期刊
FOOD CHEMISTRY
卷 421, 期 -, 页码 -出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.foodchem.2023.136152
关键词
Raspberry; Polysaccharide; Colon; Inflammation; Gut microbiota
In this study, a novel polysaccharide derived from unripe raspberry fruits (pRCP) was extracted and characterized. pRCP showed high homogeneity and consisted of an acidic heteropolysaccharide with a molecular weight of 74.86 kDa. Supplementation with pRCP improved gut microbial diversity and reduced harmful bacteria in high-fat diet-fed mice, while also alleviating colonic inflammation and oxidative stress. These beneficial effects were transferable through fecal microbiota transplantation from pRCP-treated mice, indicating the potential of pRCP as a prebiotic for improving intestinal health.
Raspberry is used as a medicine food homology species and its polysaccharides are worthy being investigated and developed. In the present study, a novel polysaccharide of unripe raspberry fruits (pRCP) was extracted and characterized. The results show that pRCP was an acidic heteropolysaccharide and its Mw value was 74.86 kDa with a high homogeneity. The main chain of pRCP consisted of -> 3,6)-beta-Galp(1 -> and -> 5)-alpha-Araf(1 ->, and its side chain was composed of alpha-Araf(1 -> linked to the C3 position of -> 3,6)-beta-Galp(1 ->. In addition, pRCP supplementation increased the gut microbial diversity and reduced harmful bacteria including Erysipelatoclostridium and Negativibacillus in high-fat diet (HFD)-fed mice. Treatment with pRCP also alleviated HFD-induced colonic inflammation and oxidative stress in mice. These beneficial effects can be transferred to recipient mice by faecal microbiota transplantation from pRCP-treated mice. Therefore, our study suggests that pRCP could be used as a potential prebiotics to improve intestinal health by modulating the gut microbiota.
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