A nickel-mediated oxidative alpha-C(sp(3))-H functionalization of amides with allylic alcohols terminated by radical 1,2-aryl migration

A Ni-mediated oxidative C(sp(3))-H functionalization of N,N-substituted amides with alpha,alpha-diaryl allylic alcohols through a radical 1,2-aryl migration process has been developed. This process features a broad substrate scope and excellent functional group tolerance. Notably, gamma-amino ketones containing an all-carbon quaternary center were synthesized under these conditions in moderate to good yields.