siRNA-based approaches for castration-resistant prostate cancer therapy targeting the androgen receptor signaling pathway

Editorial Material Biotechnology & Applied Microbiology

2022 FDA approvals

Asher Mullard

Summary: In 2022, the FDA approved 37 new drugs, the lowest number to pass regulatory scrutiny since 2016.

NATURE REVIEWS DRUG DISCOVERY (2023)

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Review Oncology

Metastatic Prostate Cancer-A Review of Current Treatment Options and Promising New Approaches

Philip Posdzich et al.

Summary: Prostate cancer is the most common tumor in men and metastatic castration resistant prostate cancer remains a deadly disease despite new developments. This article provides an overview of current and new treatment options, including androgen deprivation therapy (ADT), combination therapies, chemotherapy, ARSI, PARP inhibitors, Lu-PSMA radioligand therapy, and bispecific T-cell engagers (BiTE). The role of immunotherapy in prostate cancer is still being investigated, but overall, the field of prostate cancer therapy is challenging and promising.

CANCERS (2023)

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Review Oncology

The positive relationship between androgen receptor splice variant-7 expression and the risk of castration-resistant prostate cancer: A cumulative analysis

Shankun Zhao et al.

Summary: Androgen receptor splice variant-7 (AR-V7) expression was significantly higher in castration-resistant prostate cancer (CRPC) patients compared to hormone-sensitive prostate cancer (HSPC) patients, according to a systematic review and cumulative analysis.

FRONTIERS IN ONCOLOGY (2023)

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Article Immunology

Strong immune responses and protection of PcrV and OprF-I mRNA vaccine candidates against Pseudomonas aeruginosa

Xingyun Wang et al.

Summary: This study constructed two mRNA vaccines encoding key components of Pseudomonas, PcrV, and fusion protein OprF-I. Immunization with these mRNA vaccines elicited an immune response, reducing disease and inflammation caused by PA infection. mRNA-PcrV vaccine showed stronger immune response and higher survival rate, and the combination of mRNA-PcrV and mRNA-OprF-I had the best effect. These results suggest that mRNA-PcrV and the combination of mRNA-PcrV and mRNA-OprF-I are promising vaccine candidates for the prevention of PA infection.

NPJ VACCINES (2023)

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Review Pharmacology & Pharmacy

Clinical Pharmacology of RNA Interference-Based Therapeutics: A Summary Based on Food and Drug Administration-Approved Small Interfering RNAs

Xing Jing et al.

Summary: RNA-based oligonucleotide therapeutics are revolutionizing drug development for disease treatment, with unique mechanisms of action and clinical pharmacology characteristics. The FDA has published a survey summarizing clinical pharmacology studies on oligonucleotide therapies. This review examines and summarizes clinical pharmacology data of FDA-approved siRNA therapeutics from 2018 to 2022.

DRUG METABOLISM AND DISPOSITION (2023)

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Article Biochemistry & Molecular Biology

DKK1-targeting cholesterol-modified siRNA implication in hair growth regulation

Dimitri Papukashvili et al.

Summary: Despite advancements in medical research, androgenetic alopecia (AGA) still lacks an ideal treatment. This study suggests that targeting dickkopf-related protein 1 (DKK1) with small interfering RNA (siRNA) may promote hair growth regulation in the AGA population by activating the Wnt/I3-catenin signaling pathway. The results showed that DKK1-targeting siRNA had comparable efficacy to the FDA-approved minoxidil topical solution.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2023)

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Review Biochemistry & Molecular Biology

Where should siRNAs go: applicable organs for siRNA drugs

Insook Ahn et al.

EXPERIMENTAL AND MOLECULAR MEDICINE (2023)

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Article Oncology

Loading of cocktail siRNAs into extracellular vesicles via TAT-DRBD peptide for the treatment of castration-resistant prostate cancer

Yanjun Diao et al.

Summary: Extracellular vesicles (EVs) are natural carriers for intercellular communication. In this study, a novel strategy using polycationic membrane-penetrating peptide TAT was used to encapsulate siRNAs into EVs. The successful delivery of siRNA was confirmed, and the potential of TAT as an efficient siRNA carrier was demonstrated.

CANCER BIOLOGY & THERAPY (2022)

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Article Chemistry, Multidisciplinary

Preferential siRNA delivery to injured kidneys for combination treatment of acute kidney injury

Weimin Tang et al.

