4.7 Article

SERPINE1 and SERPINB7 as potential biomarkers for intravenous vitamin C treatment in non-small-cell lung cancer

期刊

FREE RADICAL BIOLOGY AND MEDICINE
卷 209, 期 -, 页码 96-107

出版社

ELSEVIER SCIENCE INC
DOI: 10.1016/j.freeradbiomed.2023.10.391

关键词

Intravenous vitamin C; Non-small cell lung cancer (NSCLC); Biomarker; SERPINE1; SERPINB7

向作者/读者索取更多资源

This study explored the effect of high-dose intravenous vitamin C (IVC) treatment on gene expression in non-small cell lung cancer (NSCLC) cells and identified SERPINE1 and SERPINB7 as downregulated genes following IVC treatment. These genes were found to be related to patient prognosis in NSCLC, with high expression correlated with favorable prognosis in patients receiving IVC treatment.
High dose intravenous vitamin C (IVC) has been proposed as a pro-oxidant anticancer agent. However, there is a lack of biomarkers that are specific for this treatment. Here, we explored profiles of gene expression responding to IVC treatment in non-small cell lung cancer (NSCLC) cells as an effort for potential biomarker discovery. Genome-wide RNA-seq was performed in human NSCLC cell lines treated with pharmacological concentrations of vitamin C(VitC) for differential expression of genes. The identified genes were analyzed for correlations with patient prognosis using data from the Kaplan-Meier Plotter and the Human Protein Atlas databases. Further, tumor samples from a retrospective study of 153 NSCLC patients were analyzed with immunohistochemistry for expression of targeted genes, and patient prognosis was correlated to these genes. Two genes, namely SERPINE1 and SERPINB7 were found to be downregulated in NSCLC cells following VitC treatment. Combined patient data from the cohort analysis and online databases revealed that these 2 genes presented an unfavorable prognostic prediction of overall survival (OS) in NSCLC patients receiving standard of care. However, high expression level of these 2 genes were associated with prolonged OS in NSCLC patients receiving IVC in addition to standard of care. These data revealed that SERPINE1 and SERPINB7 have the potential to serve as predictive factors indicating favorable responses to IVC treatment in patients with NSCLC. Further validations are warranted.

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.7
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

暂无数据
暂无数据