☆ 4.1 Article

Comprehensive analysis of m6A modifications in oral squamous cell carcinoma by MeRIP sequencing

GENES & GENETIC SYSTEMS (2023)

相关参考文献

注意：仅列出部分参考文献，下载原文获取全部文献信息。

Article Biochemistry & Molecular Biology

CNN6mA: Interpretable neural network model based on position-specific CNN and cross-interactive network for 6mA site prediction

Sho Tsukiyama et al.

Summary: N6-methyladenine (6mA) plays crucial roles in various epigenetic processes and diseases. To understand these mechanisms, researchers have developed a CNN-based 6mA site predictor, CNN6mA, which outperforms existing models and provides intelligible interpretation of the prediction mechanism through new architectures.

COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL (2023)

添加到收藏夹

Article Biochemistry & Molecular Biology

As a Novel Tumor Suppressor, LHPP Promotes Apoptosis by Inhibiting the PI3K/AKT Signaling Pathway in Oral Squamous Cell Carcinoma

Shanshan Liu et al.

Summary: Oral squamous cell carcinoma (OSCC) is a common malignant tumor of the head and neck with a poor prognosis and unsatisfactory treatment. This study found that the protein histidine phosphatase LHPP plays an important role in the development of OSCC. LHPP inhibits the growth and migration of OSCC by decreasing the activity of the PI3K/AKT signaling pathway and promoting apoptosis.

INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES (2022)

添加到收藏夹

Article Oncology

Downregulation of m(6)A writer complex member METTL14 in bladder urothelial carcinoma suppresses tumor aggressiveness

Catarina Guimaraes-Teixeira et al.

Summary: The study reveals that the expression levels of m(6)A and its related proteins are lower in bladder cancer. Knockdown of METTL14 reduces the abundance of m(6)A and decreases tumor aggressiveness, suggesting the significant role of m(6)A in bladder cancer progression.

MOLECULAR ONCOLOGY (2022)

添加到收藏夹

Article Genetics & Heredity

MiR-654-3p Constrains Proliferation, Invasion, and Migration of Sinonasal Squamous Cell Carcinoma via CREB1/PSEN1 Regulatory Axis

Xiao Cui et al.

Summary: MiR-654-3p inhibits the malignant progression of SNSCC by targeting CREB1.

FRONTIERS IN GENETICS (2022)

添加到收藏夹

Article Oncology

Agrin Promotes Non-Small Cell Lung Cancer Progression and Stimulates Regulatory T Cells via Increasing IL-6 Secretion Through PI3K/AKT Pathway

Linzhi Han et al.

Summary: The study examined the effects and mechanisms of Agrin in non-small cell lung cancer (NSCLC) and the tumor immune microenvironment. It was found that Agrin promotes tumor cell growth and infiltration of regulatory T cells (Tregs) by increasing IL-6 expression and secretion through the PI3K/AKT pathway. Knockdown of Agrin can suppress the proliferation and metastasis of NSCLC cells.

FRONTIERS IN ONCOLOGY (2022)

添加到收藏夹

Article Cell Biology

Downregulation of ZC3H13 by miR-362-3p/miR-425-5p is associated with a poor prognosis and adverse outcomes in hepatocellular carcinoma

Shuang Wu et al.

Summary: This study identifies ZC3H13 as a potential tumor suppressor gene in hepatocellular carcinoma (HCC) and reveals the miR-362-3p/miR-425-5p-ZC3H13 axis as a regulatory pathway. The expression of ZC3H13 is closely associated with the prognosis and tumor immune infiltration in HCC.

AGING-US (2022)

添加到收藏夹

Article Biochemical Research Methods

BERT6mA: prediction of DNA N6-methyladenine site using deep learning-based approaches

Sho Tsukiyama et al.

Summary: In this study, a novel approach called BERT6mA was proposed for detecting the 6mA modification in DNA, and its performance was evaluated and compared. Through pretraining and fine-tuning, BERT6mA showed high performance in prediction and achieved good results even in species with small sample sizes. Furthermore, the study analyzed the process of feature extraction by the BERT6mA model.

BRIEFINGS IN BIOINFORMATICS (2022)

添加到收藏夹

Article Oncology

ebv-circRPMS1 promotes the progression of EBV-associated gastric carcinoma via Sam68-dependent activation of METTL3

Jing-yue Zhang et al.