Summary: This study introduces a siRNA carrier designed for injured kidneys in AKI, showing potential to enhance therapeutic effects and improve kidney function. By inhibiting CXCR4 and p53 simultaneously, the PCX/sip53 polyplexes can selectively deliver therapeutic siRNA in AKI, reducing renal damage.

JOURNAL OF CONTROLLED RELEASE (2022)

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Editorial Material Biotechnology & Applied Microbiology

2021 FDA approvals

Asher Mullard

Summary: The FDA approved 50 novel drugs in 2021, including the first KRAS inhibitor for cancer and the first anti-amyloid antibody for Alzheimer's disease.

NATURE REVIEWS DRUG DISCOVERY (2022)

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Article Cell Biology

Identification of Tumor Antigens and Design of mRNA Vaccine for Colorectal Cancer Based on the Immune Subtype

Cong Liu et al.

Summary: This study identified potential antigens for effective mRNA vaccine design and built an immune landscape for accurate patient selection for mRNA vaccine therapy in CRC. The study also revealed significant cellular and molecular differences among different immune subtypes.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2022)

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Article Public, Environmental & Occupational Health

Prostate Cancer Incidence and Mortality: Global Status and Temporal Trends in 89 Countries From 2000 to 2019

Le Wang et al.

Summary: The study evaluated the current global status of prostate cancer incidence and mortality. The findings indicate that the increase in prostate cancer incidence and the decrease in mortality have slowed down in recent years.

FRONTIERS IN PUBLIC HEALTH (2022)

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Editorial Material Urology & Nephrology

Re: The Genetic Source Tracking of Human Urinary Exosomes

Anthony Atala

JOURNAL OF UROLOGY (2022)

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Review Oncology

Anti-Androgen Receptor Therapies in Prostate Cancer: A Brief Update and Perspective

Jian Huang et al.

Summary: Prostate cancer relies on androgen receptor (AR) and treatments mainly focus on suppressing AR activity or reducing androgen production. Current therapies for castration-resistant prostate cancer (CRPC) have limited effectiveness in part due to AR gene mutations or splicing variations leading to AR reactivation.

FRONTIERS IN ONCOLOGY (2022)

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Article Pharmacology & Pharmacy

Development of an LNP-Encapsulated mRNA-RBD Vaccine against SARS-CoV-2 and Its Variants

Cong Liu et al.

Summary: This study designed an mRNA-based vaccine that can generate broad-spectrum neutralizing antibodies and cellular responses against SARS-CoV-2 and its variants. The results demonstrated that a three-dose regimen of the mRNA-RBD vaccine elicited a strong immune response in mice. This provides important reference for the development of mRNA vaccines targeting SARS-CoV-2 variants.

PHARMACEUTICS (2022)

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Article Pharmacology & Pharmacy

Development and Evaluation of a PSMA-Targeted Nanosystem Co-Packaging Docetaxel and Androgen Receptor siRNA for Castration-Resistant Prostate Cancer Treatment

Yingying Zhang et al.

Summary: In this study, a nanosystem was designed for the treatment of prostate cancer, carrying both docetaxel and androgen receptor siRNA. The results demonstrated that the nanosystem exhibited prolonged blood circulation, selective targeting, and enhanced antitumor effects, holding great potential for efficient treatment of castration-resistant prostate cancer by combining chemotherapy and siRNA silencing of androgen-related signaling pathways.

PHARMACEUTICS (2022)

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Article Biochemistry & Molecular Biology

Definition of Castrate Resistant Prostate Cancer: New Insights

Juan Morote et al.

Summary: Castrate resistant prostate cancer (CRPC) refers to the continued progression of prostate cancer in an environment with very low serum testosterone concentration. The current definition is outdated and needs to be updated with more accurate imaging modalities and biochemical measurements to assess clinical progression and the castration environment.

BIOMEDICINES (2022)

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Review Oncology

Blood-based liquid biopsies for prostate cancer: clinical opportunities and challenges

Blanca Trujillo et al.

Summary: Liquid biopsy is a powerful tool for detecting cancer aberrations in real-time, especially in prostate cancer. However, there are still challenges in screening, risk stratification, and treatment of advanced disease. Therefore, developing better biomarkers is urgently needed to guide oncologists' decisions.

