期刊
FUTURE ONCOLOGY
卷 19, 期 24, 页码 1695-1708出版社
FUTURE MEDICINE LTD
DOI: 10.2217/fon-2023-0361
关键词
diarrhoea; disease-free survival; early-stage breast cancer; extended adjuvant therapy; HER2+; neratinib; toxicity; trastuzumab; tyrosine kinase receptor inhibitors
类别
Neratinib, used after adjuvant trastuzumab therapy, significantly improves disease-free survival in early-stage HER2+ breast cancer without increased risk of long-term toxicity. Diarrhea, the most common adverse event associated with neratinib, can be managed with dose-escalation and prophylactic strategies, allowing treatment continuation.
Neratinib is a tyrosine kinase receptor inhibitor used in the extended adjuvant therapy of early-stage breast cancer. After adjuvant trastuzumab therapy, neratinib reduces the risk of recurrence and, if taken within 1 year from trastuzumab, significantly improves the invasive disease-free survival of patients with early-stage human epidermal growth factor receptor-2 positive (HER2+) breast cancer with no increased risk of long-term toxicity. Diarrhea, the most common adverse event associated with neratinib use, deters some clinicians from prescribing this drug. However, neratinib-related toxicity is predictable, short-lived, mostly limited to the first month of treatment and can be managed with dose-escalation and prophylactic strategies. Thus, close surveillance and prompt management, relying on supportive care and administration schedule modification, allows discontinuation of treatment to be avoided. Tweetable abstractNeratinib, administered within 1 year of trastuzumab, significantly improves disease-free survival in early-stage HER2+ breast cancer, with no increased risk of long-term toxicity. #neratinib #HER2+BC
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