期刊
FOOD SCIENCE AND BIOTECHNOLOGY
卷 -, 期 -, 页码 -出版社
KOREAN SOCIETY FOOD SCIENCE & TECHNOLOGY-KOSFOST
DOI: 10.1007/s10068-023-01376-0
关键词
Melanogenesis; MITF; Spergularia marina; Tyrosinase
In this study, the skin-whitening effects of S. marina extract (SME) were investigated. SME exhibited radical-scavenging and anti-inflammatory effects, and inhibited α-melanocyte-stimulating hormone-induced melanogenesis and tyrosinase activity. The inhibitory mechanism involved downregulation of TRP-1, TRP-2, and tyrosinase protein expression, as well as the inhibition of MITF nuclear translocation.
Spergularia marina is a plant that grows in salty regions along the coastline and exerts radical-scavenging and anti-inflammatory effects. In this study, we investigated the skin-whitening effects of S. marina extract (SME) in B16F10 melanoma cells. SME was found to exert radical-scavenging effects. It suppressed & alpha;-melanocyte-stimulating hormone-induced melanogenesis and tyrosinase activity. We also assessed the melanin production signaling pathway to identify the inhibitory action mechanism of SME on melanogenesis. SME decreased the protein expression levels of tyrosinase-related protein (TRP)-1, TRP-2, and tyrosinase, which play important roles in melanogenesis. Furthermore, western blotting revealed that SME inhibited the nuclear translocation of melanocyte inducing transcription factor (MITF), which is a transcription factor for TRP-1, TRP-2, and tyrosinase, suggesting that SME exerts its skin-whitening effect by inhibiting MITF nuclear translocation. Therefore, SME may potentially be used in skin-whitening medicines and cosmetics.
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