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Article
Pathology
Gregory A. Hosler et al.
Summary: The diagnosis of melanocytic lesions can be aided by ancillary testing, but clinical inspection and histomorphological assessment on biopsy are usually sufficient. Immunohistochemistry and molecular studies can help reduce the number of borderline lesions, and sequential testing may improve diagnostic performance.
Article
Pathology
Christine J. Ko et al.
Summary: Cognitive bias refers to reproducible traps and pitfalls in human thinking patterns that are not intentionally discriminatory but necessary for interpreting the world around us, including microscopic slides. Therefore, examining cognitive bias in pathology, such as dermatopathology, is a useful exercise.
Review
Pathology
Julianna Martel et al.
Summary: Immune checkpoint inhibitors are a promising treatment option for cancer, but their off-target effects can cause immune-related cutaneous adverse events. Accurate diagnosis is crucial for timely and appropriate management.
Review
Pathology
Ashley Patton et al.
Summary: This review provides a comprehensive summary of diverse myoepithelial neoplasms, including those with myoepithelial-like and chondroid histomorphology, as well as mimics that are challenging to distinguish for diagnostic purposes. The clinicopathologic, immunophenotypic, and molecular features of each entity are described.
Article
Pathology
Ryan C. Decoste et al.
Summary: Merkel cell carcinoma is a rare primary cutaneous neuroendocrine carcinoma with adverse prognosis. Advances in understanding its biology, including classification based on different origins, relevance of immunohistochemistry and molecular characteristics, and the use of immunotherapeutics, are discussed in this review. The topics are particularly relevant to surgical and dermatopathologists.
Article
Pathology
Haiming Tang et al.
Summary: This paper reviews recent genetic studies, emphasizing on potential truncal mutations in actinic keratosis, squamous cell carcinoma in situ, cutaneous squamous cell carcinoma, keratoacanthoma, and keratoacanthoma-like squamous proliferation.
Article
Pathology
Katharina Wiedemeyer et al.
Summary: This article reviews the clinical, histopathological, immunohistochemical, and molecular features of dedifferentiated melanoma and provides a practical diagnostic approach and discussion of relevant differential diagnoses and associated diagnostic pitfalls.
Article
Pathology
Fangyi Xie et al.
Summary: Pathologists play a vital role in the dermatological care of pregnant patients. This article provides updates on dermatopathology related to pregnancy, covering various skin changes, specific dermatoses, modified dermatoses, and skin neoplasms. Pathologists' awareness of the impact of pregnancy on the skin is important for diagnostic precision in this patient population.
Article
Pathology
Leah Antoinette Caro-Chang et al.
Summary: Eosinophils are present in inflammatory skin diseases and can serve as indicators for certain diseases. Different skin diseases show varied characteristics in terms of lesional eosinophils.
Article
Pathology
Kyle A. Williams et al.
Summary: Skin of color is a rising area of importance in dermatology, but it remains understudied and under taught. This review aims to discuss the differences in histology of skin of color, highlight the histopathology of conditions more common in these populations, and address potential bias that may affect accurate dermatopathology sign out.
Article
Pathology
Dylan Haynes et al.
Summary: This article reviews the cutaneous toxicities resulting from targeted cancer therapies and their histopathologic characteristics, highlighting the importance of clinical and histopathologic recognition for patient care.
Article
Pathology
Eleni Ieremia et al.
Summary: Scalp biopsies for the diagnosis of alopecia are usually assessed histopathologically in specialist centers. However, in non-specialist settings or at a low frequency, follicular counts and ratios can be a useful diagnostic tool, especially for non-scarring alopecia and those with overlapping features.
Article
Pathology
Rama Godse et al.
Summary: Histopathologic evaluation of the nail unit is crucial for the diagnosis of nail disorders. This review provides updates on nail unit histopathology and discusses literature on various nail disorders, including melanoma, squamous cell carcinoma, onychomatricoma, and more. In addition, the paper also explores the recent literature on nail clipping histopathology as a useful and non-invasive diagnostic tool.
Review
Oncology
Thet Su Win et al.
Summary: While cutaneous melanoma has received much attention in genomic research, other nonmelanoma skin cancers such as basal cell carcinoma and cutaneous squamous cell carcinoma have also been analyzed. This review discusses the latest knowledge on the molecular pathways and therapeutic opportunities for these keratinocytic skin cancers.
Review
Pathology
Devon E. McMahon et al.
Summary: This article aims to characterize the clinical and histopathologic features of emerging infectious diseases with cutaneous manifestations, in order to increase awareness of these diseases.
Article
Dermatology
Aubriana M. McEvoy et al.
Summary: This study aimed to estimate the risk of stage-specific MCC recurrence and mortality since diagnosis. The study included 618 MCC patients enrolled in a Seattle-based data repository from 2003 to 2019. The results showed a 5-year recurrence rate of 40% for MCC, with 95% of recurrences occurring within the first 3 years.
Review
Biochemistry & Molecular Biology
Hye-Young Min et al.
Summary: Molecular targeted therapy has become a fundamental approach in precision medicine for cancer treatment, offering efficient anticancer effects with fewer side effects. However, drug resistance remains a major drawback that needs to be overcome to improve therapeutic efficacy.
EXPERIMENTAL AND MOLECULAR MEDICINE
(2022)
Review
Pathology
Abbas Agaimy et al.
Summary: Dedifferentiated melanoma and undifferentiated melanoma are rare types of melanoma with high phenotypic plasticity, often overlooked by general surgical pathologists. Major clues for the diagnosis of these diseases include medical history, histological appearance, and specific gene mutations.
AMERICAN JOURNAL OF SURGICAL PATHOLOGY
(2021)
Article
Pathology
Cody S. Carter et al.
Article
Hematology
Rein Willemze et al.
Review
Oncology
Drew M. Pardoll
NATURE REVIEWS CANCER
(2012)
Article
Multidisciplinary Sciences
Kate E. Jones et al.
Article
Pathology
DB Troxel
AMERICAN JOURNAL OF SURGICAL PATHOLOGY
(2003)