BRITISH JOURNAL OF CANCER (2022)

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Review Oncology

Potential utility of miRNAs for liquid biopsy in breast cancer

Xiangrong Liu et al.

Summary: Breast cancer is the most common malignancy in women, and traditional cancer detection methods are insufficient in detecting the complete cancer genomic landscape, necessitating the development of new strategies. Liquid biopsy has gained attention for its simplicity, early detection, and effective monitoring, with miRNAs potentially playing a crucial role in the diagnosis and prognosis of breast cancer.

FRONTIERS IN ONCOLOGY (2022)

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Review Oncology

Emerging Proteins in CRPC: Functional Roles and Clinical Implications

Piaoping Kong et al.

Summary: This review systematically summarizes the role of emerging proteins in the diagnosis and management of CRPC, including their expression patterns, regulatory mechanisms, and clinical applications.

FRONTIERS IN ONCOLOGY (2022)

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Review Biochemistry & Molecular Biology

Self-Amplifying RNA Approach for Protein Replacement Therapy

Dimitri Papukashvili et al.

Summary: mRNA technology has potential applications in disease prevention and treatment, including infectious and inherited diseases. The saRNA technology shows advantages over conventional mRNA in terms of dosage requirements, side effects, and long-lasting effects. However, there are still challenges to overcome for clinical approval of saRNA-based drugs.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

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Review Oncology

The Crucial Role of AR-V7 in Enzalutamide-Resistance of Castration-Resistant Prostate Cancer

Zeyuan Zheng et al.

Summary: This review summarizes the mechanisms and biological behaviors of AR-V7 in enzalutamide resistance of castration-resistant prostate cancer (CRPC), providing novel insights for CRPC therapy.

CANCERS (2022)

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Article Materials Science, Biomaterials

Peptide-siRNA nanoparticles targeting NF-KB p50 mitigate experimental abdominal aortic aneurysm progression and rupture

Huimin Yan et al.

Summary: In the treatment of abdominal aortic aneurysm (AAA), the different subunits p50 and p65 of the inflammatory signaling pathway NF-KB play different roles in different stages. Selective targeting of p50 may be more effective for the treatment of small AAA.

BIOMATERIALS ADVANCES (2022)

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Review Biochemistry & Molecular Biology

Targeting signaling pathways in prostate cancer: mechanisms and clinical trials

Yundong He et al.

Summary: This review summarizes the targeted agents and their mechanisms for treating prostate cancer (PCa), as well as discusses their limitations and future directions.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2022)

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Review Pharmacology & Pharmacy

The growth of siRNA-based therapeutics: Updated clinical studies

M. May Zhang et al.

Summary: After more than twenty years since the discovery of the natural gene-silencing mechanism of RNA interference, siRNA-based therapeutics have entered the pharmaceutical market with three approved drugs and many others in advanced stages of development. The majority of late-stage candidates are targeted towards rare diseases or patients who have not responded to current treatments, while some have potential for a wider patient population. This review provides an overview of siRNA mechanisms, barriers to delivery, and profiles of approved drugs and candidates in Phase 3 clinical trials.

BIOCHEMICAL PHARMACOLOGY (2021)

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Article Pharmacology & Pharmacy

Lumasiran: First Approval

Lesley J. Scott et al.

Summary: Lumasiran is a drug developed for the treatment of primary hyperoxaluria type 1 by targeting a specific gene to inhibit the synthesis of toxic metabolites. It received approvals in the EU and USA, marking its global recognition.

DRUGS (2021)

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News Item Biotechnology & Applied Microbiology

2020 FDA drug approvals

Asher Mullard

Summary: In 2020, the FDA approved 53 novel drugs, the second highest count in over 20 years.

NATURE REVIEWS DRUG DISCOVERY (2021)

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Article Oncology

Identification of AR-V7 downstream genes commonly targeted by AR/AR-V7 and specifically targeted by AR-V7 in castration resistant prostate cancer

Masahiro Sugiura et al.

Summary: The study found that AR-V7 contributes to the proliferation of CRPC by activating both common AR/AR-V7 target genes and specific AR-V7 target genes, such as NUP210 and SLC3A2. These findings suggest that targeting NUP210 and SLC3A2 may be a potential therapeutic strategy for CRPC.

TRANSLATIONAL ONCOLOGY (2021)

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Article Biochemistry & Molecular Biology

Mesoporous silica nanoparticles combined with AKR1C3 siRNA inhibited the growth of castration-resistant prostate cancer by suppressing androgen synthesis in vitro and in vivo

Junyu Chen et al.

