Regulation of gut microbiota by vitamin C, vitamin E and β-carotene

Vitamin C (VC), vitamin E (VE) and beta-carotene (beta C) are representative dietary antioxidants, which exist in daily diet and can increase the antioxidant capacity of body fluids, cells and tissues. The health benefits of vitamins like VC, VE and beta C are widely demonstrated. Given that the strong associations between the gut microbiota and host health or a range of diseases has been extensively reported, it is important to explore the modulatory effects of known vitamins on the gut microbiota. Herein, this article reviews the effects of VC, VE and beta C on the gut microbiota. Totally, 19 studies were included, of which eight were related to VC, nine to VE, and six to beta C. Overall, VC, VE and beta C can provide health benefits to the host by modulating the composition and metabolic activity of the gut microbiota, improving intestinal barrier function and maintaining the normal function of the immune system. Two perspectives are proposed for future studies: i) roles of known antioxidant activity of vitamins in regulating the gut microbiota and its molecular mechanism need to be further studied; ii) causal relationships between the regulatory effects of vitamins on gut microbiota and host health still remains to be further verified.

Automated summary

Vitamin C (VC), vitamin E (VE), and beta-carotene (beta C) are dietary antioxidants that can enhance the body's antioxidant capacity. Their effects on the gut microbiota were reviewed in this article, with 19 studies included. VC, VE, and beta C can modulate the composition and activity of the gut microbiota, improve intestinal barrier function, and support the normal function of the immune system, providing health benefits to the host. Future studies should further investigate the antioxidant activity of vitamins on the gut microbiota and explore the causal relationships between vitamin regulation of the gut microbiota and host health.