Summary: This study found that highly expressed ebv-circRPMS1 in EBVaGC can promote the proliferation, migration, and invasion of cancer cells, and inhibit apoptosis, while METTL3 was upregulated. Mechanistically, ebv-circRPMS1 can bind to Sam68 to facilitate its interaction with the METTL3 promotor, resulting in the transactivation of METTL3.

CANCER LETTERS (2022)

添加到收藏夹

Article Oncology

Therapeutic targeting m6A-guided miR-146a-5p signaling contributes to the melittin-induced selective suppression of bladder cancer

Rucheng Yan et al.

Summary: Abnormal RNA methylation and dysregulation of miRNA are common in bladder cancer, and melittin has shown potential as a drug candidate for intravesical chemotherapy against bladder cancer. METTL3 has been identified as a key regulator in controlling bladder cancer cells' sensitivity to melittin-induced apoptosis, while miR-146a-5p suppression contributes to the selective antitumor effect of melittin.

CANCER LETTERS (2022)

添加到收藏夹

Article Oncology

Anti-HIV Drug Elvitegravir Suppresses Cancer Metastasis via Increased Proteasomal Degradation of m6A Methyltransferase METTL3

Long Liao et al.

Summary: This study reveals the role of METTL3 in promoting cancer metastasis in esophageal squamous cell carcinoma and suggests that targeting METTL3 could be a therapeutic strategy for this type of cancer.

CANCER RESEARCH (2022)

添加到收藏夹

Article Biochemistry & Molecular Biology

RNA demethylase ALKBH5 inhibits TGF-β-induced EMT by regulating TGF-β/SMAD signaling in non-small cell lung cancer

Zelong Sun et al.

Summary: ALKBH5 plays a key role in regulating TGF-beta/SMAD signaling and controlling TGF-beta-induced EMT in NSCLCs. ALKBH5 expression is significantly reduced in metastatic NSCLC and its overexpression inhibits TGF-beta-induced EMT and invasion of NSCLC cells. ALKBH5 affects the expression and mRNA stability of TGF beta R2, SMAD3, and SMAD6 by erasing m(6)A modification in NSCLC cells, and interacts with m(6)A-binding proteins to further regulate TGF-beta signaling.

FASEB JOURNAL (2022)

添加到收藏夹

Article Biochemistry & Molecular Biology

M6A-mediated upregulation of circMDK promotes tumorigenesis and acts as a nanotherapeutic target in hepatocellular carcinoma

Ashuai Du et al.

Summary: This study identified a new oncogenic circRNA, circMDK, that promotes the progression of HCC through the regulation of the miR-346/874-3p-ATG16L1 axis. The research team also developed poly (beta-amino esters)-based nanoparticles that effectively deliver siRNA targeting circMDK, inhibiting HCC proliferation and metastasis.

MOLECULAR CANCER (2022)

添加到收藏夹

Article Biochemistry & Molecular Biology

Tumor-associated macrophage-derived chemokine CCL5 facilitates the progression and immunosuppressive tumor microenvironment of clear cell renal cell carcinoma

Wenhao Xu et al.

Summary: This study first revealed the predictive value of chemokine CCL5 in the progression and tumor microenvironment of ccRCC. Different prognostic clusters and immune phenotypes associated with CCL5 expression were identified, providing new strategies for the treatment of ccRCC.

INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES (2022)

添加到收藏夹

Article Biochemistry & Molecular Biology

Comprehensive analysis of the transcriptome-wide m6A methylome in colorectal cancer by MeRIP sequencing

Zhen Zhang et al.

Summary: Accumulating evidence suggests that m6A modifications play crucial roles in colorectal cancer (CRC) by regulating genes involved in glucose metabolism, RNA metabolism, and cancer stem cells. Dysregulated m6A peaks in CRC samples are associated with tumour progression and patient survival, highlighting the potential of modulating m6A modifications as a strategy for predicting survival and interfering with tumour progression in cancer patients.

EPIGENETICS (2021)

添加到收藏夹

Article Dentistry, Oral Surgery & Medicine

RGS12 Represses Oral Cancer via the Phosphorylation and SUMOylation of PTEN

C. Fu et al.

Summary: Oral squamous cell carcinoma (OSCC) is a common head and neck cancer characterized by aggressive invasion and metastasis, with the pathogenesis primarily attributed to genetic alterations in epithelial cells. The regulator of G protein signaling 12 (RGS12) plays a significant role in OSCC development, acting through interactions with phosphatase and tension homolog (PTEN) to regulate cell signaling pathways, indicating its potential therapeutic value in treating OSCC.

