study reports a novel blood biomarker of aging called DunedinPACE, which was validated in five datasets. Results showed that DunedinPACE is associated with morbidity, disability, and mortality, and provides incremental prediction beyond the GrimAge clock. This finding is significant for gerontology and geroscience research.

ELIFE (2022)

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Article Biochemical Research Methods

Comprehensive assessment of cellular senescence in the tumor microenvironment

Xiaoman Wang et al.

Summary: This study quantified cellular senescence levels using computational metrics and explored senescence-related phenotypes in different cancer types and normal tissues. The research found that the cellular senescence scores were associated with genomic and immune characteristics and could significantly predict immunotherapy responses and patient prognosis in various cancers. Single-cell analysis revealed intra-tumor heterogeneity and an activated immune microenvironment in senescent prostate cancer. Machine learning algorithms identified three potential prognostic genes for prostate cancer.

BRIEFINGS IN BIOINFORMATICS (2022)

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Review Genetics & Heredity

Measuring biological age using omics data

Jarod Rutledge et al.

Summary: Age is a significant risk factor for diseases and disabilities in the elderly. Efforts to address age-related health issues require measures of biological age and the rate of aging at the molecular level. Recent advances in high-throughput omics technologies have provided tools to quantify aging at the molecular level and identify new biomarkers of biological aging through machine learning.

NATURE REVIEWS GENETICS (2022)

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Article Cardiac & Cardiovascular Systems

Sex differences in arterial hypertension A scientific statement from the ESC Council on Hypertension, the European Association of Preventive Cardiology, Association of Cardiovascular Nursing and Allied Professions, the ESC Council for Cardiology Practice, and the ESC Working Group on Cardiovascular Pharmacotherapy

Eva Gerdts et al.

Summary: Sex chromosomes and sex hormones play differential roles in blood pressure regulation and cardiovascular risk factors between females and males with essential arterial hypertension. The risk for cardiovascular disease is higher in females at lower blood pressure levels, suggesting the need for sex-specific thresholds in hypertension diagnosis. It is currently unknown if hypertension should be managed differently in females and males, highlighting the need for focused research on sex-specific prevention and management.

EUROPEAN HEART JOURNAL (2022)

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Review Biochemistry & Molecular Biology

How Are Epigenetic Modifications Related to Cardiovascular Disease in Older Adults?

Mojgan Gharipour et al.

Summary: Epigenetic modifications, influenced by lifestyle and environmental factors, play a significant role in gene expression and cellular function. A healthy lifestyle, including a balanced diet, regular exercise, and stress management, is essential in preventing cardiovascular dysfunction associated with epigenetic changes.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Editorial Material Peripheral Vascular Disease