Summary: In this study, mesoporous silica nanoparticles were utilized to deliver small interfering RNA targeting AKR1C3, effectively downregulating intracrine androgen synthesis and inhibiting the development of castration-resistant prostate cancer at both cellular and animal levels.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2021)

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Article Oncology

Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

Hyuna Sung et al.

Summary: The global cancer burden in 2020 saw an estimated 19.3 million new cancer cases and almost 10.0 million cancer deaths. Female breast cancer surpassed lung cancer as the most commonly diagnosed cancer, while lung cancer remained the leading cause of cancer death. These trends are expected to rise in 2040, with transitioning countries experiencing a larger increase compared to transitioned countries due to demographic changes and risk factors associated with globalization and a growing economy. Efforts to improve cancer prevention measures and provision of cancer care in transitioning countries will be crucial for global cancer control.

CA-A CANCER JOURNAL FOR CLINICIANS (2021)

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Article Biochemistry & Molecular Biology

Prostate cancer castrate resistant progression usage of non-canonical androgen receptor signaling and ketone body fuel

Estefania Labanca et al.

Summary: This study revealed the key metabolites driving castration resistant progression in PCa, including significant increases in fatty acids and ketone bodies. Dysregulation of critical ketolytic enzymes (ACAT1, OXCT1, BDH1) was observed after castrate-resistant progression, which was associated with time to biochemical relapse and progression-free survival in PCa patients.

ONCOGENE (2021)

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Review Medicine, Research & Experimental

Advances in siRNA delivery strategies for the treatment of MDR cancer

Md Abdus Subhan et al.

Summary: RNA interference (RNAi) is a promising therapeutic method for cancer treatment using siRNA, but delivery challenges remain. Nano delivery strategies show potential for efficient siRNA delivery to cancer cells.

LIFE SCIENCES (2021)

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Article Biochemistry & Molecular Biology

YAP1 overexpression contributes to the development of enzalutamide resistance by induction of cancer stemness and lipid metabolism in prostate cancer

Hsiu-Chi Lee et al.

Summary: The study identified YAP1 as overexpressed in enzalutamide-resistant cells, with COUP-TFII mediating its induction by enzalutamide. Functional analyses showed that YAP1 positively regulates genes related to cancer stemness and lipid metabolism, and its inhibitor attenuates the growth of EnzaR cells. Furthermore, EnzaR-EVs were found to enhance cancer stemness, lipid metabolism and enzalutamide resistance in parental cells, suggesting YAP1 as a potential therapeutic target for prostate cancer.

ONCOGENE (2021)

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Article Biotechnology & Applied Microbiology

Development of EphA2 siRNA-loaded lipid nanoparticles and combination with a small-molecule histone demethylase inhibitor in prostate cancer cells and tumor spheroids

Ezgi Oner et al.

Summary: Researchers successfully developed novel cationic solid lipid nanoparticles carrying siRNA targeting EphA2 receptor, which showed enhanced gene silencing when co-administered with a histone lysine demethylase inhibitor, JIB-04. The delivery system demonstrated high transfection efficiency and holds promise for targeting other genes and cancer types in further in vitro and in vivo studies.

JOURNAL OF NANOBIOTECHNOLOGY (2021)

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Article Medicine, Research & Experimental

Seed-mediated RNA interference of androgen signaling and survival networks induces cell death in prostate cancer cells

Joshua M. Corbin et al.

Summary: Resistance to anti-androgen therapy in prostate cancer is often driven by genetic and epigenetic aberrations in androgen receptor and coregulatory genes. Specific small RNAs can downregulate essential genes, leading to potent androgen signaling inhibition and cell death. Targeting TMEFF2 with short hairpin/small interfering RNAs may be a novel therapeutic strategy for prostate cancer.

MOLECULAR THERAPY-NUCLEIC ACIDS (2021)

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Review Cell Biology

Perspectives on miRNAs Targeting DKK1 for Developing Hair Regeneration Therapy

Dimitri Papukashvili et al.

Summary: Androgenetic alopecia (AGA) is a challenging issue that requires the development of new treatment methods. The Wnt/β-catenin signaling pathway is crucial for hair growth and can be targeted for AGA therapy.

