4.5 Review

Relationship between the aortic root and the atrioventricular conduction axis

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Summary: Despite years of research, many details of the formation of the atrioventricular conduction axis remain uncertain. This study aimed to clarify the situation by studying serial histological sections and datasets of human embryos. The findings revealed the origin and development of the conduction axis, shedding light on how it forms from the primary interventricular ring and undergoes subsequent remodelling processes.

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Summary: Transcatheter aortic valve replacement (TAVR) is a safe alternative to surgery for patients with severe aortic stenosis, but conduction abnormalities requiring permanent pacemaker (PPM) implantation after the procedure are common and need to be carefully monitored. Research suggests that pre-existing conduction abnormalities may increase the risk of PPM implantation and mortality after TAVR.

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