JOURNAL OF DENTAL RESEARCH (2021)

添加到收藏夹

Article Oncology

N6-Methyladenosine Methyltransferase METTL14-Mediated Autophagy in Malignant Development of Oral Squamous Cell Carcinoma

Fang Wang et al.

Summary: The study demonstrates that METTL14 mediates eIF4G1 expression through m(6)A modification, influencing autophagy levels and biological functions in OSCC cells.

FRONTIERS IN ONCOLOGY (2021)

添加到收藏夹

Article Multidisciplinary Sciences

Disruption of the HER3-PI3K-mTOR oncogenic signaling axis and PD-1 blockade as a multimodal precision immunotherapy in head and neck cancer

Zhiyong Wang et al.

Summary: The study suggests that HER3 inhibition can enhance the response to PD-1 blockade in HNSCC patients and may provide a multimodal precision immunotherapeutic approach for treating PIK3CA wild-type HNSCC.

NATURE COMMUNICATIONS (2021)

添加到收藏夹

Article Oncology

Improving function of cytotoxic T-lymphocytes by transforming growth factor-β inhibitor in oral squamous cell carcinoma

Yutaro Kondo et al.

Summary: Immunotherapy with immune-checkpoint therapy for OSCCs is limited by the immunosuppressive effects of TGF-beta, which inhibits CTL function; TGF-beta inhibitor effectively restores CTL function and is primarily expressed at the tumor invasive front; TGFB1 mRNA expression is significantly negatively correlated with the CD8(+) T-cell/Treg ratio and Ki-67 expression in CD8(+) T-cells, indicating TGF-beta suppresses CTL function in situ.

CANCER SCIENCE (2021)

添加到收藏夹

Article Oncology

Joint analysis of lncRNA m6A methylome and lncRNA/mRNA expression profiles in gastric cancer

Zhi Lv et al.

CANCER CELL INTERNATIONAL (2020)

添加到收藏夹

Article Biochemistry & Molecular Biology

Deoxycholic acid modulates the progression of gallbladder cancer through N6-methyladenosine-dependent microRNA maturation

Ruirong Lin et al.

ONCOGENE (2020)

添加到收藏夹

Article Multidisciplinary Sciences

Increased expression of PD-1 and PD-L1 in oral lesions progressing to oral squamous cell carcinoma: a pilot study

Kanan Dave et al.

SCIENTIFIC REPORTS (2020)

添加到收藏夹

Article Biochemistry & Molecular Biology

Effects of IGF-1 on Proliferation, Angiogenesis, Tumor Stem Cell Populations and Activation of AKT and Hedgehog Pathways in Oral Squamous Cell Carcinoma

Jessica Mariane Ferreira Mendes et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

添加到收藏夹

Review Medicine, Research & Experimental

The role of m6A RNA methylation in cancer

Ting Sun et al.

BIOMEDICINE & PHARMACOTHERAPY (2019)

添加到收藏夹

Article Biotechnology & Applied Microbiology

KIAA1429 regulates the migration and invasion of hepatocellular carcinoma by altering m6A modification of ID2 mRNA

Xiaoyu Cheng et al.

ONCOTARGETS AND THERAPY (2019)

添加到收藏夹

Review Physiology

Salivary Biomarkers for Oral Squamous Cell Carcinoma Diagnosis and Follow-Up: Current Status and Perspectives

Marta Cristaldi et al.

FRONTIERS IN PHYSIOLOGY (2019)

添加到收藏夹

Article Biochemical Research Methods

fastp: an ultra-fast all-in-one FASTQ preprocessor

Shifu Chen et al.

BIOINFORMATICS (2018)

添加到收藏夹

Article Medicine, Research & Experimental

ZNF750 inhibited the malignant progression of oral squamous cell carcinoma by regulating tumor vascular microenvironment

Li Pan et al.

BIOMEDICINE & PHARMACOTHERAPY (2018)

添加到收藏夹

Article Multidisciplinary Sciences

The SMAD2/3 interactome reveals that TGFβ controls m6A mRNA methylation in pluripotency

Alessandro Bertero et al.