CELLS (2021)

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Article Medicine, General & Internal

Impact and effectiveness of mRNA BNT162b2 vaccine against SARS-CoV-2 infections and COVID-19 cases, hospitalisations, and deaths following a nationwide vaccination campaign in Israel: an observational study using national surveillance data

Eric J. Haas et al.

Summary: This study assessed the real-world effectiveness of the Pfizer-BioNTech mRNA COVID-19 vaccine BNT162b2 in Israel, showing high efficacy in preventing SARS-CoV-2 infections, hospitalizations, severe disease, and death. As vaccine coverage increased, there were marked declines in SARS-CoV-2 outcomes, indicating that COVID-19 vaccination can help control the pandemic.

LANCET (2021)

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Review Urology & Nephrology

Treatment and trials in non-metastatic castration-resistant prostate cancer

Soum D. Lokeshwar et al.

Summary: Metastatic prostate cancer is associated with high morbidity and mortality rates. Treatment of non-metastatic prostate cancer often involves androgen deprivation therapy (ADT), but many patients eventually develop castration-resistant prostate cancer (CRPC). A new stage called non-metastatic CRPC (nmCRPC) has gained attention, with three novel nonsteroidal antiandrogens (enzalutamide, apalutamide, darolutamide) showing promising results in clinical trials.

NATURE REVIEWS UROLOGY (2021)

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Article Medicine, Research & Experimental

Improved cardiac-specific delivery of RAGE siRNA within small extracellular vesicles engineered to express intense cardiac targeting peptide attenuates myocarditis

Hyoeun Kim et al.

Summary: This study evaluated the use of modified sEVs expressing high levels of cardiac-targeting peptide for therapeutic siRNA delivery in myocarditis. The results showed that the efficiency of cardiac-specific siRNA delivery via these modified sEVs was higher than that of normal sEVs, and they attenuated inflammation in both cell culture and an in vivo model of myocarditis. The findings suggest that these modified sEVs may serve as a useful drug delivery vehicle for the treatment of heart disease.

MOLECULAR THERAPY-NUCLEIC ACIDS (2021)

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Article Biochemistry & Molecular Biology

Synthesis of KUE-siRNA Conjugates for Prostate Cancer Cell-Targeted Gene Silencing

Chao Yang et al.

Summary: This study successfully synthesized KUE-siRNA conjugates targeting PSMA, which were able to selectively enter and down-regulate STAT3 expression in prostate cancer cells, providing a potential new method for cell-targeted gene silencing.

CHEMBIOCHEM (2021)

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Article Pharmacology & Pharmacy

siRNA: Mechanism of action, challenges, and therapeutic approaches

Walhan Alshaer et al.

Summary: siRNA functions in gene silencing and targets disease-related genes, yet it faces issues such as low cellular uptake and susceptibility to degradation, requiring a carrier for protection and delivery.

EUROPEAN JOURNAL OF PHARMACOLOGY (2021)

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Review Biochemistry & Molecular Biology

AR-V7 in Metastatic Prostate Cancer: A Strategy beyond Redemption

Navid Sobhani et al.

Summary: Metastatic prostate cancer is the most common cancer in males with a poor prognosis, and many patients develop the AR-V7 variant. AR-V7 acts as a transcription factor in the nucleus, repressing crucial tumor suppressor genes. Anti-AR-V7 drugs show promise for this subset of patients.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Review Biotechnology & Applied Microbiology

mRNA vaccines for infectious diseases: principles, delivery and clinical translation

Namit Chaudhary et al.

Summary: mRNA vaccines have been established as a rapid, effective, and safe approach for protecting individuals from infectious diseases, especially during the COVID-19 pandemic. Further research is needed to optimize mRNA vaccine design, delivery, and applications for a range of infectious diseases.

NATURE REVIEWS DRUG DISCOVERY (2021)

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Review Oncology

Clinicopathological characteristics of androgen receptor splicing variant 7 (AR-V7) expression in patients with castration resistant prostate cancer: A systematic review and meta-analysis

Qinchen Li et al.

Summary: Studies suggest that AR-V7 positivity in CRPC patients is associated with higher Gleason scores, bone or any site metastasis, increased pain incidence, and worse ECOG performance status. However, it is not correlated with tumor stage or lymph node metastasis. Further research is needed to validate these findings.

