New tricks for old molecules: A newly discovered modality for CAMs may yet lead to an HBV cure

Article Gastroenterology & Hepatology

Safety and efficacy of vebicorvir in virologically suppressed patients with chronic hepatitis B virus infection

Man-Fung Yuen et al.

Summary: This study evaluated the efficacy and safety of the investigational core inhibitor, vebicorvir (VBR), in virologically-suppressed patients on NrtIs. Results showed potential enhanced viral suppression with the addition of VBR to NrtIs in certain patient populations.

JOURNAL OF HEPATOLOGY (2022)

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Article Gastroenterology & Hepatology

Combination treatments including the small-interfering RNA JNJ-3989 induce rapid and sometimes prolonged viral responses in patients with CHB

Man-Fung Yuen et al.

Summary: This study assessed the safety and efficacy of JNJ-3989 in combination with nucleos(t)ide analogues for the treatment of patients with chronic hepatitis B. The results demonstrated that JNJ-3989 treatment reduced HBsAg levels in patients and sustained the reduction even 336 days after cessation of treatment.

JOURNAL OF HEPATOLOGY (2022)

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Article Chemistry, Multidisciplinary

Multiscale Modeling of Hepatitis B Virus Capsid Assembly and Its Dimorphism

Farzaneh Mohajerani et al.

Summary: In this study, computer simulations and analysis were used to reveal the assembly process of hepatitis B virus (HBV) and the mechanism of capsid polymorphism. The findings are important for understanding the HBV lifecycle and developing new antiviral drugs.

ACS NANO (2022)

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Editorial Material Gastroenterology & Hepatology

Nomenclature of HBV core protein-targeting antivirals

Fabien Zoulim et al.

Summary: This article proposes a naming convention for HBV core protein-targeting antiviral products to accelerate the development of drugs for Hepatitis B virus.

NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY (2022)

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Article Gastroenterology & Hepatology

Mitosis of hepatitis B virus-infected cells in vitro results in uninfected daughter cells

Thomas Tu et al.

Summary: Using in vitro models, the study found that after cell mitosis, there was a significant reduction in cccDNA levels, HBV-positive cell numbers, and cccDNA-dependent protein expression, supporting the efficacy of inducing cell mitosis to overcome HBV persistence.

JHEP REPORTS (2022)

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Article Biochemistry & Molecular Biology