期刊
FOOD CHEMISTRY
卷 418, 期 -, 页码 -出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.foodchem.2023.135998
关键词
Surface -enhanced Raman scattering; Chloramphenicol; Flexible PDMS; AuNTs; Chemometric algorithms
The misuse of chloramphenicol (CAP) has led to drug-resistant strains, posing a significant threat to public health. A flexible surface-enhanced Raman spectroscopy (SERS) sensor using gold nanotriangles (AuNTs) and polydimethylsiloxane (PDMS) film was proposed for rapid detection of CAP in food samples. The sensor showed promising results with high accuracy and compatibility with conventional methods, suggesting its potential for monitoring milk quality and safety.
The misuse of chloramphenicol (CAP) has led to the development of drug-resistant strains that pose significant threats to public health. Here, we propose a universal flexible surface-enhanced Raman spectroscopy (SERS) sensor utilizing gold nanotriangles (AuNTs) and polydimethylsiloxane (PDMS) film for rapid detection of CAP in food samples. Initially, AuNTs@PDMS with unique optical and plasmonic properties were used to collect spectra of CAP. Afterward, four chemometric algorithms were executed and compared. Accordingly, random frog-partial least squares (RF-PLS) exhibited optimum results with correlation coefficient of prediction (Rp = 0.9802) and the lowest root-mean-square error of prediction (RMSEP = 0.348 mu g/mL). Furthermore, the sensor's efficacy to detect CAP in milk samples was confirmed, and the findings were compatible with the conventional HPLC approach (P > 0.05). Therefore, the proposed flexible SERS sensor could effectively be used to monitor milk quality and safety.
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