TRANSLATIONAL ONCOLOGY (2021)

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Article Pharmacology & Pharmacy

Suppression of FGF5 and FGF18 Expression by Cholesterol-Modified siRNAs Promotes Hair Growth in Mice

Jungang Zhao et al.

Summary: The study demonstrates that by inhibiting the genes FGF5 and FGF18, the hair follicle cycle can be effectively regulated to prolong the anagen phase or promote hair follicles to enter the anagen phase. Cholesterol-modified siRNA shows better expression inhibition effects both in vitro and in vivo. Intradermal injection of cholesterol-modified siRNA can effectively intervene in the hair follicle cycle, while topical application of cream also has similar inhibitory effects.

FRONTIERS IN PHARMACOLOGY (2021)

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Review Oncology

AR Splicing Variants and Resistance to AR Targeting Agents

Mayuko Kanayama et al.

Summary: Androgen receptor splice variants (AR-Vs) play a crucial role in prostate cancer progression, particularly as a resistance mechanism against AR-targeted therapies. Advances in prostate cancer research have led to the discovery of novel biomarkers and effective treatments, emphasizing the importance of further developing and utilizing optimal biomarkers for treatment optimization.

CANCERS (2021)

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Article Oncology

Molecular Phenotyping of AR Signaling for Predicting Targeted Therapy in Castration Resistant Prostate Cancer

Agus Rizal A. H. Hamid et al.

Summary: Castration-resistant prostate cancer (CRPC) is characterized by tumor resistance to androgen deprivation therapy (ADT), with molecular changes in the AR signaling cascade explaining ADT resistance. Testing for specific molecular changes in the AR signaling pathway before treatment may lead to personalized treatment. A study evaluated molecular changes in CRPC patients and found that the majority still had an active AR signaling pathway, with heterogeneity in observed molecular changes classified into 4 major subgroups. Fresh tissue samples before starting new treatment are recommended for characterizing the AR signaling pathway in CRPC patients.

FRONTIERS IN ONCOLOGY (2021)

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Review Pharmacology & Pharmacy

Clinical Advances of siRNA-Based Nanotherapeutics for Cancer Treatment

Dima Hattab et al.

Summary: RNA interference (RNAi) offers a genetic approach for cancer treatment by inhibiting specific messenger RNA signaling uncontrollable cell growth and proliferation. Challenges such as low tumor localization, stability and rapid clearance from circulation hinder the success of gene therapy applications.

PHARMACEUTICS (2021)

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Review Cell Biology

The Emerging Mechanisms of Wnt Secretion and Signaling in Development

Shefali Mehta et al.

Summary: Wnt proteins are lipid-modified secreted proteins that activate multiple signaling pathways, regulating crucial processes during development. Despite being hydrophobic, they can travel several cell distances in the extracellular space. Research has identified factors and mechanisms regulating their expression, secretion, and extracellular travel, recognizing the importance of Wnt protein gradients in maintaining tissue homeostasis.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2021)

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Review Urology & Nephrology

Recent Global Patterns in Prostate Cancer Incidence and Mortality Rates

MaryBeth B. Culp et al.

EUROPEAN UROLOGY (2020)

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Article Biochemistry & Molecular Biology

The role of actinin-4 (ACTN4) in exosomes as a potential novel therapeutic target in castration-resistant prostate cancer

Yu Ishizuya et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2020)

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Article Pharmacology & Pharmacy

Givosiran: First Approval

Lesley J. Scott

DRUGS (2020)

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Article Oncology

Baldness and Risk of Prostate Cancer in the Health Professionals Follow-up Study

Saud Khan et al.

CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION (2020)

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Article Multidisciplinary Sciences

2,4-dienoyl-CoA reductase regulates lipid homeostasis in treatment-resistant prostate cancer

Arnaud Blomme et al.

NATURE COMMUNICATIONS (2020)

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Article Urology & Nephrology

Analysis of AR-FL and AR-V1 in Whole Blood of Patients with Castration Resistant Prostate Cancer as a Tool for Predicting Response to Abiraterone Acetate

Kristina Stuopelyte et al.

JOURNAL OF UROLOGY (2020)

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Article Medicine, General & Internal

Two Phase 3 Trials of Inclisiran in Patients with Elevated LDL Cholesterol

Kausik K. Ray et al.

NEW ENGLAND JOURNAL OF MEDICINE (2020)

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Article Biochemistry & Molecular Biology

Generation and validation of structurally defined antibody-siRNA conjugates

Alex R. Nanna et al.

