期刊
FUTURE MICROBIOLOGY
卷 -, 期 -, 页码 -出版社
FUTURE MEDICINE LTD
DOI: 10.2217/fmb-2023-0107
关键词
central nervous system; cerebrospinal fluid; encephalitis; metagenomic next-generation sequencing; Varicella Zoster virus
类别
We report a rare case of acute varicella zoster viral encephalitis in an immunocompetent adult patient without cutaneous herpes, diagnosed through metagenomic next-generation sequencing of cerebrospinal fluid.
Acute Varicella Zoster viral encephalitis in immunocompetent adult patients without cutaneous herpes has rarely been reported. A 24-year-old female was hospitalized for a headache with a fever but without other obvious symptoms. Multiple routine examinations showed no abnormalities. Lumbar puncture indicated intracranial hypertension. The examination of cerebrospinal fluid by metagenomic next-generation sequencing demonstrated acute Varicella Zoster viral encephalitis. The patient's condition improved by treatment with acyclovir for antiviral therapy and mannitol dehydration to lower cranial pressure. Central Varicella Zoster viral infection should be emphasized as it is easily misdiagnosed and rare in clinical settings. Metagenomic next-generation sequencing of cerebrospinal fluid has significant advantages in the diagnosis of Varicella Zoster viral encephalitis.
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