NATURE (2018)

添加到收藏夹

Review Biochemistry & Molecular Biology

The Dominant Role of Forkhead Box Proteins in Cancer

Duc-Hiep Bach et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2018)

添加到收藏夹

Review Physiology

An Overview on Current Non-invasive Diagnostic Devices in Oral Oncology

Marco Mascitti et al.

FRONTIERS IN PHYSIOLOGY (2018)

添加到收藏夹

Article Multidisciplinary Sciences

Bacterial alterations in salivary microbiota and their association in oral cancer

Wei-Hsiang Lee et al.

SCIENTIFIC REPORTS (2017)

添加到收藏夹

Review Medicine, Research & Experimental

The PI3K/AKT Pathway as a Target for Cancer Treatment

Ingrid A. Mayer et al.

ANNUAL REVIEW OF MEDICINE, VOL 67 (2016)

添加到收藏夹

Article Medicine, Research & Experimental

miR-194 regulated AGK and inhibited cell proliferation of oral squamous cell carcinoma by reducing PI3K-Akt-FoxO3a signaling

Hongyu Chi

BIOMEDICINE & PHARMACOTHERAPY (2015)

添加到收藏夹

Review Oncology

Targeting the PI3K/AKT/mTOR pathway in squamous cell carcinoma of the head and neck

Daniel R. Simpson et al.

ORAL ONCOLOGY (2015)

添加到收藏夹

Article Clinical Neurology

Survival Patterns in Squamous Cell Carcinoma of the Head and Neck: Pain as an Independent Prognostic Factor for Survival

Cielito C. Reyes-Gibby et al.

JOURNAL OF PAIN (2014)

添加到收藏夹

Article Biochemical Research Methods

A protocol for RNA methylation differential analysis with MeRIP-Seq data and exomePeak R/Bioconductor package

Jia Meng et al.

METHODS (2014)

添加到收藏夹

Article Oncology

Up-Regulation of FOXM1 by E6 Oncoprotein through the MZF1/NKX2-1 Axis Is Required for Human Papillomavirus-Associated Tumorigenesis

Po-Ming Chen et al.

NEOPLASIA (2014)

添加到收藏夹

Review Oncology

Forkhead box proteins: tuning forks for transcriptional harmony

Eric W. -F. Lam et al.

NATURE REVIEWS CANCER (2013)

添加到收藏夹

Article Biochemistry & Molecular Biology

Comprehensive Analysis of mRNA Methylation Reveals Enrichment in 3′ UTRs and near Stop Codons

Kate D. Meyer et al.

CELL (2012)

添加到收藏夹

Article Multidisciplinary Sciences

Topology of the human and mouse m6A RNA methylomes revealed by m6A-seq

Dan Dominissini et al.

NATURE (2012)

添加到收藏夹

Review Immunology

Does the PI3K pathway promote or antagonize regulatory T cell development and function?

Dalya R. Soond et al.

FRONTIERS IN IMMUNOLOGY (2012)

添加到收藏夹

Article Immunology

Protein Kinase B Controls Transcriptional Programs that Direct Cytotoxic T Cell Fate but Is Dispensable for T Cell Metabolism

Andrew N. Macintyre et al.

IMMUNITY (2011)

添加到收藏夹

Article Biotechnology & Applied Microbiology

Gene ontology analysis for RNA-seq: accounting for selection bias

Matthew D. Young et al.

GENOME BIOLOGY (2010)

添加到收藏夹

Review Pathology

PTEN and the PI3-Kinase Pathway in Cancer

Nader Chalhoub et al.

ANNUAL REVIEW OF PATHOLOGY-MECHANISMS OF DISEASE (2009)

添加到收藏夹

Review Cell Biology

Messenger-RNA-binding proteins and the messages they carry

G Dreyfuss et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2002)

添加到收藏夹

Review Biochemistry & Molecular Biology

Oxidative stress, human genetic variation, and disease

L Forsberg et al.

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS (2001)

添加到收藏夹

Article Immunology

Pivotal role of phosphoinositide-3 kinase in regulation of cytotoxicity in natural killer cells

K Jiang et al.

NATURE IMMUNOLOGY (2000)

添加到收藏夹

Article Biochemistry & Molecular Biology

KEGG: Kyoto Encyclopedia of Genes and Genomes

M Kanehisa et al.

NUCLEIC ACIDS RESEARCH (2000)

添加到收藏夹

© Peeref 2019-2024. All rights reserved.