NUCLEIC ACIDS RESEARCH (2020)

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Article Oncology

Aspartate β-hydroxylase targeting in castration-resistant prostate cancer modulates the NOTCH/HIF1α/GSK3β crosstalk

Paola Barboro et al.

CARCINOGENESIS (2020)

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Review Biochemistry & Molecular Biology

The PI3K-AKT-mTOR Pathway and Prostate Cancer: At the Crossroads of AR, MAPK, and WNT Signaling

Boris Y. Shorning et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

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Article Oncology

Efficacy and Safety of Androgen-Deprivation Therapy Combined with Docetaxel Plus Prednisone in High-Burden Metastatic Hormone-Sensitive Prostate Cancer

Linjun Hu et al.

CANCER MANAGEMENT AND RESEARCH (2020)

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Article Health Care Sciences & Services

Protein Expression Analysis of an In Vitro Murine Model of Prostate Cancer Progression: Towards Identification of High-Potential Therapeutic Targets

Hisham F. Bahmad et al.

JOURNAL OF PERSONALIZED MEDICINE (2020)

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Article Medicine, General & Internal

Evaluation of the mRNA-1273 Vaccine against SARS-CoV-2 in Nonhuman Primates

Kizzmekia S. Corbett et al.

NEW ENGLAND JOURNAL OF MEDICINE (2020)

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Article Medicine, General & Internal

Safety and Immunogenicity of Two RNA-Based Covid-19 Vaccine Candidates

Edward E. Walsh et al.

NEW ENGLAND JOURNAL OF MEDICINE (2020)

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Review Oncology

Targeting the Wnt/β-catenin signaling pathway in cancer

Ya Zhang et al.

JOURNAL OF HEMATOLOGY & ONCOLOGY (2020)

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Article Cell Biology

α-Actinin-4 Promotes the Progression of Prostate Cancer Through the Akt/GSK-3β/β-Catenin Signaling Pathway

Sungyeon Park et al.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2020)

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Review Oncology

Development and prevalence of castration-resistant prostate cancer subtypes

Jordan E. Vellky et al.

NEOPLASIA (2020)

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Review Biotechnology & Applied Microbiology

Progress in Delivery of siRNA-Based Therapeutics Employing Nano-Vehicles for Treatment of Prostate Cancer

Milad Ashrafizadeh et al.

BIOENGINEERING-BASEL (2020)

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Article Urology & Nephrology

Hypofractionated Radiation Therapy for Localized Prostate Cancer: Executive Summary of an ASTRO, ASCO and AUA Evidence-Based Guideline

Scott C. Morgan et al.

JOURNAL OF UROLOGY (2019)

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Article Oncology

Comparative Analysis of AR Variant AR-V567es mRNA Detection Systems Reveals Eminent Variability and Questions the Role as a Clinical Biomarker in Prostate Cancer

Christof Bernemann et al.

CLINICAL CANCER RESEARCH (2019)

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Review Nanoscience & Nanotechnology

Small interfering RNAs (siRNAs) in cancer therapy: a nano-based approach

Ghanbar Mahmoodi Chalbatani et al.

INTERNATIONAL JOURNAL OF NANOMEDICINE (2019)

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Article Chemistry, Medicinal

Codelivery of GRP78 siRNA and docetaxel via RGD-PEG-DSPE/DOPA/CaP nanoparticles for the treatment of castration-resistant prostate cancer

Xiangyu Zhang et al.

DRUG DESIGN DEVELOPMENT AND THERAPY (2019)

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Article Multidisciplinary Sciences

Selective targeting of PARP-2 inhibits androgen receptor signaling and prostate cancer growth through disruption of FOXA1 function

Bin Gui et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2019)

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Article Biochemistry & Molecular Biology

p66Shc protein through a redox mechanism enhances the progression of prostate cancer cells towards castration-resistance

Dannah R. Miller et al.

FREE RADICAL BIOLOGY AND MEDICINE (2019)

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Review Andrology

Role of Androgen Receptor in Prostate Cancer: A Review

Kazutoshi Fujita et al.

WORLD JOURNAL OF MENS HEALTH (2019)

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Small-interfering RNA-induced androgen receptor silencing leads to apoptotic cell death in prostate cancer

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siRNA-based approaches for castration-resistant prostate cancer therapy targeting the androgen receptor signaling pathway

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