期刊
METHODS
卷 99, 期 -, 页码 37-43出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.ymeth.2015.08.013
关键词
Neural stem cell; Cancer therapy; Drug delivery; Glioblastoma; Gene therapy
资金
- UNC Lineberger Comprehensive Cancer Center's University Cancer Research Fund
- UNC Translational and Clinical Sciences Institute [KL2TR001109, UL1TR001111]
Cancers of the brain remain one of the greatest medical challenges. Traditional surgery and chemoradiation therapy are unable to eradicate diffuse cancer cells and tumor recurrence is nearly inevitable. In contrast to traditional regenerative medicine applications, engineered neural stem cells (NSCs) are emerging as a promising new therapeutic strategy for cancer therapy. The tumor-homing properties allow NSCs to access both primary and invasive tumor foci, creating a novel delivery platform. NSCs engineered with a wide array of cytotoxic agents have been found to significantly reduce tumor volumes and markedly extend survival in preclinical models. With the recent launch of new clinical trials, the potential to successfully manage cancer in human patients with cytotoxic NSC therapy is moving closer to becoming a reality. (C) 2015 Published by Elsevier Inc.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据