期刊
GENES & DEVELOPMENT
卷 37, 期 11-12, 页码 454-473出版社
COLD SPRING HARBOR LAB PRESS, PUBLICATIONS DEPT
DOI: 10.1101/gad.350759.123
关键词
adipocyte; adipose tissue; circadian clock; circadian rhythms; metabolism; transcription; thermogenesis; inflammation; plasticity
In this article, the authors focus on the new insights into the plasticity of adipocytes and the circadian control of adipose tissue metabolism, transcription, and inflammation. They also discuss the recent studies that uncover the mechanistic links between clocks and adipocyte metabolism, as well as its application to dietary and behavioral interventions for improving health and mitigating obesity. The circadian clock plays a crucial role in coordinating feeding and metabolic rhythms, and disrupting the clock is associated with increased adiposity and metabolic disorders.
In this review, Hepler and Bass focus on new insights into adipocyte cellular plasticity as well as circadian control of adipose tissue metabolism, transcription, and inflammation. They also discuss emerging studies uncovering the mechanistic links between clocks and adipocyte metabolism, and its application to dietary and behavioral interventions to improve health and mitigate obesity. The circadian clock plays an essential role in coordinating feeding and metabolic rhythms with the light/dark cycle. Disruption of clocks is associated with increased adiposity and metabolic disorders, whereas aligning feeding time with cell-autonomous rhythms in metabolism improves health. Here, we provide a comprehensive overview of recent literature in adipose tissue biology as well as our understanding of molecular mechanisms underlying the circadian regulation of transcription, metabolism, and inflammation in adipose tissue. We highlight recent efforts to uncover the mechanistic links between clocks and adipocyte metabolism, as well as its application to dietary and behavioral interventions to improve health and mitigate obesity.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据