期刊
HUMAN PATHOLOGY
卷 139, 期 -, 页码 65-72出版社
W B SAUNDERS CO-ELSEVIER INC
DOI: 10.1016/j.humpath.2023.07.001
关键词
Human papillomavirus; Penile squamous cell carcinoma; Basaloid carcinoma; Warty carcinoma; Warty-basaloid carcinoma
类别
This study evaluated different types of penile carcinoma and found variations in the genotypic composition of HPV based on their histological subtypes. HPV16 was the most common genotype, followed by HPV33 and HPV35. The current vaccination programs can cover 93% of the cases based on the identified genotypes. HPV16 was significantly more frequent in basaloid carcinomas and less frequent in warty carcinomas.
Rating: 8/10
Human papillomavirus (HPV) is detected in 30-50% of invasive penile carcinomas, and it is frequently associated with basaloid and warty morphological features. Based on this heterogeneity and different clinical behaviors, we hypothesized a variation in their HPV genotypic composition. To test this, we evaluated 177 HPV-positive cases: basaloid (114), warty-basaloid (28), and warty (condylomatous) (35) invasive carcinomas. HPV DNA detection and genotyping was performed using the SPF-10/ DEIA/LiPA25 system. Nineteen HPV genotypes were detected. High-risk HPVs predominated (96%), and low-risk HPVs were rarely present. Most common genotype was HPV16 followed by HPVs 33 and 35. According to the genotypes identified, 93% of the cases would be covered with current vaccination programs. There was a significant variation in the distribution of HPV16 and non-HPV16 genotypes according to histological subtype. HPV16 was significantly frequent in basaloid (87%) and was less frequent in warty carcinomas (61%). This molecular difference, along with their distinctive macro -microscopic and prognostic features, makes basaloid and warty carcinomas unique. The gradual decreasing frequency of HPV16 demonstrated in basaloid, warty-basaloid, and warty carcinomas suggest that the basaloid cell, present in those types in decreasing proportions, may be responsible for the differences. (c) 2023 Elsevier Inc. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据